SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kxr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4kxr ESPG5
(Mycobacterium
tuberculosis) 		5 / 10 ALA C 273
LEU C 242
SER C 240
ALA C 269
ILE C 252
 None
 1.11A 1g5yC-4kxrC:
undetectable		 1g5yC-4kxrC:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4kxr PPE41
ESPG5
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		4 / 6 ILE B 109
PRO B   8
GLU B   9
ARG C 109
 None
 1.39A 1oniA-4kxrB:
undetectable
1oniC-4kxrB:
undetectable		 1oniA-4kxrB:
19.79
1oniC-4kxrB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4kxr PPE41
ESPG5
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		4 / 5 ARG C 109
ILE B 109
PRO B   8
GLU B   9
 None
 1.46A 1oniG-4kxrC:
undetectable
1oniH-4kxrC:
undetectable		 1oniG-4kxrC:
20.13
1oniH-4kxrC:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4kxr ESPG5
(Mycobacterium
tuberculosis) 		4 / 7 GLY C 196
SER C 185
SER C 189
GLU C 188
 None
 1.10A 2c8aD-4kxrC:
undetectable		 2c8aD-4kxrC:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 4kxr PPE41
ESPG5
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		5 / 12 ARG C  34
GLU C 115
ARG C 117
LEU B 119
ARG B 113
 None
 1.32A 2f10A-4kxrC:
undetectable		 2f10A-4kxrC:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4kxr ESPG5
(Mycobacterium
tuberculosis) 		4 / 6 ALA C  22
ASP C  25
ARG C  36
MET C  56
 None
 1.11A 2ouzA-4kxrC:
undetectable		 2ouzA-4kxrC:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 4kxr ESPG5
(Mycobacterium
tuberculosis) 		5 / 11 VAL C 139
ILE C 137
GLY C  16
VAL C  71
ILE C  10
 None
 0.91A 3lzvB-4kxrC:
undetectable		 3lzvB-4kxrC:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 4kxr ESPG5
(Mycobacterium
tuberculosis) 		5 / 10 VAL C 139
ILE C 137
GLY C  16
VAL C  71
ILE C  10
 None
 0.88A 3nujA-4kxrC:
undetectable		 3nujA-4kxrC:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4kxr PPE41
(Mycobacterium
tuberculosis) 		4 / 8 ARG B  94
GLU B  91
GLU B  86
ARG B  32
 None
 1.10A 4bqfB-4kxrB:
undetectable		 4bqfB-4kxrB:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4kxr PPE41
(Mycobacterium
tuberculosis) 		4 / 8 ASN B  11
MET B 103
GLU B 148
GLU B   4
 None
 1.19A 4mj8A-4kxrB:
undetectable
4mj8C-4kxrB:
undetectable		 4mj8A-4kxrB:
23.41
4mj8C-4kxrB:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4kxr PPE41
(Mycobacterium
tuberculosis) 		4 / 7 ASN B  11
MET B 103
GLU B 148
GLU B   4
 None
 1.16A 4mj8C-4kxrB:
undetectable		 4mj8C-4kxrB:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 4kxr PPE41
(Mycobacterium
tuberculosis) 		3 / 3 TYR B  96
GLY B  20
PRO B  21
 None
 0.65A 4qwpA-4kxrB:
undetectable		 4qwpA-4kxrB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4kxr PPE41
ESPG5
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		3 / 3 ASP B 121
ARG C  34
ARG B 113
 None
 0.98A 4x5iA-4kxrB:
undetectable		 4x5iA-4kxrB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 4kxr ESPG5
(Mycobacterium
tuberculosis) 		4 / 6 ILE C  99
ARG C  34
ILE C 111
GLU C 115
 None
 1.35A 4zzcA-4kxrC:
undetectable
4zzcB-4kxrC:
undetectable		 4zzcA-4kxrC:
22.82
4zzcB-4kxrC:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 4kxr ESPG5
(Mycobacterium
tuberculosis) 		4 / 6 ILE C  99
ARG C  34
ILE C 111
GLU C 115
 None
 1.42A 4zzcB-4kxrC:
undetectable
4zzcC-4kxrC:
undetectable		 4zzcB-4kxrC:
22.82
4zzcC-4kxrC:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4kxr PPE41
ESPG5
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		3 / 3 ASP B 134
ARG C 109
ARG C 117
 None
 0.96A 5eajB-4kxrB:
undetectable		 5eajB-4kxrB:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 4kxr ESPG5
(Mycobacterium
tuberculosis) 		5 / 12 ILE C 150
VAL C 119
VAL C 118
LEU C 286
LEU C  83
 None
 1.17A 6b52A-4kxrC:
undetectable		 6b52A-4kxrC:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4kxr ESPG5
(Mycobacterium
tuberculosis) 		3 / 3 ILE C  99
ASN C 135
CYH C  35
 None
 0.61A 6bp4A-4kxrC:
undetectable		 6bp4A-4kxrC:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kxr ESPG5
(Mycobacterium
tuberculosis) 		3 / 3 LEU C 268
GLN C 256
LYS C 245
 None
 0.92A 6exiB-4kxrC:
undetectable		 6exiB-4kxrC:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4kxr ESPG5
(Mycobacterium
tuberculosis) 		3 / 3 LEU C 268
GLN C 256
LYS C 245
 None
 0.98A 6exiA-4kxrC:
undetectable		 6exiA-4kxrC:
15.75