SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kyi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4kyi VIPD
(Legionella
pneumophila) 		5 / 12 ILE A 291
GLY A 290
GLY A  42
SER A  41
VAL A 240
 None
 1.00A 1vq1B-4kyiA:
2.1		 1vq1B-4kyiA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 4kyi VIPD
(Legionella
pneumophila) 		5 / 12 THR A 180
LEU A 179
ILE A 176
VAL A 173
LEU A 163
 None
 1.35A 1wsvA-4kyiA:
undetectable		 1wsvA-4kyiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 4kyi VIPD
(Legionella
pneumophila) 		5 / 12 THR A 180
LEU A 179
ILE A 176
VAL A 173
LEU A 163
 None
 1.34A 1wsvB-4kyiA:
undetectable		 1wsvB-4kyiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4kyi VIPD
(Legionella
pneumophila) 		4 / 8 SER A  80
ARG A 222
LEU A 218
GLU A 253
 None
 0.93A 2cdqA-4kyiA:
undetectable		 2cdqA-4kyiA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 4kyi VIPD
(Legionella
pneumophila) 		4 / 7 SER A  80
ARG A 222
LEU A 218
GLU A 253
 None
 1.01A 2cdqB-4kyiA:
undetectable		 2cdqB-4kyiA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4kyi VIPD
(Legionella
pneumophila) 		3 / 3 ARG A 112
ASP A 116
ASP A 123
 None
 0.77A 2ejtA-4kyiA:
undetectable		 2ejtA-4kyiA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4kyi VIPD
(Legionella
pneumophila) 		5 / 10 LEU A  94
ILE A 100
SER A  80
PHE A 118
THR A 180
 None
 1.16A 2w9sD-4kyiA:
undetectable		 2w9sD-4kyiA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4kyi VIPD
(Legionella
pneumophila) 		5 / 10 LEU A  94
ILE A 100
SER A  80
PHE A 118
THR A 180
 None
 1.16A 2w9sF-4kyiA:
undetectable		 2w9sF-4kyiA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4kyi VIPD
(Legionella
pneumophila) 		4 / 8 TYR A 422
LEU A 421
LEU A 498
LYS A 501
 None
 0.97A 2wekA-4kyiA:
undetectable		 2wekA-4kyiA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4kyi VIPD
(Legionella
pneumophila) 		4 / 6 ARG A 112
SER A 107
ASP A 116
PRO A 277
 None
 1.49A 3jqaD-4kyiA:
undetectable		 3jqaD-4kyiA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4kyi VIPD
(Legionella
pneumophila) 		4 / 6 ILE A 233
LEU A 224
HIS A 133
LEU A 134
 None
 0.93A 3kp6A-4kyiA:
undetectable
3kp6B-4kyiA:
undetectable		 3kp6A-4kyiA:
14.92
3kp6B-4kyiA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4kyi VIPD
(Legionella
pneumophila) 		4 / 6 TYR A  50
GLY A  75
THR A  78
LEU A  82
 None
 1.03A 3ps9A-4kyiA:
3.1		 3ps9A-4kyiA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4kyi VIPD
(Legionella
pneumophila) 		4 / 6 ASN A 178
ILE A 121
ILE A 176
VAL A 124
 None
 0.99A 4olmA-4kyiA:
undetectable		 4olmA-4kyiA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 4kyi VIPD
(Legionella
pneumophila) 		5 / 12 LEU A 405
ASN A 370
CYH A 308
TYR A 366
SER A 408
 None
 1.48A 4ot2A-4kyiA:
3.7		 4ot2A-4kyiA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 4kyi VIPD
(Legionella
pneumophila) 		5 / 10 LEU A  98
LEU A 103
ASN A 120
VAL A 124
LEU A 193
 None
 1.15A 4po0A-4kyiA:
3.7		 4po0A-4kyiA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 4kyi VIPD
(Legionella
pneumophila) 		5 / 12 LEU A 405
ASN A 370
CYH A 308
TYR A 366
SER A 408
 None
 1.48A 4zbrA-4kyiA:
3.6		 4zbrA-4kyiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4kyi VIPD
(Legionella
pneumophila) 		4 / 6 GLU A 440
PHE A 413
THR A 412
TYR A  28
 None
 1.44A 5lrbA-4kyiA:
undetectable		 5lrbA-4kyiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 4kyi VIPD
(Legionella
pneumophila) 		5 / 12 ILE A  95
GLY A  75
THR A 402
ALA A  83
VAL A  84
 None
 1.12A 5x66F-4kyiA:
undetectable		 5x66F-4kyiA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 4kyi VIPD
(Legionella
pneumophila) 		5 / 12 VAL A 124
ILE A 170
ASN A 178
SER A 182
ILE A 168
 None
 1.49A 6gsdA-4kyiA:
undetectable		 6gsdA-4kyiA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4kyi VIPD
(Legionella
pneumophila) 		4 / 6 VAL A 306
ASN A 370
ASN A 367
ILE A 368
 None
 1.24A 6h7uA-4kyiA:
undetectable		 6h7uA-4kyiA:
21.39