SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l0j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 4l0j DNA HELICASE I
(Escherichia
coli) 		4 / 7 LEU A 624
GLU A 716
LEU A 718
MET A 745
 None
 1.15A 1linA-4l0jA:
undetectable		 1linA-4l0jA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 4l0j DNA HELICASE I
(Escherichia
coli) 		5 / 12 VAL A 747
LEU A 727
LEU A 735
VAL A 737
LEU A 770
 None
 0.99A 4k13A-4l0jA:
undetectable		 4k13A-4l0jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4l0j DNA HELICASE I
(Escherichia
coli) 		3 / 5 GLY A 625
GLY A 715
GLU A 716
 None
 0.49A 4z2eA-4l0jA:
undetectable
4z2eD-4l0jA:
undetectable		 4z2eA-4l0jA:
20.20
4z2eD-4l0jA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4l0j DNA HELICASE I
(Escherichia
coli) 		4 / 8 LEU A 704
MET A 654
LEU A 681
ILE A 695
 None
 0.98A 5mzjA-4l0jA:
undetectable		 5mzjA-4l0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4l0j DNA HELICASE I
(Escherichia
coli) 		5 / 9 PRO A 755
GLY A 751
LEU A 735
ARG A 734
GLN A 736
 None
 1.36A 5o96E-4l0jA:
undetectable
5o96F-4l0jA:
undetectable		 5o96E-4l0jA:
23.22
5o96F-4l0jA:
23.22