SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 12 GLY A 103
GLY A 101
VAL A 133
LEU A 130
LEU A 122
None
1.09A 1mx1F-4kzkA:
3.1
1mx1F-4kzkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 12 THR A 209
ALA A 212
LEU A 170
ILE A 261
GLY A 260
None
0.93A 1qknA-4kzkA:
undetectable
1qknA-4kzkA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
4 / 5 ALA A 171
TYR A 172
ALA A 215
GLN A  41
None
1.14A 1xl6A-4kzkA:
undetectable
1xl6B-4kzkA:
undetectable
1xl6A-4kzkA:
21.93
1xl6B-4kzkA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
4 / 7 VAL A 199
ARG A 169
LEU A 189
THR A 182
None
1.17A 2f78B-4kzkA:
2.0
2f78B-4kzkA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
4 / 6 PHE A 220
ALA A 231
LEU A 170
ALA A 216
None
0.89A 2vcvB-4kzkA:
undetectable
2vcvB-4kzkA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 12 ALA A  54
GLU A  55
LEU A  65
ILE A 302
GLY A  90
None
1.19A 2yjaB-4kzkA:
undetectable
2yjaB-4kzkA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 12 ALA A 202
ALA A 171
ALA A 215
VAL A 147
ILE A 261
None
1.00A 3e00A-4kzkA:
undetectable
3e00A-4kzkA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
4 / 5 ASP A 132
ILE A 104
VAL A  91
THR A 294
None
1.20A 3eigA-4kzkA:
1.6
3eigA-4kzkA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
3 / 3 ASP A 124
ARG A 126
ALA A 128
None
0.78A 3mbgC-4kzkA:
undetectable
3mbgC-4kzkA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 12 GLY A 148
GLY A 144
ALA A 191
ALA A 192
LEU A 189
None
1.05A 3mteB-4kzkA:
2.5
3mteB-4kzkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 12 GLY A 148
GLY A 144
ALA A 191
ALA A 192
LEU A 189
None
1.01A 3p2kA-4kzkA:
2.5
3p2kA-4kzkA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 12 GLY A 148
GLY A 144
ALA A 191
ALA A 192
LEU A 189
None
1.01A 3p2kD-4kzkA:
undetectable
3p2kD-4kzkA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 9 ILE A 143
LEU A 331
ILE A 319
ILE A 283
THR A 314
None
1.24A 3tq8A-4kzkA:
undetectable
3tq8A-4kzkA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
4 / 6 GLY A 144
ILE A 143
GLN A 146
VAL A 259
None
1.13A 4d39B-4kzkA:
undetectable
4d39B-4kzkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 12 TRP A  51
ALA A  54
GLY A  36
LEU A  80
LEU A  83
None
0.95A 4lg1A-4kzkA:
undetectable
4lg1A-4kzkA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 12 TRP A  51
ALA A  54
GLY A  36
LEU A  80
LEU A  83
None
0.96A 4lg1B-4kzkA:
undetectable
4lg1B-4kzkA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 12 TRP A  51
ALA A  54
GLY A  36
LEU A  80
LEU A  83
None
0.94A 4lg1C-4kzkA:
undetectable
4lg1C-4kzkA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 11 ALA A  54
GLU A  55
LEU A  65
ILE A 302
GLY A  90
None
1.22A 4pxmB-4kzkA:
undetectable
4pxmB-4kzkA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 12 THR A 209
ALA A 212
LEU A 170
ILE A 261
GLY A 260
None
0.93A 4xi3B-4kzkA:
undetectable
4xi3B-4kzkA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
4 / 7 ARG A 244
GLY A 246
THR A 277
GLU A 247
None
0.88A 5bs8A-4kzkA:
undetectable
5bs8B-4kzkA:
4.1
5bs8C-4kzkA:
undetectable
5bs8A-4kzkA:
20.23
5bs8B-4kzkA:
22.65
5bs8C-4kzkA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
4 / 7 ARG A 244
GLY A 246
THR A 277
GLU A 247
None
0.92A 5btaA-4kzkA:
undetectable
5btaC-4kzkA:
undetectable
5btaD-4kzkA:
3.1
5btaA-4kzkA:
19.85
5btaC-4kzkA:
19.85
5btaD-4kzkA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
4 / 6 ARG A 244
GLY A 246
THR A 277
GLU A 247
None
0.89A 5btaA-4kzkA:
undetectable
5btaB-4kzkA:
3.6
5btaC-4kzkA:
undetectable
5btaA-4kzkA:
19.85
5btaB-4kzkA:
22.65
5btaC-4kzkA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
4 / 6 ARG A 244
GLY A 246
THR A 277
GLU A 247
None
0.95A 5btcA-4kzkA:
undetectable
5btcC-4kzkA:
undetectable
5btcD-4kzkA:
3.5
5btcA-4kzkA:
19.85
5btcC-4kzkA:
19.85
5btcD-4kzkA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
4 / 6 ARG A 244
GLY A 246
THR A 277
GLU A 247
None
0.90A 5btcA-4kzkA:
undetectable
5btcB-4kzkA:
3.5
5btcC-4kzkA:
undetectable
5btcA-4kzkA:
19.85
5btcB-4kzkA:
22.65
5btcC-4kzkA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
4 / 7 ARG A 244
GLY A 246
THR A 277
GLU A 247
None
0.89A 5btdA-4kzkA:
undetectable
5btdB-4kzkA:
4.0
5btdC-4kzkA:
undetectable
5btdA-4kzkA:
20.23
5btdB-4kzkA:
22.65
5btdC-4kzkA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
4 / 7 ARG A 244
GLY A 246
THR A 277
GLU A 247
None
0.92A 5btfA-4kzkA:
undetectable
5btfB-4kzkA:
4.1
5btfC-4kzkA:
undetectable
5btfA-4kzkA:
19.85
5btfB-4kzkA:
22.65
5btfC-4kzkA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
4 / 6 ALA A 202
ARG A 244
GLY A 246
GLU A 247
None
0.85A 5btgA-4kzkA:
undetectable
5btgB-4kzkA:
4.0
5btgC-4kzkA:
undetectable
5btgA-4kzkA:
20.23
5btgB-4kzkA:
22.65
5btgC-4kzkA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
4 / 6 ARG A 244
GLY A 246
THR A 277
GLU A 247
None
0.88A 5btgA-4kzkA:
undetectable
5btgB-4kzkA:
4.0
5btgC-4kzkA:
undetectable
5btgA-4kzkA:
20.23
5btgB-4kzkA:
22.65
5btgC-4kzkA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 9 LEU A 130
LEU A 100
GLY A 101
LEU A 122
ALA A  95
None
0.98A 5dqfA-4kzkA:
undetectable
5dqfA-4kzkA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 11 ALA A  54
GLU A  55
LEU A  65
ILE A 302
GLY A  90
None
1.21A 5dxbB-4kzkA:
undetectable
5dxbB-4kzkA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
3 / 3 ASP A  44
LEU A 333
ARG A 328
GAL  A 600 (-3.2A)
None
None
0.89A 5e8qA-4kzkA:
undetectable
5e8qA-4kzkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 12 PHE A 279
VAL A 243
ALA A 216
ALA A 242
GLY A 241
None
1.27A 5tzoA-4kzkA:
undetectable
5tzoA-4kzkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis)
5 / 12 PHE A 279
VAL A 243
ALA A 216
ALA A 242
GLY A 241
None
1.25A 5tzoC-4kzkA:
undetectable
5tzoC-4kzkA:
21.05