SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kzp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
6 / 11 GLY A  29
ALA A  31
ASP A  53
ASP A  80
ALA A 107
VAL A 129
GOL  A 407 (-3.3A)
None
GOL  A 407 (-3.1A)
EDO  A 401 (-3.1A)
GOL  A 407 (-3.8A)
None
0.49A 1uayA-4kzpA:
26.4
1uayA-4kzpA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
6 / 10 GLY A  29
ALA A  31
ASP A  53
ASP A  80
ALA A 107
VAL A 129
GOL  A 407 (-3.3A)
None
GOL  A 407 (-3.1A)
EDO  A 401 (-3.1A)
GOL  A 407 (-3.8A)
None
0.42A 1uayB-4kzpA:
27.1
1uayB-4kzpA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 ILE A  81
ALA A  55
ILE A  54
THR A  28
VAL A  26
None
1.38A 1vq1A-4kzpA:
3.1
1vq1A-4kzpA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 GLY A  29
ASP A  53
ASP A  80
ASN A 106
ALA A 107
GOL  A 407 (-3.3A)
GOL  A 407 (-3.1A)
EDO  A 401 (-3.1A)
GOL  A 407 ( 4.8A)
GOL  A 407 (-3.8A)
0.99A 2bm9E-4kzpA:
3.0
2bm9E-4kzpA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
4 / 6 SER A 250
PHE A 244
PHE A 258
ASN A 204
None
1.23A 3lskB-4kzpA:
3.8
3lskB-4kzpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
4 / 6 SER A 250
PHE A 244
PHE A 258
ASN A 204
None
1.19A 3lskD-4kzpA:
3.8
3lskD-4kzpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 VAL A  63
LEU A  64
VAL A  27
GLY A  29
LEU A  58
None
None
None
GOL  A 407 (-3.3A)
None
1.09A 3pghD-4kzpA:
undetectable
3pghD-4kzpA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 GLY A  98
ASP A 101
LYS A  73
ALA A  47
ALA A  43
None
0.96A 3sudA-4kzpA:
undetectable
3sudA-4kzpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 GLY A  98
ASP A 101
ILE A  67
ALA A  47
ALA A  43
None
0.95A 3sudC-4kzpA:
undetectable
3sudC-4kzpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 GLY A  98
ASP A 101
ILE A  67
ALA A  47
ALA A  43
None
0.98A 3sueA-4kzpA:
undetectable
3sueA-4kzpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 GLY A  98
ASP A 101
ILE A  67
ALA A  47
ALA A  43
None
0.97A 3sufD-4kzpA:
undetectable
3sufD-4kzpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 10 GLY A 108
ALA A 107
ILE A 185
LEU A 136
ILE A  81
GOL  A 407 (-3.4A)
GOL  A 407 (-3.8A)
None
None
None
0.93A 3ttpA-4kzpA:
undetectable
3ttpA-4kzpA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 10 GLY A 108
ALA A 107
ILE A 185
LEU A 136
ILE A  81
GOL  A 407 (-3.4A)
GOL  A 407 (-3.8A)
None
None
None
0.94A 3ttpB-4kzpA:
undetectable
3ttpB-4kzpA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 THR A 212
ALA A  30
GLY A  35
ALA A  37
ASP A 236
None
1.35A 5l5zH-4kzpA:
undetectable
5l5zI-4kzpA:
undetectable
5l5zH-4kzpA:
23.53
5l5zI-4kzpA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 THR A 212
ALA A  30
GLY A  35
ALA A  37
ASP A 236
None
1.35A 5l5zV-4kzpA:
undetectable
5l5zW-4kzpA:
undetectable
5l5zV-4kzpA:
23.53
5l5zW-4kzpA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
3 / 3 LYS A 182
HIS A 134
HIS A 130
None
1.07A 5oexA-4kzpA:
undetectable
5oexA-4kzpA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
3 / 3 LYS A 182
HIS A 134
HIS A 130
None
1.01A 5oexB-4kzpA:
undetectable
5oexB-4kzpA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
3 / 3 LYS A 182
HIS A 134
HIS A 130
None
1.01A 5oexC-4kzpA:
undetectable
5oexC-4kzpA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
3 / 3 LYS A 182
HIS A 134
HIS A 130
None
1.04A 5oexD-4kzpA:
undetectable
5oexD-4kzpA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 10 GLY A  29
GLY A  35
THR A  28
ASN A 105
ILE A  81
GOL  A 407 (-3.3A)
None
None
None
None
1.20A 6exiA-4kzpA:
8.5
6exiA-4kzpA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 10 GLY A  29
GLY A  35
THR A  28
ASN A 105
ILE A  81
GOL  A 407 (-3.3A)
None
None
None
None
1.18A 6exiB-4kzpA:
8.4
6exiB-4kzpA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacteriu
m
smegmatis)
5 / 12 GLY A  29
GLY A  35
THR A  28
ASN A 105
ILE A  81
GOL  A 407 (-3.3A)
None
None
None
None
1.22A 6exiC-4kzpA:
7.7
6exiD-4kzpA:
7.7
6exiC-4kzpA:
18.73
6exiD-4kzpA:
18.73