SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_A_SAMA301_1 (CEPHALOSPORIN HYDROXYLASE CMCI)	4l08	HYDROLASE, ISOCHORISMATASE FAMILY (Pseudomonas putida)	3 / 3	LYS B 4 ASP B 192 ASP B 198	None	1.10A	2br4A-4l08B: 2.2	2br4A-4l08B: 22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF3_B_BO2B305_1 (PROTEASOME SUBUNIT BETA TYPE-6)	4l08	HYDROLASE, ISOCHORISMATASE FAMILY (Pseudomonas putida)	5 / 12	THR B 68 THR B 69 GLY B 143 THR B 51 SER B 121	None	1.32A	5lf3b-4l08B: undetectable	5lf3b-4l08B: 23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF3_N_BO2N304_1 (PROTEASOME SUBUNIT BETA TYPE-6)	4l08	HYDROLASE, ISOCHORISMATASE FAMILY (Pseudomonas putida)	5 / 12	THR B 68 THR B 69 GLY B 143 THR B 51 SER B 121	None	1.33A	5lf3N-4l08B: undetectable	5lf3N-4l08B: 23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4l08	HYDROLASE, ISOCHORISMATASE FAMILY (Pseudomonas putida)	5 / 12	TYR B 72 LEU B 83 SER B 120 ILE B 70 THR B 153	None	1.27A	6djzB-4l08B: undetectable	6djzB-4l08B: 25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EQP_A_BUWA601_1 (CHOLINESTERASE)	4l08	HYDROLASE, ISOCHORISMATASE FAMILY (Pseudomonas putida)	4 / 8	GLY B 32 THR B 40 SER B 30 TYR B 72	None	1.12A	6eqpA-4l08B: undetectable	6eqpA-4l08B: 17.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2BR4_A_SAMA301_1","CEPHALOSPORIN HYDROXYLASE CMCI","4l08","HYDROLASE, ISOCHORISMATASE FAMILY","Pseudomonas putida",3,"LYS B   4;ASP B 192;ASP B 198","None","1.10A","2br4A-4l08B:2.2","2br4A-4l08B:22.00"],["5LF3_B_BO2B305_1","PROTEASOME SUBUNIT BETA TYPE-6","4l08","HYDROLASE, ISOCHORISMATASE FAMILY","Pseudomonas putida",5,"THR B  68;THR B  69;GLY B 143;THR B  51;SER B 121","None","1.32A","5lf3b-4l08B:undetectable","5lf3b-4l08B:23.48"],["5LF3_N_BO2N304_1","PROTEASOME SUBUNIT BETA TYPE-6","4l08","HYDROLASE, ISOCHORISMATASE FAMILY","Pseudomonas putida",5,"THR B  68;THR B  69;GLY B 143;THR B  51;SER B 121","None","1.33A","5lf3N-4l08B:undetectable","5lf3N-4l08B:23.48"],["6DJZ_B_GMJB301_0","SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1","4l08","HYDROLASE, ISOCHORISMATASE FAMILY","Pseudomonas putida",5,"TYR B  72;LEU B  83;SER B 120;ILE B  70;THR B 153","None","1.27A","6djzB-4l08B:undetectable","6djzB-4l08B:25.56"],["6EQP_A_BUWA601_1","CHOLINESTERASE","4l08","HYDROLASE, ISOCHORISMATASE FAMILY","Pseudomonas putida",4,"GLY B  32;THR B  40;SER B  30;TYR B  72","None","1.12A","6eqpA-4l08B:undetectable","6eqpA-4l08B:17.62"]]