SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ky0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.01A 1cqeA-4ky0A:
1.7		 1cqeA-4ky0A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.01A 1cqeB-4ky0A:
undetectable		 1cqeB-4ky0A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		4 / 7 GLY A 102
GLN A 244
ILE A 104
VAL A 105
 None
 1.00A 1rxcC-4ky0A:
undetectable		 1rxcC-4ky0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		4 / 8 GLY A 102
GLN A 244
ILE A 104
VAL A 105
 None
 0.98A 1rxcI-4ky0A:
undetectable		 1rxcI-4ky0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.02A 2aylA-4ky0A:
undetectable		 2aylA-4ky0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.00A 2aylB-4ky0A:
undetectable		 2aylB-4ky0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 LEU A 342
LEU A 346
GLY A 322
ARG A 107
ALA A 329
 None
 1.18A 2br4D-4ky0A:
undetectable		 2br4D-4ky0A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 ILE A 162
PHE A 263
ALA A 267
ALA A 270
THR A 283
 None
 1.24A 2x2nD-4ky0A:
undetectable		 2x2nD-4ky0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 ILE A 165
PHE A 263
ALA A 267
ALA A 270
THR A 283
 None
 1.25A 2x2nD-4ky0A:
undetectable		 2x2nD-4ky0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		4 / 7 THR A 273
VAL A 276
THR A 277
THR A 283
 None
 0.84A 3deuA-4ky0A:
0.7		 3deuA-4ky0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		4 / 5 PRO A 155
VAL A 156
THR A 283
GLY A 282
 None
 1.18A 3elzB-4ky0A:
undetectable		 3elzB-4ky0A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		4 / 7 VAL A 290
VAL A 414
PHE A 263
GLU A 294
 None
 1.13A 3jx6A-4ky0A:
0.2
3jx6B-4ky0A:
0.4		 3jx6A-4ky0A:
21.17
3jx6B-4ky0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		3 / 3 ALA A  78
ARG A  82
LYS A  86
 None
PG4  A 501 (-4.8A)
PG4  A 501 (-4.5A)
 0.86A 3kp5B-4ky0A:
undetectable		 3kp5B-4ky0A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		4 / 6 GLY A 102
GLN A 244
ILE A 104
VAL A 105
 None
 0.99A 3kvvD-4ky0A:
undetectable		 3kvvD-4ky0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 9 TYR A 249
PHE A 263
ALA A 267
ALA A 270
THR A 283
 None
 1.36A 3l4dC-4ky0A:
undetectable		 3l4dC-4ky0A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.01A 3n8wA-4ky0A:
undetectable		 3n8wA-4ky0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.04A 3n8zA-4ky0A:
1.5		 3n8zA-4ky0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.02A 3n8zB-4ky0A:
undetectable		 3n8zB-4ky0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		4 / 7 PHE A 263
GLU A 294
VAL A 290
VAL A 414
 None
 1.10A 3nljA-4ky0A:
0.5
3nljB-4ky0A:
undetectable		 3nljA-4ky0A:
21.17
3nljB-4ky0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 9 GLY A 210
ALA A 213
VAL A  41
GLY A  25
ILE A  45
 None
 0.92A 3nuoB-4ky0A:
undetectable		 3nuoB-4ky0A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 9 GLY A 210
ALA A 213
VAL A  41
GLY A  25
ILE A  45
 None
 0.93A 3oxvC-4ky0A:
undetectable		 3oxvC-4ky0A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 11 ILE A 161
PRO A  77
SER A  76
ILE A  75
PHE A 304
 None
 1.26A 3rf4A-4ky0A:
undetectable
3rf4B-4ky0A:
undetectable		 3rf4A-4ky0A:
15.24
3rf4B-4ky0A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 11 ILE A 161
PRO A  77
SER A  76
ILE A  75
PHE A 304
 None
 1.25A 3rf4B-4ky0A:
undetectable
3rf4C-4ky0A:
undetectable		 3rf4B-4ky0A:
15.24
3rf4C-4ky0A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.04A 4otyB-4ky0A:
undetectable		 4otyB-4ky0A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 VAL A 416
SER A 303
PHE A 304
GLY A  84
GLY A 300
 None
 1.24A 4pevB-4ky0A:
undetectable		 4pevB-4ky0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 9 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.04A 4rs0A-4ky0A:
undetectable		 4rs0A-4ky0A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 9 GLY A 210
ALA A 213
VAL A  41
GLY A  25
ILE A  45
 None
 0.91A 4rvjB-4ky0A:
undetectable		 4rvjB-4ky0A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 9 GLY A 210
ALA A 213
VAL A  41
GLY A  25
ILE A  45
 None
 0.92A 4rvjD-4ky0A:
undetectable		 4rvjD-4ky0A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 GLY A  21
ASP A 269
VAL A 276
THR A 277
VAL A 203
 None
 1.03A 4wnwA-4ky0A:
undetectable		 4wnwA-4ky0A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		4 / 5 LEU A  68
THR A 413
VAL A  83
ILE A  87
 None
 0.88A 4xe3B-4ky0A:
1.2		 4xe3B-4ky0A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 VAL A 297
GLY A 300
VAL A 153
LEU A 284
PRO A 285
 None
 1.04A 5ergB-4ky0A:
undetectable		 5ergB-4ky0A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.04A 5ikqA-4ky0A:
undetectable		 5ikqA-4ky0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.12A 5ikrA-4ky0A:
undetectable		 5ikrA-4ky0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.02A 5ikrB-4ky0A:
undetectable		 5ikrB-4ky0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.07A 5kirA-4ky0A:
undetectable		 5kirA-4ky0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 10 PRO A  77
ASP A 298
LYS A 421
SER A  74
GLY A 164
 None
 1.37A 5weoA-4ky0A:
1.8
5weoD-4ky0A:
undetectable		 5weoA-4ky0A:
19.30
5weoD-4ky0A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_B_CYZB1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 9 PRO A  77
ASP A 298
LYS A 421
SER A  74
GLY A 164
 None
 1.37A 5weoB-4ky0A:
0.2
5weoC-4ky0A:
0.1		 5weoB-4ky0A:
19.30
5weoC-4ky0A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_C_CYZC1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 9 SER A  74
GLY A 164
PRO A  77
ASP A 298
LYS A 421
 None
 1.40A 5weoB-4ky0A:
0.2
5weoC-4ky0A:
0.9		 5weoB-4ky0A:
19.30
5weoC-4ky0A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_D_CYZD1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 9 SER A  74
GLY A 164
PRO A  77
ASP A 298
LYS A 421
 None
 1.38A 5weoA-4ky0A:
0.3
5weoD-4ky0A:
0.3		 5weoA-4ky0A:
19.30
5weoD-4ky0A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 12 ILE A 157
ALA A 160
PHE A 304
LEU A  68
ILE A 312
 None
 1.18A 6a5zD-4ky0A:
undetectable		 6a5zD-4ky0A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 10 PRO A  77
ASP A 298
ILE A 161
SER A  74
GLY A 164
 None
 1.41A 6dlzA-4ky0A:
undetectable
6dlzD-4ky0A:
undetectable		 6dlzA-4ky0A:
13.44
6dlzD-4ky0A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 10 PRO A  77
ASP A 298
LYS A 421
SER A  74
GLY A 164
 None
 1.31A 6dlzA-4ky0A:
undetectable
6dlzD-4ky0A:
undetectable		 6dlzA-4ky0A:
13.44
6dlzD-4ky0A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 10 ILE A 161
SER A  74
GLY A 164
PRO A  77
ASP A 298
 None
 1.41A 6dlzB-4ky0A:
2.0
6dlzC-4ky0A:
undetectable		 6dlzB-4ky0A:
13.44
6dlzC-4ky0A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 10 SER A  74
GLY A 164
PRO A  77
ASP A 298
LYS A 421
 None
 1.31A 6dlzB-4ky0A:
2.0
6dlzC-4ky0A:
undetectable		 6dlzB-4ky0A:
13.44
6dlzC-4ky0A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 10 PRO A  77
ASP A 298
ILE A 161
SER A  74
GLY A 164
 None
 1.42A 6dm1A-4ky0A:
undetectable
6dm1D-4ky0A:
2.0		 6dm1A-4ky0A:
13.44
6dm1D-4ky0A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 10 PRO A  77
ASP A 298
LYS A 421
SER A  74
GLY A 164
 None
 1.32A 6dm1A-4ky0A:
undetectable
6dm1D-4ky0A:
2.0		 6dm1A-4ky0A:
13.44
6dm1D-4ky0A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 10 ILE A 161
SER A  74
GLY A 164
PRO A  77
ASP A 298
 None
 1.42A 6dm1B-4ky0A:
undetectable
6dm1C-4ky0A:
undetectable		 6dm1B-4ky0A:
13.44
6dm1C-4ky0A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY
(Thermococcus
kodakarensis) 		5 / 10 SER A  74
GLY A 164
PRO A  77
ASP A 298
LYS A 421
 None
 1.31A 6dm1B-4ky0A:
undetectable
6dm1C-4ky0A:
undetectable		 6dm1B-4ky0A:
13.44
6dm1C-4ky0A:
13.44