SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kzy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 4kzy 40S RIBOSOMAL
PROTEIN S2
(Oryctolagus
cuniculus) 		4 / 7 ALA C 224
THR C 225
ALA C 228
PRO C 195
 None
 0.70A 2ql8A-4kzyC:
undetectable
2ql8B-4kzyC:
undetectable		 2ql8A-4kzyC:
20.24
2ql8B-4kzyC:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 4kzy HUMAN INITIATION
FACTOR EIF1
(Homo
sapiens) 		4 / 8 ALA l 103
LEU l 102
GLN l  48
ILE l  35
 None
 0.91A 3cldB-4kzyl:
undetectable		 3cldB-4kzyl:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 4kzy 40S RIBOSOMAL
PROTEIN S2
(Oryctolagus
cuniculus) 		5 / 9 LEU C  92
THR C 225
ALA C 222
LEU C 218
VAL C 178
 None
 1.43A 3ozkA-4kzyC:
undetectable		 3ozkA-4kzyC:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 4kzy 40S RIBOSOMAL
PROTEIN S2
(Oryctolagus
cuniculus) 		3 / 3 TYR C  67
MET C 201
LEU C  87
 None
 0.88A 3vw1D-4kzyC:
undetectable		 3vw1D-4kzyC:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 4kzy 40S RIBOSOMAL
PROTEIN S2
(Oryctolagus
cuniculus) 		5 / 12 LEU C  83
GLY C  84
VAL C 148
ILE C 140
VAL C 113
 None
 1.32A 4okwA-4kzyC:
undetectable		 4okwA-4kzyC:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4kzy 40S RIBOSOMAL
PROTEIN S2
(Oryctolagus
cuniculus) 		4 / 6 TYR C  67
ASP C 117
HIS C 121
ILE C 115
 None
 1.10A 5ih0A-4kzyC:
undetectable		 5ih0A-4kzyC:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4kzy 40S RIBOSOMAL
PROTEIN S2
(Oryctolagus
cuniculus) 		3 / 3 SER C 210
ALA C 211
THR C 215
 U  i1150 ( 4.4A)
C  i   4 ( 3.4A)
U  i   5 ( 3.4A)
 0.69A 5n0xB-4kzyC:
undetectable		 5n0xB-4kzyC:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 4kzy 40S RIBOSOMAL
PROTEIN S2
(Oryctolagus
cuniculus) 		5 / 12 VAL C 176
PRO C 149
VAL C 165
PHE C 221
ILE C 204
 C  i  14 ( 4.9A)
None
None
U  i   5 ( 4.9A)
None
 1.40A 6becA-4kzyC:
undetectable
6becB-4kzyC:
undetectable
6becC-4kzyC:
undetectable		 6becA-4kzyC:
19.61
6becB-4kzyC:
19.61
6becC-4kzyC:
19.61