SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l1k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4l1k D-ALANINE--D-ALANINE
LIGASE
(Xanthomonas
oryzae) 		5 / 11 TYR A 339
GLU A 348
ILE A 347
LEU A  28
LEU A   8
 None
 1.28A 1mrqA-4l1kA:
undetectable		 1mrqA-4l1kA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4l1k D-ALANINE--D-ALANINE
LIGASE
(Xanthomonas
oryzae) 		4 / 4 ILE A 175
LEU A 174
VAL A 220
ALA A 187
 None
 0.94A 1mz9A-4l1kA:
undetectable		 1mz9A-4l1kA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4l1k D-ALANINE--D-ALANINE
LIGASE
(Xanthomonas
oryzae) 		4 / 5 ILE A 175
LEU A 174
VAL A 220
ALA A 187
 None
 0.83A 1mz9C-4l1kA:
undetectable		 1mz9C-4l1kA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 4l1k D-ALANINE--D-ALANINE
LIGASE
(Xanthomonas
oryzae) 		3 / 3 TYR A 290
TYR A 328
GLY A 235
 None
 0.74A 3eteB-4l1kA:
3.2
3eteD-4l1kA:
2.4
3eteF-4l1kA:
2.8		 3eteB-4l1kA:
19.54
3eteD-4l1kA:
19.54
3eteF-4l1kA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4l1k D-ALANINE--D-ALANINE
LIGASE
(Xanthomonas
oryzae) 		5 / 12 SER A  20
LEU A  21
ILE A  43
PHE A  57
LEU A 120
 None
 1.06A 3w67D-4l1kA:
undetectable		 3w67D-4l1kA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4l1k D-ALANINE--D-ALANINE
LIGASE
(Xanthomonas
oryzae) 		3 / 3 ASP A 142
LYS A 141
ASP A 140
 None
ANP  A 401 (-2.6A)
None
 0.79A 4a7tA-4l1kA:
undetectable		 4a7tA-4l1kA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4l1k D-ALANINE--D-ALANINE
LIGASE
(Xanthomonas
oryzae) 		5 / 12 ASN A 317
LEU A 342
GLY A 297
SER A 130
GLN A 117
 None
 1.26A 4djeA-4l1kA:
undetectable		 4djeA-4l1kA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4l1k D-ALANINE--D-ALANINE
LIGASE
(Xanthomonas
oryzae) 		5 / 12 LEU A  40
PHE A  57
GLY A  12
LEU A   8
ALA A  24
 None
 1.11A 5h5fA-4l1kA:
undetectable		 5h5fA-4l1kA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4l1k D-ALANINE--D-ALANINE
LIGASE
(Xanthomonas
oryzae) 		3 / 3 VAL A 316
GLN A 291
CYH A 295
 None
 0.68A 5icxA-4l1kA:
undetectable
5icxE-4l1kA:
undetectable		 5icxA-4l1kA:
19.79
5icxE-4l1kA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4l1k D-ALANINE--D-ALANINE
LIGASE
(Xanthomonas
oryzae) 		3 / 3 VAL A 316
GLN A 291
CYH A 295
 None
 0.65A 5icxC-4l1kA:
2.1
5icxF-4l1kA:
undetectable		 5icxC-4l1kA:
19.79
5icxF-4l1kA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4l1k D-ALANINE--D-ALANINE
LIGASE
(Xanthomonas
oryzae) 		4 / 5 PHE A 322
LEU A 234
GLY A 297
ILE A 105
 None
 0.93A 5ik1A-4l1kA:
undetectable		 5ik1A-4l1kA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4l1k D-ALANINE--D-ALANINE
LIGASE
(Xanthomonas
oryzae) 		5 / 12 ILE A   9
LEU A 119
VAL A  39
ALA A  82
GLY A  81
 None
 0.97A 5uxdB-4l1kA:
undetectable		 5uxdB-4l1kA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4l1k D-ALANINE--D-ALANINE
LIGASE
(Xanthomonas
oryzae) 		4 / 8 GLY A 134
CYH A 295
GLY A 294
ALA A 292
 None
 0.64A 5vw5A-4l1kA:
undetectable		 5vw5A-4l1kA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4l1k D-ALANINE--D-ALANINE
LIGASE
(Xanthomonas
oryzae) 		3 / 3 LEU A 182
VAL A 171
ASP A 172
 None
 0.45A 5x23A-4l1kA:
undetectable		 5x23A-4l1kA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4l1k D-ALANINE--D-ALANINE
LIGASE
(Xanthomonas
oryzae) 		5 / 12 HIS A  17
GLY A  75
VAL A  76
GLY A  12
GLY A  11
 None
 1.08A 6brdB-4l1kA:
undetectable		 6brdB-4l1kA:
11.62