SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kyz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4kyz DESIGNED PROTEIN
OR327
(synthetic
construct) 		4 / 6 LEU A  36
ALA A  45
ASP A  18
TYR A  19
 None
 1.36A 2dpzA-4kyzA:
undetectable		 2dpzA-4kyzA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 4kyz DESIGNED PROTEIN
OR327
(synthetic
construct) 		5 / 12 ILE A  10
VAL A   6
MET A  37
ILE A  66
VAL A  70
 None
 1.08A 3iw1A-4kyzA:
undetectable		 3iw1A-4kyzA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4kyz DESIGNED PROTEIN
OR327
(synthetic
construct) 		5 / 10 GLY A 160
LEU A  36
LEU A  74
ASN A  77
ILE A  40
 None
 1.20A 3wdmB-4kyzA:
undetectable		 3wdmB-4kyzA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4kyz DESIGNED PROTEIN
OR327
(synthetic
construct) 		5 / 9 GLY A 160
LEU A  36
LEU A  74
ASN A  77
ILE A  40
 None
 1.20A 3wdmC-4kyzA:
undetectable		 3wdmC-4kyzA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4kyz DESIGNED PROTEIN
OR327
(synthetic
construct) 		5 / 10 GLY A 160
LEU A  36
LEU A  74
ASN A  77
ILE A  40
 None
 1.11A 3wdmD-4kyzA:
undetectable		 3wdmD-4kyzA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 4kyz DESIGNED PROTEIN
OR327
(synthetic
construct) 		3 / 3 ASN A  16
ASP A  18
ASN A   9
 None
 0.79A 4agaA-4kyzA:
undetectable		 4agaA-4kyzA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4kyz DESIGNED PROTEIN
OR327
(synthetic
construct) 		3 / 3 ARG A  49
ASP A  18
ARG A  47
 None
 0.91A 4mx0A-4kyzA:
undetectable		 4mx0A-4kyzA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4kyz DESIGNED PROTEIN
OR327
(synthetic
construct) 		5 / 12 ILE A  40
TYR A  76
ARG A  47
PHE A  17
TYR A  19
 None
 1.43A 5igwA-4kyzA:
undetectable		 5igwA-4kyzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kyz DESIGNED PROTEIN
OR327
(synthetic
construct) 		3 / 3 VAL A  23
TYR A  21
GLN A   5
 None
 0.65A 5qgkA-4kyzA:
undetectable		 5qgkA-4kyzA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kyz DESIGNED PROTEIN
OR327
(synthetic
construct) 		3 / 3 VAL A  23
TYR A  21
GLN A   5
 None
 0.69A 5qgrA-4kyzA:
undetectable		 5qgrA-4kyzA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kyz DESIGNED PROTEIN
OR327
(synthetic
construct) 		3 / 3 VAL A  23
TYR A  21
GLN A   5
 None
 0.72A 5qgtA-4kyzA:
undetectable		 5qgtA-4kyzA:
22.69