SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l1f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		3 / 3 LEU A  24
SER A  77
ASN A 355
 None
 0.74A 1bx4A-4l1fA:
undetectable		 1bx4A-4l1fA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		4 / 6 LEU A 111
ILE A  98
MET A 100
VAL A 299
 None
 1.02A 2ygoA-4l1fA:
undetectable		 2ygoA-4l1fA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		3 / 3 GLY A  49
GLY A 117
GLY A  46
 None
 0.40A 3bogC-4l1fA:
undetectable		 3bogC-4l1fA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		5 / 12 GLU A 230
ILE A 234
GLY A 102
PHE A 101
TYR A 110
 None
 1.18A 3nrrA-4l1fA:
undetectable		 3nrrA-4l1fA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		5 / 12 GLU A 230
ILE A 234
GLY A 102
PHE A 101
TYR A 110
 None
 1.21A 3nrrB-4l1fA:
undetectable		 3nrrB-4l1fA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		4 / 7 THR A 238
GLY A 241
GLY A 364
THR A 365
 None
None
COS  A 402 (-3.1A)
FAD  A 401 (-2.7A)
 0.80A 3tajA-4l1fA:
undetectable		 3tajA-4l1fA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		4 / 8 TYR A  59
THR A 103
TYR A  99
LEU A 225
 None
 0.94A 3wipG-4l1fA:
undetectable
3wipH-4l1fA:
undetectable		 3wipG-4l1fA:
16.88
3wipH-4l1fA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		5 / 12 LEU A 212
ALA A 122
GLU A 199
ALA A 210
THR A 209
 None
None
None
None
FAD  A 401 ( 3.9A)
 1.28A 4fiaA-4l1fA:
undetectable		 4fiaA-4l1fA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		5 / 12 LEU A 212
ALA A 122
GLU A 199
ALA A 210
THR A 209
 None
None
None
None
FAD  A 401 ( 3.9A)
 1.28A 4fiaA-4l1fA:
undetectable		 4fiaA-4l1fA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		5 / 12 GLU A 230
ILE A 234
GLY A 102
PHE A 101
TYR A 110
 None
 1.24A 4foxE-4l1fA:
undetectable		 4foxE-4l1fA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		4 / 6 ALA A 302
LEU A 305
ASP A 240
GLU A 237
 None
None
COS  A 402 (-2.9A)
COS  A 402 (-4.5A)
 0.88A 4g24A-4l1fA:
undetectable		 4g24A-4l1fA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		4 / 5 ILE A 292
ASP A  81
GLU A 255
VAL A 299
 None
 1.24A 4nkxC-4l1fA:
undetectable		 4nkxC-4l1fA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		4 / 5 ILE A 292
ASP A  81
GLU A 255
VAL A 299
 None
 1.23A 4nkxD-4l1fA:
undetectable		 4nkxD-4l1fA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		5 / 11 GLY A 204
GLY A 203
ILE A 358
GLY A  84
ILE A 253
 None
None
FAD  A 401 (-4.6A)
None
None
 1.05A 4qoiA-4l1fA:
undetectable
4qoiB-4l1fA:
undetectable		 4qoiA-4l1fA:
21.08
4qoiB-4l1fA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		4 / 7 ALA A 122
ALA A 210
GLU A 199
SER A 207
 None
 0.80A 4r1zB-4l1fA:
0.8		 4r1zB-4l1fA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		5 / 12 GLY A  82
ILE A 208
THR A  86
ILE A  42
GLY A 245
 None
 0.94A 5d4uC-4l1fA:
undetectable		 5d4uC-4l1fA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		3 / 3 THR A 158
ALA A  89
ASN A 159
 FAD  A 401 (-3.9A)
None
None
 0.34A 5ersA-4l1fA:
undetectable		 5ersA-4l1fA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		4 / 6 HIS A 301
MET A   1
ASN A 307
GLN A   9
 None
 1.16A 5xdhA-4l1fA:
undetectable
5xdhC-4l1fA:
undetectable		 5xdhA-4l1fA:
12.37
5xdhC-4l1fA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		4 / 6 GLN A   9
HIS A 301
MET A   1
ASN A 307
 None
 1.21A 5xdhA-4l1fA:
undetectable
5xdhC-4l1fA:
undetectable		 5xdhA-4l1fA:
12.37
5xdhC-4l1fA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		5 / 12 LYS A  13
LEU A  71
LEU A 251
ILE A 292
ALA A 295
 None
 1.15A 5xprA-4l1fA:
0.0		 5xprA-4l1fA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		4 / 7 VAL A 168
PRO A  97
ILE A 157
THR A 126
 None
None
FAD  A 401 (-4.3A)
FAD  A 401 ( 3.3A)
 0.98A 6cduF-4l1fA:
2.4
6cduG-4l1fA:
3.2		 6cduF-4l1fA:
20.15
6cduG-4l1fA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		5 / 10 THR A 139
CYH A 217
VAL A 168
ALA A 170
LEU A 186
 None
 1.09A 6czmA-4l1fA:
undetectable
6czmC-4l1fA:
undetectable		 6czmA-4l1fA:
22.04
6czmC-4l1fA:
22.04