SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kxz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA4_A_CTXA11_1 (CES1 PROTEIN)	4kxz	GC1008 HEAVY CHAIN (Homo sapiens)	4 / 8	PRO H 133 LEU H 196 GLY H 197 LEU H 145	None	0.92A	1ya4A-4kxzH: undetectable	1ya4A-4kxzH: 17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B2R_B_VDNB1_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	4kxz	GC1008 HEAVY CHAIN TRANSFORMING GROWTH FACTOR BETA-2 (Homo sapiens)	5 / 11	ILE A 88 ALA A 41 ILE A 22 ILE H 54 PHE A 24	None	1.15A	3b2rB-4kxzA: undetectable	3b2rB-4kxzA: 15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YO9_B_ACTB401_0 (3C-LIKE PROTEINASE)	4kxz	TRANSFORMING GROWTH FACTOR BETA-2 (Homo sapiens)	3 / 3	ARG A 26 ASP A 27 TYR A 21	None	0.71A	4yo9B-4kxzA: undetectable	4yo9B-4kxzA: 16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ECM_D_LEUD602_0 (JASMONIC ACID-AMIDO SYNTHETASE JAR1)	4kxz	GC1008 HEAVY CHAIN (Homo sapiens)	4 / 7	ALA H 92 THR H 91 VAL H 116 GLU H 89	None	0.76A	5ecmD-4kxzH: undetectable	5ecmD-4kxzH: 16.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5MTH_A_ACTA302_0 (ANTIBODY FAB HEAVY CHAIN)	4kxz	GC1008 HEAVY CHAIN (Homo sapiens)	4 / 5	SER H 119 ALA H 121 PHE H 153 LEU H 177	None	0.35A	5mthA-4kxzH: 27.1	5mthA-4kxzH: 61.26

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1YA4_A_CTXA11_1","CES1 PROTEIN","4kxz","GC1008 HEAVY CHAIN","Homo sapiens",4,"PRO H 133;LEU H 196;GLY H 197;LEU H 145","None","0.92A","1ya4A-4kxzH:undetectable","1ya4A-4kxzH:17.01"],["3B2R_B_VDNB1_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","4kxz","GC1008 HEAVY CHAIN;TRANSFORMING GROWTH FACTOR BETA-2","Homo sapiens",5,"ILE A  88;ALA A  41;ILE A  22;ILE H  54;PHE A  24","None","1.15A","3b2rB-4kxzA:undetectable","3b2rB-4kxzA:15.81"],["4YO9_B_ACTB401_0","3C-LIKE PROTEINASE","4kxz","TRANSFORMING GROWTH FACTOR BETA-2","Homo sapiens",3,"ARG A  26;ASP A  27;TYR A  21","None","0.71A","4yo9B-4kxzA:undetectable","4yo9B-4kxzA:16.94"],["5ECM_D_LEUD602_0","JASMONIC ACID-AMIDO SYNTHETASE JAR1","4kxz","GC1008 HEAVY CHAIN","Homo sapiens",4,"ALA H  92;THR H  91;VAL H 116;GLU H  89","None","0.76A","5ecmD-4kxzH:undetectable","5ecmD-4kxzH:16.88"],["5MTH_A_ACTA302_0","ANTIBODY FAB HEAVY CHAIN","4kxz","GC1008 HEAVY CHAIN","Homo sapiens",4,"SER H 119;ALA H 121;PHE H 153;LEU H 177","None","0.35A","5mthA-4kxzH:27.1","5mthA-4kxzH:61.26"]]