SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l15'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4l15 FIDGETIN-LIKE
PROTEIN 1
(Caenorhabditis
elegans) 		6 / 12 ILE A 365
ILE A 331
LEU A 587
PRO A 588
LEU A 321
ILE A 480
 None
 1.50A 1df7A-4l15A:
undetectable		 1df7A-4l15A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4l15 FIDGETIN-LIKE
PROTEIN 1
(Caenorhabditis
elegans) 		3 / 3 SER A 487
GLU A 486
GLU A 484
 None
 0.66A 1eqbD-4l15A:
undetectable		 1eqbD-4l15A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4l15 FIDGETIN-LIKE
PROTEIN 1
(Caenorhabditis
elegans) 		3 / 3 SER A 487
GLU A 486
GLU A 484
 None
 0.66A 1eqbB-4l15A:
undetectable		 1eqbB-4l15A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4l15 FIDGETIN-LIKE
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 10 ASP A 418
LEU A 421
ILE A 435
PHE A 413
ILE A 380
 None
 1.08A 1i18A-4l15A:
undetectable
1i18B-4l15A:
undetectable		 1i18A-4l15A:
14.15
1i18B-4l15A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4l15 FIDGETIN-LIKE
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 5 LEU A 457
VAL A 369
CYH A 368
ALA A 316
 None
 1.00A 1mz9D-4l15A:
undetectable		 1mz9D-4l15A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4l15 FIDGETIN-LIKE
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 4 LEU A 457
VAL A 369
CYH A 368
ALA A 316
 None
 0.95A 1mz9E-4l15A:
undetectable		 1mz9E-4l15A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4l15 FIDGETIN-LIKE
PROTEIN 1
(Caenorhabditis
elegans) 		3 / 3 ARG A 471
ARG A 477
ILE A 417
 None
 0.81A 1uobA-4l15A:
undetectable		 1uobA-4l15A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 4l15 FIDGETIN-LIKE
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 LEU A 400
PHE A 401
ILE A 414
ALA A 382
THR A 386
 None
 1.15A 2v0mC-4l15A:
undetectable		 2v0mC-4l15A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4l15 FIDGETIN-LIKE
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 7 MET A 307
PHE A 378
ALA A 404
THR A 290
 None
 0.96A 2wx2A-4l15A:
undetectable		 2wx2A-4l15A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 4l15 FIDGETIN-LIKE
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 8 MET A 307
PHE A 378
ALA A 404
THR A 290
 None
 0.86A 3khmA-4l15A:
undetectable		 3khmA-4l15A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4l15 FIDGETIN-LIKE
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 8 MET A 307
PHE A 378
ALA A 404
THR A 290
 None
 0.87A 3l4dD-4l15A:
undetectable		 3l4dD-4l15A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4l15 FIDGETIN-LIKE
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 ILE A 306
LEU A 400
ALA A 382
THR A 386
VAL A 397
 None
 1.06A 3rukA-4l15A:
undetectable		 3rukA-4l15A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4l15 FIDGETIN-LIKE
PROTEIN 1
(Caenorhabditis
elegans) 		3 / 3 THR A 437
VAL A 441
GLU A 394
 None
 0.59A 3v4tA-4l15A:
undetectable
3v4tD-4l15A:
1.1		 3v4tA-4l15A:
24.48
3v4tD-4l15A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 4l15 FIDGETIN-LIKE
PROTEIN 1
(Caenorhabditis
elegans) 		3 / 3 PRO A 357
LEU A 321
SER A 519
 None
 0.70A 5fsaB-4l15A:
undetectable		 5fsaB-4l15A:
20.95