SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l1m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		5 / 12 ILE A 670
VAL A 714
ALA A 499
GLY A 717
HIS A 501
 None
 0.95A 1nbiA-4l1mA:
undetectable		 1nbiA-4l1mA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		5 / 12 ILE A 670
VAL A 714
ALA A 499
GLY A 717
HIS A 501
 None
 0.95A 1nbiB-4l1mA:
undetectable		 1nbiB-4l1mA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		5 / 12 PHE A 463
SER A 479
THR A 481
TRP A 433
GLY A 447
 None
UNX  A 807 ( 3.1A)
None
None
None
 1.23A 2x2iA-4l1mA:
undetectable		 2x2iA-4l1mA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		4 / 5 LEU A 600
GLN A 625
THR A 621
THR A 647
 None
None
None
SO4  A 802 (-3.5A)
 0.99A 2zj0B-4l1mA:
undetectable		 2zj0B-4l1mA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		4 / 5 LEU A 600
GLN A 625
THR A 621
THR A 647
 None
None
None
SO4  A 802 (-3.5A)
 1.06A 2zj0C-4l1mA:
undetectable		 2zj0C-4l1mA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		4 / 4 LEU A 600
GLN A 625
THR A 621
THR A 647
 None
None
None
SO4  A 802 (-3.5A)
 0.94A 2zj0D-4l1mA:
undetectable		 2zj0D-4l1mA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		4 / 5 LEU A 600
GLN A 625
THR A 621
THR A 647
 None
None
None
SO4  A 802 (-3.5A)
 1.06A 3ce6B-4l1mA:
undetectable		 3ce6B-4l1mA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		3 / 3 TYR A 634
ASP A 631
ASP A 643
 None
 0.87A 3ou7B-4l1mA:
undetectable		 3ou7B-4l1mA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		5 / 12 GLY A 447
PHE A 774
ILE A 456
TYR A 473
ILE A 465
 None
 1.04A 3pwwA-4l1mA:
undetectable		 3pwwA-4l1mA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		4 / 5 PHE A 463
LEU A 482
GLY A 447
VAL A 453
 None
 1.08A 3wrkD-4l1mA:
undetectable		 3wrkD-4l1mA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		5 / 12 GLU A 424
ILE A 426
ASP A 759
GLY A 757
VAL A 730
 None
 1.23A 4foxD-4l1mA:
undetectable		 4foxD-4l1mA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		5 / 12 GLU A 424
ILE A 426
ASP A 759
GLY A 757
VAL A 730
 None
 1.25A 4fqsA-4l1mA:
undetectable		 4fqsA-4l1mA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		5 / 12 GLU A 424
ILE A 426
ASP A 759
GLY A 757
VAL A 730
 None
 1.23A 4fqsB-4l1mA:
undetectable		 4fqsB-4l1mA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		4 / 7 ASP A 743
THR A 744
PHE A 742
HIS A 741
 None
 1.48A 4o4dA-4l1mA:
undetectable		 4o4dA-4l1mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		4 / 5 SER A 563
ALA A 564
HIS A 506
LEU A 508
 None
 1.42A 5dzkb-4l1mA:
undetectable
5dzkp-4l1mA:
undetectable		 5dzkb-4l1mA:
19.74
5dzkp-4l1mA:
0.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		4 / 5 SER A 563
ALA A 564
HIS A 506
LEU A 508
 None
 1.49A 5dzkc-4l1mA:
undetectable
5dzkq-4l1mA:
undetectable		 5dzkc-4l1mA:
19.74
5dzkq-4l1mA:
0.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		4 / 6 ILE A 456
GLY A 470
ASN A 469
ILE A 498
 None
 1.00A 5j4nB-4l1mA:
undetectable		 5j4nB-4l1mA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		4 / 4 LEU A 583
GLY A 578
SER A 588
SER A 587
 None
 1.32A 5uunA-4l1mA:
undetectable		 5uunA-4l1mA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		5 / 12 ILE A 766
VAL A 553
VAL A 608
ALA A 715
LEU A 510
 None
 1.15A 6a7pB-4l1mA:
undetectable		 6a7pB-4l1mA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens) 		5 / 12 ILE A 465
GLY A 470
ASN A 469
ILE A 498
ALA A 509
 None
 1.17A 6qxsD-4l1mA:
undetectable		 6qxsD-4l1mA:
20.77