SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l0c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		5 / 12 VAL A 212
GLU A 220
ILE A 221
LEU A 204
ILE A 213
 None
 0.87A 1d1gB-4l0cA:
undetectable		 1d1gB-4l0cA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		4 / 7 GLU A 211
LYS A 132
PRO A 130
ALA A 131
 None
 1.36A 2ejgA-4l0cA:
undetectable		 2ejgA-4l0cA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		5 / 11 LEU A  26
ALA A 100
ILE A 202
VAL A  88
VAL A  90
 None
 0.90A 2nnpB-4l0cA:
undetectable		 2nnpB-4l0cA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		5 / 12 GLY A  58
ASP A  55
ILE A  28
GLY A  30
ILE A  31
 None
None
None
ACY  A 301 (-3.6A)
None
 0.90A 2o4sA-4l0cA:
undetectable		 2o4sA-4l0cA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		4 / 7 PRO A  29
ALA A  35
LEU A  27
ALA A  42
 None
 1.07A 2vcvA-4l0cA:
undetectable		 2vcvA-4l0cA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		4 / 7 MET A   1
PHE A  18
ALA A  42
LEU A 166
 None
 0.94A 2wx2A-4l0cA:
undetectable		 2wx2A-4l0cA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		4 / 8 MET A   1
PHE A  18
ALA A  42
LEU A 166
 None
 1.02A 2wx2B-4l0cA:
undetectable		 2wx2B-4l0cA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		5 / 12 LEU A 195
ILE A 202
THR A 230
VAL A 206
PRO A 119
 None
 1.14A 3a51D-4l0cA:
undetectable		 3a51D-4l0cA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		4 / 8 MET A   1
PHE A  18
ALA A  42
LEU A 166
 None
 0.76A 3khmA-4l0cA:
undetectable		 3khmA-4l0cA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		5 / 12 LEU A  78
LEU A  71
SER A 108
GLY A  92
ALA A  97
 None
 1.02A 3kk6A-4l0cA:
undetectable		 3kk6A-4l0cA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		4 / 8 MET A   1
PHE A  18
ALA A  42
LEU A 166
 None
 0.94A 3l4dD-4l0cA:
undetectable		 3l4dD-4l0cA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		5 / 10 GLY A  58
ASP A  55
ILE A  28
GLY A  30
ILE A  31
 None
None
None
ACY  A 301 (-3.6A)
None
 0.96A 3lzvA-4l0cA:
undetectable		 3lzvA-4l0cA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		3 / 3 HIS A 238
HIS A  93
MET A 239
 None
None
ACY  A 301 (-3.3A)
 0.82A 3mihA-4l0cA:
undetectable		 3mihA-4l0cA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		5 / 10 ALA A 104
LEU A 114
ILE A 202
THR A 230
VAL A 206
 None
 1.22A 3r9cA-4l0cA:
undetectable		 3r9cA-4l0cA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		4 / 6 THR A 188
GLY A 123
ARG A 105
ILE A 191
 None
 1.01A 4acbC-4l0cA:
undetectable		 4acbC-4l0cA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		4 / 7 GLU A 220
ARG A  98
GLY A 123
ARG A 126
 None
 0.99A 4fgzA-4l0cA:
undetectable		 4fgzA-4l0cA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		4 / 6 GLY A 123
PRO A 120
HIS A 238
ARG A  98
 None
 1.01A 4lajA-4l0cA:
undetectable
4lajB-4l0cA:
undetectable		 4lajA-4l0cA:
20.05
4lajB-4l0cA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		4 / 5 VAL A  90
LEU A  78
ILE A  28
LEU A  27
 None
 0.77A 4mghA-4l0cA:
undetectable		 4mghA-4l0cA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		5 / 11 GLY A  58
ASP A  55
ILE A  28
GLY A  30
ILE A  31
 None
None
None
ACY  A 301 (-3.6A)
None
 0.99A 4njvC-4l0cA:
undetectable		 4njvC-4l0cA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		4 / 5 ARG A 102
GLN A 197
ILE A 191
ASP A 190
 None
 1.39A 4z4hA-4l0cA:
3.8		 4z4hA-4l0cA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		4 / 6 ARG A  57
GLY A  58
SER A  64
LEU A  67
 None
None
ACY  A 302 (-3.4A)
None
 1.28A 5bphA-4l0cA:
2.6		 5bphA-4l0cA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		5 / 9 ILE A  31
LEU A  71
GLY A 185
MET A  74
ALA A  73
 None
 1.16A 5x66C-4l0cA:
undetectable		 5x66C-4l0cA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		5 / 12 ILE A  31
LEU A  71
GLY A 185
MET A  74
ALA A  73
 None
 1.13A 5x66F-4l0cA:
undetectable		 5x66F-4l0cA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		5 / 12 LEU A 116
HIS A 192
LEU A 195
GLY A 185
LEU A  71
 None
 1.18A 6b0lB-4l0cA:
undetectable		 6b0lB-4l0cA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		5 / 12 ILE A 101
ASP A 190
LEU A 114
THR A 199
LEU A 200
 None
 1.17A 6b54A-4l0cA:
undetectable		 6b54A-4l0cA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 4l0c DEFORMYLASE
(Pseudomonas
putida) 		5 / 12 LEU A  26
ALA A 100
ILE A 202
VAL A  88
VAL A  90
 None
 0.94A 6dh0A-4l0cA:
undetectable		 6dh0A-4l0cA:
18.47