SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l1y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		4 / 6 LEU A  86
ALA A  41
SER A  13
THR A  11
 None
 0.92A 1ictB-4l1yA:
undetectable		 1ictB-4l1yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		4 / 7 LEU A  86
SER A  13
THR A  11
VAL A   9
 None
 0.76A 1ictD-4l1yA:
undetectable		 1ictD-4l1yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		5 / 11 ALA A 276
GLU A 215
LEU A 246
LYS A 248
THR A  11
 None
 0.91A 1jomA-4l1yA:
undetectable		 1jomA-4l1yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		4 / 7 LEU A  86
ALA A  41
SER A  13
VAL A   9
 None
 0.80A 1tyrB-4l1yA:
undetectable		 1tyrB-4l1yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		5 / 11 THR A 219
ALA A 276
ILE A 169
PRO A 216
PHE A 278
 None
 1.34A 2admA-4l1yA:
undetectable		 2admA-4l1yA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		6 / 11 VAL A 218
THR A 219
ALA A 276
ILE A 169
PRO A 216
PHE A 278
 None
 1.36A 2admB-4l1yA:
undetectable		 2admB-4l1yA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		4 / 5 PHE A 167
PHE A 131
PHE A 122
VAL A 280
 None
 1.16A 2lh6A-4l1yA:
undetectable		 2lh6A-4l1yA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		3 / 3 LYS A  62
ARG A  20
VAL A  21
 None
None
HEM  A 300 (-4.1A)
 1.07A 2r2vC-4l1yA:
undetectable
2r2vD-4l1yA:
undetectable		 2r2vC-4l1yA:
9.50
2r2vD-4l1yA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		5 / 12 SER A 157
THR A  11
PHE A 278
ILE A 255
PHE A 167
 None
 1.43A 2vdyA-4l1yA:
undetectable		 2vdyA-4l1yA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		5 / 12 VAL A  44
VAL A  42
PHE A  49
PHE A  64
ASN A  78
 None
None
HEM  A 300 (-4.7A)
HEM  A 300 (-3.5A)
HEM  A 300 (-3.6A)
 1.21A 2y04B-4l1yA:
undetectable		 2y04B-4l1yA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		4 / 6 ALA A  41
SER A  13
THR A  11
VAL A   9
 None
 0.47A 3d2tB-4l1yA:
undetectable		 3d2tB-4l1yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		3 / 3 ARG A 153
ASP A 140
GLN A  45
 None
 0.84A 3lcvB-4l1yA:
undetectable		 3lcvB-4l1yA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		4 / 7 LEU A  86
ALA A  41
THR A  11
VAL A   9
 None
 0.72A 3ozkB-4l1yA:
undetectable		 3ozkB-4l1yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		4 / 6 ASP A 151
GLY A 117
VAL A 107
THR A 132
 None
 1.05A 3vqrA-4l1yA:
undetectable		 3vqrA-4l1yA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		4 / 5 ASP A 151
GLY A 117
VAL A 107
THR A 132
 None
 1.06A 3vqrB-4l1yA:
undetectable		 3vqrB-4l1yA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		5 / 12 SER A 157
THR A  11
PHE A 278
ILE A 255
PHE A 167
 None
 1.43A 4c49B-4l1yA:
undetectable		 4c49B-4l1yA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		5 / 12 SER A 157
THR A  11
PHE A 278
ILE A 255
PHE A 167
 None
 1.37A 4c49C-4l1yA:
undetectable		 4c49C-4l1yA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		5 / 12 SER A 157
THR A  11
PHE A 278
ILE A 255
PHE A 167
 None
 1.35A 4c49D-4l1yA:
undetectable		 4c49D-4l1yA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		4 / 8 ASN A  15
GLY A 170
THR A 133
GLY A 116
 None
 0.82A 4fo4B-4l1yA:
undetectable		 4fo4B-4l1yA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		4 / 6 LEU A  86
ALA A  41
SER A  13
THR A  11
 None
 0.75A 4i89A-4l1yA:
undetectable		 4i89A-4l1yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		4 / 7 LEU A  86
ALA A  41
THR A  11
VAL A   9
 None
 0.75A 4ik7A-4l1yA:
undetectable		 4ik7A-4l1yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		4 / 8 LEU A  86
ALA A  41
THR A  11
VAL A   9
 None
 0.74A 4ik7B-4l1yA:
undetectable		 4ik7B-4l1yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		4 / 4 LEU A 275
ILE A  40
HIS A  10
VAL A  12
 None
 1.09A 4xyzA-4l1yA:
undetectable		 4xyzA-4l1yA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		4 / 6 LEU A  86
ALA A  41
SER A  13
THR A  11
 None
 0.75A 5bojA-4l1yA:
undetectable		 5bojA-4l1yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4l1y SALIVARY NITROPHORIN
(Cimex
lectularius) 		4 / 6 LEU A  86
ALA A  41
SER A  13
THR A  11
 None
 0.71A 5l4iA-4l1yA:
undetectable		 5l4iA-4l1yA:
20.36