SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 TYR A 122
GLU A 239
ASP A 240
GLU A 265
ASP A 319
 None
MG  A 501 (-2.8A)
MG  A 501 ( 4.7A)
MG  A 501 ( 2.5A)
GOL  A 502 (-2.8A)
 1.48A 1dy4A-4kwsA:
undetectable		 1dy4A-4kwsA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 GLY A  34
ALA A  90
GLY A 294
ILE A 295
THR A  68
 None
 0.96A 1k6cB-4kwsA:
undetectable		 1k6cB-4kwsA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 4 HIS A 330
ALA A 367
PHE A 365
GLY A 326
 None
 1.23A 1mj2B-4kwsA:
undetectable		 1mj2B-4kwsA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 4 HIS A 330
ALA A 367
PHE A 365
GLY A 326
 None
 1.16A 1mj2D-4kwsA:
undetectable		 1mj2D-4kwsA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 4 HIS A 330
ALA A 367
PHE A 365
GLY A 326
 None
 1.21A 1mjoB-4kwsA:
undetectable		 1mjoB-4kwsA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 4 HIS A 330
ALA A 367
PHE A 365
GLY A 326
 None
 1.27A 1mjoA-4kwsA:
undetectable		 1mjoA-4kwsA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 5 ARG A 149
ASP A 319
ASN A  18
TYR A 161
 None
GOL  A 502 (-2.8A)
None
None
 1.21A 1nbiB-4kwsA:
0.8		 1nbiB-4kwsA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 TRP A 405
VAL A 394
PRO A 393
 None
 0.80A 1rg1A-4kwsA:
undetectable		 1rg1A-4kwsA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 TRP A 405
VAL A 394
PRO A 393
 None
 0.79A 1rh0A-4kwsA:
undetectable		 1rh0A-4kwsA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 10 GLY A  34
ALA A  90
GLY A 294
ILE A 295
THR A  68
 None
 0.98A 1t7iA-4kwsA:
undetectable		 1t7iA-4kwsA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 GLN A 278
ILE A 277
TYR A 308
 None
 0.71A 1vifA-4kwsA:
undetectable		 1vifA-4kwsA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 THR A  84
PRO A  82
THR A  86
 CL  A 503 ( 4.8A)
CL  A 503 (-3.9A)
None
 0.74A 209dC-4kwsA:
undetectable		 209dC-4kwsA:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 GLY A  34
ILE A  88
GLY A 293
GLY A 294
ILE A 295
 None
 0.81A 2avvA-4kwsA:
undetectable		 2avvA-4kwsA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 11 GLY A  34
ILE A  88
GLY A 294
ILE A 295
THR A  68
 None
 0.86A 2nnpA-4kwsA:
undetectable		 2nnpA-4kwsA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 VAL A 394
TRP A 184
TRP A 403
 None
 1.22A 2xdcA-4kwsA:
undetectable
2xdcB-4kwsA:
undetectable		 2xdcA-4kwsA:
3.41
2xdcB-4kwsA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 TRP A 403
VAL A 394
TRP A 184
 None
 1.21A 2xdcA-4kwsA:
undetectable
2xdcB-4kwsA:
undetectable		 2xdcA-4kwsA:
3.41
2xdcB-4kwsA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 VAL A 394
TRP A 184
TRP A 403
 None
 1.36A 2xdcC-4kwsA:
undetectable
2xdcD-4kwsA:
undetectable		 2xdcC-4kwsA:
3.41
2xdcD-4kwsA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 VAL A 394
TRP A 184
TRP A 403
 None
 1.23A 2y5mA-4kwsA:
undetectable
2y5mB-4kwsA:
undetectable		 2y5mA-4kwsA:
3.41
2y5mB-4kwsA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 VAL A 394
TRP A 184
TRP A 403
 None
 1.22A 2y6nA-4kwsA:
undetectable
2y6nB-4kwsA:
undetectable		 2y6nA-4kwsA:
3.41
2y6nB-4kwsA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 TRP A 403
VAL A 394
TRP A 184
 None
 1.20A 2y6nA-4kwsA:
undetectable
2y6nB-4kwsA:
undetectable		 2y6nA-4kwsA:
3.41
2y6nB-4kwsA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 GLY A  34
ILE A  88
GLY A 294
ILE A 295
THR A  68
 None
 0.81A 3d1xA-4kwsA:
undetectable		 3d1xA-4kwsA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 GLY A  34
ILE A  88
GLY A 294
ILE A 295
THR A  68
 None
 0.82A 3d1yA-4kwsA:
undetectable		 3d1yA-4kwsA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 GLY A  34
ILE A  88
GLY A 294
ILE A 295
THR A  68
 None
 0.87A 3el4A-4kwsA:
undetectable		 3el4A-4kwsA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 GLY A  34
ALA A  90
GLY A 294
ILE A 295
THR A  68
 None
 0.89A 3el5B-4kwsA:
undetectable		 3el5B-4kwsA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 10 GLY A  34
ALA A  90
GLY A 294
ILE A 295
THR A  68
 None
 0.92A 3el9B-4kwsA:
undetectable		 3el9B-4kwsA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 PRO A 336
PHE A 331
ALA A 302
 None
 0.71A 3itaD-4kwsA:
undetectable		 3itaD-4kwsA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 ASP A  97
LEU A 289
PHE A 331
ILE A 295
ASP A 357
 None
 1.24A 3ko0G-4kwsA:
undetectable
3ko0H-4kwsA:
undetectable
3ko0I-4kwsA:
undetectable
3ko0J-4kwsA:
undetectable		 3ko0G-4kwsA:
13.82
3ko0H-4kwsA:
13.82
3ko0I-4kwsA:
13.82
3ko0J-4kwsA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 ASP A 357
LEU A 289
PHE A 331
ILE A 295
ASP A  97
 None
 1.18A 3ko0G-4kwsA:
undetectable
3ko0H-4kwsA:
undetectable
3ko0I-4kwsA:
undetectable
3ko0J-4kwsA:
undetectable		 3ko0G-4kwsA:
13.82
3ko0H-4kwsA:
13.82
3ko0I-4kwsA:
13.82
3ko0J-4kwsA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 GLY A  34
ALA A  94
ASP A  97
ILE A  98
ILE A  11
 None
 1.04A 3ogqB-4kwsA:
undetectable		 3ogqB-4kwsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 ALA A  36
GLY A  34
MET A  93
PHE A  19
HIS A 291
 None
 1.36A 3pfgA-4kwsA:
undetectable		 3pfgA-4kwsA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 LEU A   3
ILE A  24
GLY A  32
ILE A  98
ASP A   7
 None
 1.08A 3uj7B-4kwsA:
undetectable		 3uj7B-4kwsA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 ALA A 302
ASN A 337
ASP A  92
ILE A  65
ARG A 299
 None
 1.43A 3w37A-4kwsA:
2.2		 3w37A-4kwsA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 ALA A 302
ASN A 337
ASP A  92
ILE A  65
ARG A 299
 None
 1.44A 3welA-4kwsA:
6.1		 3welA-4kwsA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 VAL A 394
TRP A 184
TRP A 403
 None
 1.27A 3zq8A-4kwsA:
undetectable
3zq8B-4kwsA:
undetectable		 3zq8A-4kwsA:
3.41
3zq8B-4kwsA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 9 ASP A  97
ILE A  98
GLY A  32
THR A  26
GLY A  29
 None
 1.25A 4acaB-4kwsA:
undetectable
4acaC-4kwsA:
undetectable		 4acaB-4kwsA:
22.49
4acaC-4kwsA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 10 ALA A 223
ILE A 253
ILE A 282
LEU A 276
ILE A 263
 None
 1.29A 4dtaA-4kwsA:
undetectable		 4dtaA-4kwsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 11 GLY A  34
ILE A  88
GLY A 294
ILE A 295
THR A  68
 None
 0.83A 4qgiA-4kwsA:
undetectable		 4qgiA-4kwsA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 5 PHE A 197
PRO A 232
VAL A 230
ALA A 198
 None
 1.34A 4w5oA-4kwsA:
undetectable		 4w5oA-4kwsA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 5 PHE A 197
PRO A 232
VAL A 230
ALA A 198
 None
 1.35A 4z4eA-4kwsA:
undetectable		 4z4eA-4kwsA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 7 PHE A 236
ALA A 262
PRO A 260
LEU A 238
 None
 1.14A 5dzkD-4kwsA:
2.0
5dzkR-4kwsA:
undetectable		 5dzkD-4kwsA:
19.95
5dzkR-4kwsA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 GLY A  34
ILE A  88
GLY A 294
ILE A 295
THR A  68
 None
 0.80A 5kqxA-4kwsA:
undetectable		 5kqxA-4kwsA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 GLU A 131
LEU A 235
ALA A 199
ARG A 149
ARG A 203
 None
 1.05A 5nd3B-4kwsA:
2.3		 5nd3B-4kwsA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 GLU A 131
LEU A 235
ALA A 199
ARG A 149
ARG A 203
 None
 1.17A 5nd7B-4kwsA:
undetectable		 5nd7B-4kwsA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 7 GLY A 374
HIS A 373
HIS A  31
ASP A 376
 None
 1.03A 5nnwD-4kwsA:
undetectable		 5nnwD-4kwsA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 7 GLY A 374
HIS A 373
HIS A  31
ASP A 376
 None
 1.04A 5no9D-4kwsA:
undetectable		 5no9D-4kwsA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 8 THR A  84
ARG A  74
GLN A  70
TRP A  69
 CL  A 503 ( 4.8A)
None
None
None
 1.19A 5tzoB-4kwsA:
undetectable		 5tzoB-4kwsA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 6 TRP A 405
LEU A 320
ASP A 240
GLU A 265
 None
None
MG  A 501 ( 4.7A)
MG  A 501 ( 2.5A)
 1.48A 6djzC-4kwsA:
undetectable		 6djzC-4kwsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 6 TRP A 405
LEU A 320
TYR A 171
ASP A 213
 None
None
None
MG  A 501 (-2.6A)
 1.43A 6djzC-4kwsA:
undetectable		 6djzC-4kwsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4kws D-MANNONATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 8 GLY A 162
GLN A 151
THR A 126
TRP A 405
 None
 1.16A 6eqpA-4kwsA:
2.9		 6eqpA-4kwsA:
12.28