SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kxb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 ILE A 619
THR A 635
SER A 638
ILE A 639
LEU A 658
 None
 1.03A 1ddrA-4kxbA:
undetectable		 1ddrA-4kxbA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 GLU A 334
TYR A 341
PHE A 330
 None
 0.76A 1eqbB-4kxbA:
undetectable		 1eqbB-4kxbA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 GLU A 334
TYR A 341
PHE A 330
 None
 0.76A 1eqbA-4kxbA:
undetectable		 1eqbA-4kxbA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 GLU A 334
TYR A 341
PHE A 330
 None
 0.75A 1eqbD-4kxbA:
undetectable		 1eqbD-4kxbA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 GLU A 334
TYR A 341
PHE A 330
 None
 0.76A 1eqbC-4kxbA:
undetectable		 1eqbC-4kxbA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 GLN A 398
TYR A 367
ARG A 368
 None
 0.89A 1gtbA-4kxbA:
undetectable		 1gtbA-4kxbA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 8 LEU A 812
SER A 379
SER A 381
ASN A 383
 None
 1.12A 1ig3A-4kxbA:
undetectable
1ig3B-4kxbA:
undetectable		 1ig3A-4kxbA:
14.77
1ig3B-4kxbA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.82A 1j36A-4kxbA:
6.8		 1j36A-4kxbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.83A 1j36B-4kxbA:
3.8		 1j36B-4kxbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 11 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.80A 1j37A-4kxbA:
3.8		 1j37A-4kxbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 11 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.81A 1j37B-4kxbA:
6.8		 1j37B-4kxbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.78A 1o86A-4kxbA:
4.0		 1o86A-4kxbA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 TRP A 938
ASN A 900
LEU A 939
PHE A 706
 None
 1.43A 1ru9H-4kxbA:
2.3
1ru9L-4kxbA:
undetectable		 1ru9H-4kxbA:
14.53
1ru9L-4kxbA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 TRP A 938
ASN A 900
LEU A 939
PHE A 706
 None
 1.48A 1rukH-4kxbA:
2.3
1rukL-4kxbA:
undetectable		 1rukH-4kxbA:
14.53
1rukL-4kxbA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 ARG A 947
ARG A 943
ILE A 716
 None
 0.78A 1uobA-4kxbA:
undetectable		 1uobA-4kxbA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 0.98A 1v54A-4kxbA:
undetectable
1v54J-4kxbA:
undetectable		 1v54A-4kxbA:
20.00
1v54J-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 11 ILE A 470
MET A 406
ASP A 411
GLY A 417
TYR A 285
 None
 1.20A 2azyA-4kxbA:
undetectable		 2azyA-4kxbA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		6 / 12 ALA A 358
HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 BES  A1017 (-4.6A)
ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.75A 2c6nA-4kxbA:
3.9		 2c6nA-4kxbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.82A 2c6nB-4kxbA:
undetectable		 2c6nB-4kxbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 0.90A 2dysN-4kxbA:
undetectable
2dysW-4kxbA:
undetectable		 2dysN-4kxbA:
20.00
2dysW-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 0.96A 2eijA-4kxbA:
undetectable
2eijJ-4kxbA:
undetectable		 2eijA-4kxbA:
20.00
2eijJ-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 0.96A 2eilA-4kxbA:
undetectable
2eilJ-4kxbA:
undetectable		 2eilA-4kxbA:
20.00
2eilJ-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 5 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 0.90A 2eimJ-4kxbA:
undetectable		 2eimJ-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 5 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 0.92A 2eimW-4kxbA:
undetectable		 2eimW-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 0.93A 2einN-4kxbA:
undetectable
2einW-4kxbA:
undetectable		 2einN-4kxbA:
20.00
2einW-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 GLU A 360
HIS A 393
GLU A 394
 BES  A1017 (-2.9A)
ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
 0.88A 2x45C-4kxbA:
undetectable		 2x45C-4kxbA:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 11 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.72A 2x8zA-4kxbA:
8.0		 2x8zA-4kxbA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.75A 2x91A-4kxbA:
5.7		 2x91A-4kxbA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 8 VAL A 287
TYR A 243
VAL A 106
TYR A 115
 None
 1.30A 2y05A-4kxbA:
undetectable
2y05B-4kxbA:
undetectable		 2y05A-4kxbA:
16.80
2y05B-4kxbA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		6 / 12 ILE A 121
ILE A 123
ILE A 141
MET A 190
VAL A 157
VAL A 155
 None
 1.31A 2ygoA-4kxbA:
undetectable		 2ygoA-4kxbA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 ILE A 121
ILE A 123
MET A 190
VAL A 157
VAL A 155
 None
 1.08A 2ygpA-4kxbA:
undetectable		 2ygpA-4kxbA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 GLY A 551
ILE A 555
ASN A 554
VAL A 629
LEU A 617
 None
 1.06A 2zzmA-4kxbA:
undetectable		 2zzmA-4kxbA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 5 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 1.10A 3ag1J-4kxbA:
undetectable		 3ag1J-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 5 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 0.97A 3ag2J-4kxbA:
undetectable		 3ag2J-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 7 GLY A 194
ASP A 113
TYR A 115
ARG A 205
 None
 1.17A 3arrA-4kxbA:
2.3		 3arrA-4kxbA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 7 GLY A 194
ASP A 113
TYR A 115
ARG A 205
 None
 1.13A 3aruA-4kxbA:
undetectable		 3aruA-4kxbA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 10 GLY A 551
ILE A 555
ASN A 554
VAL A 629
LEU A 617
 None
 1.11A 3ay0B-4kxbA:
undetectable		 3ay0B-4kxbA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 HIS A 393
GLU A 394
HIS A 397
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
 0.21A 3kecB-4kxbA:
4.6		 3kecB-4kxbA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 9 TYR A 336
PHE A 422
VAL A 396
ASN A 428
GLY A 426
 None
 1.48A 3km6B-4kxbA:
1.1		 3km6B-4kxbA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 7 PHE A 422
PHE A 333
GLY A 501
PHE A 424
 None
 1.08A 3ko0R-4kxbA:
undetectable
3ko0T-4kxbA:
undetectable		 3ko0R-4kxbA:
7.75
3ko0T-4kxbA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 10 ILE A 121
ALA A 241
PHE A 234
SER A 126
ILE A 123
 None
 1.16A 3qgtB-4kxbA:
undetectable		 3qgtB-4kxbA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 8 PHE A 337
ASN A 415
PHE A 400
ALA A 419
 None
None
None
ZN  A1001 ( 4.2A)
 0.98A 3t3sF-4kxbA:
undetectable		 3t3sF-4kxbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 11 THR A 471
VAL A 201
GLU A 167
VAL A 879
THR A 883
 None
 1.33A 3tbgA-4kxbA:
2.3		 3tbgA-4kxbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 10 THR A 471
VAL A 201
GLU A 167
VAL A 879
THR A 883
 None
 1.28A 3tbgC-4kxbA:
2.3		 3tbgC-4kxbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 ARG A 628
GLN A 449
TYR A 544
LEU A 562
 None
 1.30A 3tgvD-4kxbA:
undetectable		 3tgvD-4kxbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 ARG A 487
PRO A 495
PHE A 421
 None
 0.88A 3thrC-4kxbA:
undetectable		 3thrC-4kxbA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 PHE A 424
SER A 483
SER A 420
 None
 0.92A 3ufgB-4kxbA:
undetectable		 3ufgB-4kxbA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 LYS A 229
GLU A 138
TRP A 195
 None
NAG  A1002 (-3.7A)
NAG  A1002 (-4.0A)
 0.96A 3v4tH-4kxbA:
undetectable		 3v4tH-4kxbA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 HIS A 397
GLY A 417
ASN A 415
ALA A 522
PHE A 337
 ZN  A1001 ( 3.2A)
None
None
None
None
 1.03A 3vywC-4kxbA:
undetectable		 3vywC-4kxbA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 0.88A 3wg7N-4kxbA:
undetectable
3wg7W-4kxbA:
undetectable		 3wg7N-4kxbA:
20.00
3wg7W-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 11 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.81A 4c2pA-4kxbA:
3.1		 4c2pA-4kxbA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 PHE A 400
PHE A 337
VAL A 404
PHE A 422
GLN A 499
 None
 1.47A 4c9wA-4kxbA:
undetectable		 4c9wA-4kxbA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 ILE A 619
THR A 635
SER A 638
ILE A 639
LEU A 658
 None
 1.05A 4dfrA-4kxbA:
undetectable		 4dfrA-4kxbA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 9 GLY A 357
HIS A 393
GLU A 394
GLU A 416
TYR A 479
 BES  A1017 (-3.0A)
ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.45A 4dprA-4kxbA:
31.4		 4dprA-4kxbA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 7 PHE A 400
GLY A 501
LEU A 486
PHE A 422
 None
 0.91A 4ejjD-4kxbA:
undetectable		 4ejjD-4kxbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 10 ILE A 121
ALA A 241
PHE A 234
SER A 126
ILE A 123
 None
 1.20A 4g8zX-4kxbA:
undetectable		 4g8zX-4kxbA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 4 VAL A 261
THR A 275
GLU A 264
GLU A 265
 None
 1.02A 4l78A-4kxbA:
undetectable		 4l78A-4kxbA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 VAL A 629
LEU A 671
THR A 635
ILE A 639
LEU A 658
 None
 1.24A 4o5fA-4kxbA:
undetectable
4o5fB-4kxbA:
undetectable		 4o5fA-4kxbA:
15.04
4o5fB-4kxbA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 LEU A 658
VAL A 629
LEU A 671
THR A 635
ILE A 639
 None
 1.25A 4o5fA-4kxbA:
undetectable
4o5fB-4kxbA:
undetectable		 4o5fA-4kxbA:
15.04
4o5fB-4kxbA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 LEU A 486
HIS A 397
HIS A 393
GLU A 416
 None
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 2.4A)
 1.00A 4pahA-4kxbA:
undetectable		 4pahA-4kxbA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 THR A 539
ASN A 415
PHE A 400
 None
 0.68A 4pd9A-4kxbA:
2.6		 4pd9A-4kxbA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 GLU A 394
HIS A 397
TRP A 409
PHE A 474
GLU A 416
 BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
None
BES  A1017 (-3.7A)
ZN  A1001 ( 2.4A)
 1.41A 4r7lA-4kxbA:
40.5		 4r7lA-4kxbA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		6 / 12 HIS A 393
GLU A 394
HIS A 397
TRP A 409
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
None
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.41A 4r7lA-4kxbA:
40.5		 4r7lA-4kxbA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 7 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 0.85A 5b1bN-4kxbA:
undetectable
5b1bW-4kxbA:
undetectable		 5b1bN-4kxbA:
20.00
5b1bW-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 7 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 0.82A 5b3sN-4kxbA:
undetectable
5b3sW-4kxbA:
undetectable		 5b3sN-4kxbA:
20.00
5b3sW-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 VAL A 629
LEU A 671
THR A 635
ILE A 639
LEU A 658
 None
 1.25A 5b8hA-4kxbA:
2.1
5b8hB-4kxbA:
undetectable		 5b8hA-4kxbA:
15.09
5b8hB-4kxbA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 GLU A 236
TRP A 133
ASN A  98
 None
 0.65A 5dv4A-4kxbA:
undetectable		 5dv4A-4kxbA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 5 GLU A 360
ALA A 358
GLU A 394
GLU A 416
 BES  A1017 (-2.9A)
BES  A1017 (-4.6A)
BES  A1017 (-3.1A)
ZN  A1001 ( 2.4A)
 1.36A 5dwkC-4kxbA:
undetectable		 5dwkC-4kxbA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 ARG A 368
THR A 852
ASP A 849
 None
 0.70A 5g5gA-4kxbA:
undetectable
5g5gB-4kxbA:
undetectable		 5g5gA-4kxbA:
13.62
5g5gB-4kxbA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 11 LEU A 606
GLY A 551
ILE A 555
ASN A 554
VAL A 629
 None
 1.17A 5hjiA-4kxbA:
undetectable		 5hjiA-4kxbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 VAL A 448
SER A 420
MET A 436
 None
 0.86A 5ikqA-4kxbA:
undetectable		 5ikqA-4kxbA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 8 ARG A 137
GLU A 167
PRO A 467
ASP A 468
 None
 1.11A 5kf8A-4kxbA:
undetectable		 5kf8A-4kxbA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 GLU A 167
ARG A 137
LEU A 136
ARG A 228
 None
 1.09A 5l6eA-4kxbA:
undetectable
5l6eB-4kxbA:
undetectable		 5l6eA-4kxbA:
11.97
5l6eB-4kxbA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 ILE A 309
GLN A 398
ILE A 325
ALA A 323
VAL A 391
 None
 1.11A 5n0sB-4kxbA:
undetectable		 5n0sB-4kxbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 TYR A 915
ASP A 468
LEU A 884
GLY A 919
 None
 1.06A 5nooC-4kxbA:
undetectable		 5nooC-4kxbA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 VAL A 404
TYR A 509
GLN A 510
 None
 0.68A 5qgkA-4kxbA:
undetectable		 5qgkA-4kxbA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 VAL A 404
TYR A 509
GLN A 510
 None
 0.72A 5qgrA-4kxbA:
undetectable		 5qgrA-4kxbA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 VAL A 404
TYR A 509
GLN A 510
 None
 0.74A 5qgtA-4kxbA:
undetectable		 5qgtA-4kxbA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 LEU A 486
ALA A 392
PHE A 337
PHE A 333
LEU A 506
 None
 1.07A 5tudA-4kxbA:
undetectable		 5tudA-4kxbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 8 ILE A 895
TRP A 868
GLN A 904
VAL A 928
 None
 1.17A 5vlmF-4kxbA:
undetectable		 5vlmF-4kxbA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 5 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 0.97A 5w97J-4kxbA:
undetectable		 5w97J-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 5 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 0.97A 5wauJ-4kxbA:
undetectable		 5wauJ-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 5 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 0.87A 5z86J-4kxbA:
undetectable		 5z86J-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 0.84A 5z86N-4kxbA:
0.5
5z86W-4kxbA:
undetectable		 5z86N-4kxbA:
20.00
5z86W-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 0.86A 5zcoN-4kxbA:
0.3
5zcoW-4kxbA:
undetectable		 5zcoN-4kxbA:
20.00
5zcoW-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 9 ALA A 419
SER A 420
VAL A 390
ALA A 392
GLY A 426
 ZN  A1001 ( 4.2A)
None
BES  A1017 ( 3.7A)
None
None
 1.10A 6bklA-4kxbA:
undetectable
6bklB-4kxbA:
undetectable
6bklC-4kxbA:
undetectable
6bklD-4kxbA:
undetectable		 6bklA-4kxbA:
3.10
6bklB-4kxbA:
3.10
6bklC-4kxbA:
3.10
6bklD-4kxbA:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 7 SER A 230
HIS A 222
GLY A 202
LEU A 104
 None
 1.12A 6btxA-4kxbA:
1.5		 6btxA-4kxbA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 THR A 225
GLU A 138
ASN A 885
 None
NAG  A1002 (-3.7A)
None
 0.88A 6nj9K-4kxbA:
undetectable		 6nj9K-4kxbA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 5 ARG A 143
MET A 190
THR A 189
LEU A 188
 None
 1.02A 6nknW-4kxbA:
undetectable		 6nknW-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 LEU A 486
HIS A 397
HIS A 393
GLU A 416
 None
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 2.4A)
 1.02A 6pahA-4kxbA:
undetectable		 6pahA-4kxbA:
17.03