SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kw7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_A_T44A428_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		4 / 4 LYS A 187
LEU A 183
ALA A 241
LEU A 237
 None
 1.46A 1f86A-4kw7A:
undetectable		 1f86A-4kw7A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		4 / 4 LYS A 187
LEU A 183
ALA A 241
LEU A 237
 None
 1.24A 1f86B-4kw7A:
undetectable		 1f86B-4kw7A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		4 / 8 SER A 166
VAL A 192
VAL A 162
LEU A 193
 None
 1.04A 2ddwA-4kw7A:
undetectable		 2ddwA-4kw7A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		4 / 5 VAL A 128
SER A 102
VAL A  98
SER A 142
 None
 1.36A 2j9cA-4kw7A:
undetectable
2j9cB-4kw7A:
undetectable
2j9cC-4kw7A:
undetectable		 2j9cA-4kw7A:
18.23
2j9cB-4kw7A:
18.23
2j9cC-4kw7A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		5 / 12 GLY A  95
GLY A  93
GLY A  71
ASP A  97
VAL A  98
 None
 1.01A 2oxtC-4kw7A:
6.6		 2oxtC-4kw7A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		3 / 3 GLU A 160
SER A 166
VAL A 167
 None
 0.78A 3eeoA-4kw7A:
7.3		 3eeoA-4kw7A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		4 / 8 GLY A 252
CYH A 224
PHE A 186
PHE A 201
 None
PA0  A 403 (-2.2A)
None
None
 1.04A 3ko0D-4kw7A:
undetectable
3ko0E-4kw7A:
undetectable		 3ko0D-4kw7A:
15.30
3ko0E-4kw7A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		5 / 10 LEU A 154
GLY A 113
ILE A 171
VAL A 192
VAL A 162
 None
 1.05A 3nu9B-4kw7A:
undetectable		 3nu9B-4kw7A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		4 / 6 PHE A 135
PHE A 136
ASN A 143
ALA A 101
 None
 1.18A 3t3sB-4kw7A:
undetectable		 3t3sB-4kw7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		3 / 3 ASP A  97
ARG A  96
ASP A 115
 None
 0.81A 4fp9A-4kw7A:
8.7		 4fp9A-4kw7A:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		9 / 12 GLY A  91
ASP A  97
MET A 116
LEU A 117
PHE A 150
ILE A 151
GLU A 152
VAL A 175
LEU A 178
 CA  A 401 (-4.4A)
None
None
None
None
None
None
None
None
 1.04A 4fr0A-4kw7A:
46.9		 4fr0A-4kw7A:
98.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		8 / 12 GLY A  91
GLY A  93
ASP A  97
MET A 116
LEU A 117
GLN A 120
ILE A 151
GLU A 152
 CA  A 401 (-4.4A)
None
None
None
None
None
None
None
 0.75A 4fr0A-4kw7A:
46.9		 4fr0A-4kw7A:
98.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		8 / 12 GLY A  91
GLY A  93
ASP A  97
MET A 116
LEU A 117
PHE A 150
ILE A 151
GLU A 152
 CA  A 401 (-4.4A)
None
None
None
None
None
None
None
 0.73A 4fr0A-4kw7A:
46.9		 4fr0A-4kw7A:
98.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		7 / 12 GLY A  91
MET A 116
LEU A 117
GLN A 120
ILE A 151
GLU A 152
ASN A 173
 CA  A 401 (-4.4A)
None
None
None
None
None
None
 0.82A 4fr0A-4kw7A:
46.9		 4fr0A-4kw7A:
98.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		9 / 12 GLY A  91
MET A 116
LEU A 117
PHE A 150
ILE A 151
GLU A 152
ASN A 173
VAL A 175
LEU A 178
 CA  A 401 (-4.4A)
None
None
None
None
None
None
None
None
 0.92A 4fr0A-4kw7A:
46.9		 4fr0A-4kw7A:
98.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		5 / 11 SER A  53
ALA A  78
LEU A  82
ILE A 189
LEU A 185
 None
 1.12A 4kt0A-4kw7A:
undetectable
4kt0J-4kw7A:
undetectable		 4kt0A-4kw7A:
19.45
4kt0J-4kw7A:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		5 / 11 LEU A 100
SER A  53
ASP A  79
LEU A  76
LEU A  58
 None
 1.28A 4or0A-4kw7A:
undetectable		 4or0A-4kw7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		4 / 5 SER A 331
GLY A 196
ARG A 332
GLU A 198
 None
 1.21A 4r82A-4kw7A:
undetectable
4r82B-4kw7A:
undetectable		 4r82A-4kw7A:
20.27
4r82B-4kw7A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		4 / 5 GLY A 298
ARG A 314
GLY A 301
GLU A 302
 None
 1.26A 4z2eB-4kw7A:
undetectable
4z2eC-4kw7A:
undetectable		 4z2eB-4kw7A:
22.58
4z2eC-4kw7A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		4 / 6 SER A 272
ASP A  97
ARG A  96
GLY A  71
 None
 0.88A 5cdnA-4kw7A:
undetectable
5cdnB-4kw7A:
undetectable		 5cdnA-4kw7A:
21.74
5cdnB-4kw7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		5 / 10 SER A  53
ALA A  78
LEU A  82
ILE A 189
LEU A 185
 None
 1.22A 5oy01-4kw7A:
undetectable
5oy07-4kw7A:
undetectable		 5oy01-4kw7A:
12.25
5oy07-4kw7A:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		4 / 6 ARG A 308
ARG A 276
PHE A 304
ILE A 328
 None
 1.06A 5vceA-4kw7A:
undetectable		 5vceA-4kw7A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		4 / 6 ARG A 308
PHE A 310
PHE A 304
ILE A 327
 None
 1.15A 5vceA-4kw7A:
undetectable		 5vceA-4kw7A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 4kw7 ARSENIC
METHYLTRANSFERASE
(Cyanidioschyzon
sp.
5508) 		5 / 12 LYS A 110
VAL A 105
SER A  74
VAL A 170
ILE A 169
 None
None
CA  A 401 ( 4.3A)
None
None
 1.35A 6gsdA-4kw7A:
4.9		 6gsdA-4kw7A:
13.25