SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kwb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA
(Bacillus
subtilis) 		3 / 3 PHE A  89
LEU A 107
MET A 141
 None
 0.88A 1mx1D-4kwbA:
undetectable		 1mx1D-4kwbA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA
(Bacillus
subtilis) 		5 / 12 TYR A  84
HIS A  86
LEU A 107
ILE A  69
SER A 147
 None
 1.45A 1xlxA-4kwbA:
undetectable		 1xlxA-4kwbA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA
(Bacillus
subtilis) 		5 / 12 TYR A  84
HIS A  86
LEU A 107
ILE A  69
SER A 147
 None
 1.46A 1xmuB-4kwbA:
undetectable		 1xmuB-4kwbA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA
(Bacillus
subtilis) 		3 / 3 SER A 205
GLU A 191
ASP A 200
 None
 0.84A 3bwmA-4kwbA:
undetectable		 3bwmA-4kwbA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA
(Bacillus
subtilis) 		3 / 3 SER A 205
GLU A 191
ASP A 200
 None
 0.85A 3bwyA-4kwbA:
undetectable		 3bwyA-4kwbA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA
(Bacillus
subtilis) 		5 / 12 MET A 237
ILE A 231
ILE A 245
ALA A 246
ILE A 159
 None
 0.97A 3vrmA-4kwbA:
undetectable		 3vrmA-4kwbA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA
(Bacillus
subtilis) 		5 / 9 SER A 111
GLY A 113
SER A 119
GLY A 114
THR A  68
 None
 1.44A 4lb0A-4kwbA:
undetectable		 4lb0A-4kwbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA
(Bacillus
subtilis) 		3 / 3 SER A 205
GLU A 191
ASP A 200
 None
 0.84A 4xudA-4kwbA:
undetectable		 4xudA-4kwbA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA
(Bacillus
subtilis) 		4 / 5 LEU A 259
TYR A 251
ALA A 246
ILE A 231
 None
 1.05A 4y03B-4kwbA:
undetectable		 4y03B-4kwbA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA
(Bacillus
subtilis) 		5 / 12 MET A 275
TYR A 138
ILE A 129
ALA A  61
TYR A 290
 None
 1.14A 5kvaA-4kwbA:
undetectable		 5kvaA-4kwbA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA
(Bacillus
subtilis) 		5 / 12 MET A 275
TYR A 138
ILE A 129
ALA A  61
TYR A 290
 None
 1.18A 5kvaB-4kwbA:
undetectable		 5kvaB-4kwbA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA
(Bacillus
subtilis) 		3 / 3 GLY A 168
VAL A 109
MET A 141
 None
 0.66A 5ycpA-4kwbA:
undetectable		 5ycpA-4kwbA:
18.32