SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 12 VAL A 580
ALA A 587
LEU A 478
ILE A 532
ILE A 484
 None
 0.89A 1fk6A-4l22A:
undetectable		 1fk6A-4l22A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 11 SER A 743
ALA A 738
LEU A 428
ALA A 429
LEU A 447
 None
 1.06A 1jinA-4l22A:
undetectable		 1jinA-4l22A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 12 ALA A 738
LEU A 450
LEU A 428
ALA A 429
LEU A 447
 None
 0.89A 1jipA-4l22A:
undetectable		 1jipA-4l22A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 10 LEU A  69
VAL A  92
TYR A  29
TRP A 158
TYR A  75
 None
 1.30A 1lw0A-4l22A:
1.6		 1lw0A-4l22A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		3 / 3 GLU A 582
TRP A 420
LYS A   6
 None
 1.40A 1qu2A-4l22A:
undetectable		 1qu2A-4l22A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 9 LEU A  69
VAL A  92
TYR A  29
TRP A 158
TYR A  75
 None
 1.30A 1vrtA-4l22A:
1.7		 1vrtA-4l22A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 5 ALA A 110
PHE A  59
ASN A 278
ILE A  55
 None
 1.10A 1yc2D-4l22A:
4.9		 1yc2D-4l22A:
16.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_A_ACRA992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		8 / 10 ASN A 103
LEU A 106
TYR A 228
ARG A 240
ASP A 279
HIS A 281
HIS A 500
ALA A 538
 None
 0.71A 2ecpA-4l22A:
49.7		 2ecpA-4l22A:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_A_ACRA992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		8 / 10 ASN A 103
LEU A 106
TYR A 228
ASP A 231
ARG A 240
ASP A 279
HIS A 281
ALA A 538
 None
 0.81A 2ecpA-4l22A:
49.7		 2ecpA-4l22A:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_A_ACRA992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		8 / 10 ASN A 103
LEU A 106
TYR A 228
ASP A 279
HIS A 281
ARG A 498
HIS A 500
ALA A 538
 None
 0.75A 2ecpA-4l22A:
49.7		 2ecpA-4l22A:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_B_ACRB992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		9 / 10 ASN A 103
LEU A 106
TYR A 228
ARG A 240
ASP A 279
HIS A 281
ARG A 498
HIS A 500
ALA A 538
 None
 0.72A 2ecpB-4l22A:
48.5		 2ecpB-4l22A:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_B_ACRB992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		8 / 10 ASN A 103
LEU A 106
TYR A 228
ASP A 231
ARG A 240
ASP A 279
HIS A 281
ALA A 538
 None
 0.79A 2ecpB-4l22A:
48.5		 2ecpB-4l22A:
39.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 10 LEU A  69
VAL A  92
TYR A  29
TRP A 158
TYR A  75
 None
 1.38A 2hndA-4l22A:
undetectable		 2hndA-4l22A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 10 LEU A  69
VAL A  92
TYR A  29
TRP A 158
TYR A  75
 None
 1.36A 2hnyA-4l22A:
undetectable		 2hnyA-4l22A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 5 LEU A 339
LEU A 332
LEU A 238
MET A 284
 None
 1.07A 2oaxF-4l22A:
undetectable		 2oaxF-4l22A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 11 SER A 490
LEU A 478
ILE A 492
ALA A 587
LEU A 472
 None
 1.32A 2v0mD-4l22A:
undetectable		 2v0mD-4l22A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		3 / 3 SER A 380
HIS A 372
ASP A 356
 None
 0.48A 2wa2B-4l22A:
undetectable		 2wa2B-4l22A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 6 VAL A 384
ASP A 279
TYR A  54
ASN A 413
 None
 1.43A 2zs9A-4l22A:
undetectable		 2zs9A-4l22A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 8 GLU A 422
LEU A 441
ALA A 429
ALA A 430
 None
 0.98A 3ax9B-4l22A:
undetectable		 3ax9B-4l22A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_B_SALB104_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 9 VAL A 248
MET A 247
ILE A  55
TYR A  54
ILE A 277
 None
 1.45A 3hgxB-4l22A:
0.8		 3hgxB-4l22A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HTH_B_PRLB201_0
(EBRA REPRESSOR)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 9 VAL A 308
LEU A 266
GLU A 288
TYR A 166
ASP A 257
 None
 1.32A 3hthB-4l22A:
1.3		 3hthB-4l22A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		3 / 3 SER A 165
ASP A 167
ASP A 201
 None
 0.89A 3iv6A-4l22A:
undetectable		 3iv6A-4l22A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 8 ARG A 476
GLN A 426
ASN A 469
ASP A 427
 None
 1.30A 3n66B-4l22A:
0.7		 3n66B-4l22A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 10 LEU A  69
VAL A  92
TYR A  29
TRP A 158
TYR A  75
 None
 1.32A 3qipA-4l22A:
1.8		 3qipA-4l22A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 10 ASN A 612
PHE A 609
ALA A 614
THR A 616
ILE A 627
 None
 1.40A 3t3qB-4l22A:
undetectable		 3t3qB-4l22A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 10 ASN A 612
PHE A 609
ALA A 614
THR A 616
ILE A 627
 None
 1.38A 3t3qC-4l22A:
undetectable		 3t3qC-4l22A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 10 ASN A 612
PHE A 609
ALA A 614
THR A 616
ILE A 627
 None
 1.36A 3t3qD-4l22A:
undetectable		 3t3qD-4l22A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		3 / 3 LYS A  51
ARG A 181
LEU A 254
 None
 1.43A 3v4tE-4l22A:
undetectable		 3v4tE-4l22A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 8 ASN A 410
PHE A 408
VAL A 381
HIS A 388
ALA A 601
 None
 1.30A 4eyzA-4l22A:
undetectable		 4eyzA-4l22A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 8 ASN A 410
PHE A 408
VAL A 381
HIS A 388
ALA A 601
 None
 1.29A 4eyzB-4l22A:
undetectable		 4eyzB-4l22A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 10 ALA A 385
LEU A 387
GLU A 626
SER A 643
THR A 412
 None
 1.28A 4g8zX-4l22A:
undetectable		 4g8zX-4l22A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 9 ASN A 734
ILE A 638
GLY A 618
MET A 620
VAL A 631
 None
 1.08A 4nptA-4l22A:
undetectable		 4nptA-4l22A:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 5 ASN A 143
LEU A 552
HIS A 549
GLU A 556
 None
 1.33A 4p6sA-4l22A:
undetectable		 4p6sA-4l22A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 4 ASN A  67
VAL A 578
THR A 416
ILE A 415
 None
 0.93A 4retA-4l22A:
4.0		 4retA-4l22A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 4 ASN A  67
VAL A 578
THR A 416
ILE A 415
 None
 0.93A 4retC-4l22A:
2.7		 4retC-4l22A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 12 ASN A 316
GLU A 396
PRO A 399
ASP A 356
ILE A 375
 None
 1.37A 4uroA-4l22A:
undetectable		 4uroA-4l22A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		6 / 12 ASP A 257
LEU A 260
LEU A 266
LEU A 255
ILE A 256
MET A 311
 None
 1.43A 4x1fA-4l22A:
undetectable		 4x1fA-4l22A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		6 / 12 ASP A 257
LEU A 260
LEU A 266
LEU A 255
ILE A 256
MET A 311
 None
 1.46A 4x1gA-4l22A:
undetectable		 4x1gA-4l22A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 6 ILE A 319
HIS A 369
ILE A 375
VAL A 381
 None
 0.89A 4zj8A-4l22A:
18.5		 4zj8A-4l22A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 12 ALA A 110
GLY A 102
GLY A 107
GLY A 105
LEU A 101
 None
 0.92A 5c0oH-4l22A:
2.9		 5c0oH-4l22A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 4 LEU A 159
ILE A 153
PRO A  99
LEU A 101
 None
 1.12A 5eb3A-4l22A:
3.2		 5eb3A-4l22A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 12 GLN A 593
PHE A 609
VAL A 580
GLY A 534
LYS A 497
 None
 1.41A 5i8fA-4l22A:
undetectable		 5i8fA-4l22A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		3 / 3 TYR A 228
TYR A 314
SER A 283
 None
 0.98A 5iktB-4l22A:
undetectable		 5iktB-4l22A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 8 ASN A  67
GLU A  98
TRP A 158
TYR A  29
 None
 1.30A 5oh1C-4l22A:
undetectable		 5oh1C-4l22A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 10 GLY A 105
HIS A 317
VAL A 384
ASN A 413
GLY A 603
 None
 0.67A 5vncC-4l22A:
16.9		 5vncC-4l22A:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		6 / 10 GLY A 105
HIS A 317
VAL A 384
ASN A 413
LYS A 503
GLU A 600
 None
 0.87A 5vncC-4l22A:
16.9		 5vncC-4l22A:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 5 LYS A 497
GLN A 593
GLY A 739
ILE A 415
 None
 1.42A 6debB-4l22A:
3.7		 6debB-4l22A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 12 GLY A 104
GLY A 105
ASP A 279
ASN A 413
ARG A 498
 None
 0.92A 6gneA-4l22A:
23.3		 6gneA-4l22A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		6 / 12 GLY A 104
GLY A 105
VAL A 384
ASN A 413
ARG A 498
GLY A 603
 None
 0.87A 6gneA-4l22A:
23.3		 6gneA-4l22A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		6 / 12 GLU A  58
GLY A 104
GLY A 105
ASP A 279
ASN A 413
ARG A 498
 None
 0.88A 6gneB-4l22A:
23.1		 6gneB-4l22A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		7 / 12 GLU A  58
GLY A 104
GLY A 105
VAL A 384
ASN A 413
ARG A 498
GLY A 603
 None
 0.86A 6gneB-4l22A:
23.1		 6gneB-4l22A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 9 GLY A 104
GLY A 105
TYR A 228
HIS A 317
VAL A 384
 None
 0.82A 6gnfA-4l22A:
24.0		 6gnfA-4l22A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 10 GLY A 105
LEU A 106
TYR A 228
HIS A 317
VAL A 384
 None
 0.81A 6gnfC-4l22A:
24.1		 6gnfC-4l22A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 12 ASP A 279
HIS A 281
ASN A 413
ARG A 498
GLY A 603
 None
 0.82A 6gnfC-4l22A:
24.1		 6gnfC-4l22A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 12 GLY A 104
LEU A 106
ASP A 279
HIS A 281
ASN A 413
 None
 0.73A 6gngA-4l22A:
23.1		 6gngA-4l22A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		6 / 12 GLU A  58
GLY A 105
TYR A 228
HIS A 317
ARG A 498
GLU A 600
 None
 0.78A 6gngA-4l22A:
23.1		 6gngA-4l22A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		7 / 12 GLU A  58
GLY A 105
TYR A 228
HIS A 317
VAL A 384
ARG A 498
GLY A 603
 None
 0.89A 6gngA-4l22A:
23.1		 6gngA-4l22A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		6 / 12 GLU A  58
GLY A 104
GLY A 105
LEU A 106
HIS A 281
ARG A 498
 None
 0.67A 6gngB-4l22A:
23.1		 6gngB-4l22A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4l22 PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 8 ASP A 363
HIS A 369
ASP A 347
GLU A 344
 None
 1.17A 6mn4C-4l22A:
undetectable		 6mn4C-4l22A:
17.57