SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 ALA B 231
GLY B 263
ILE B 264
THR B 257
ILE B 122
 None
HEM  B 602 ( 4.0A)
None
PLP  B 601 (-3.3A)
None
 0.92A 1c6yB-4l27B:
undetectable		 1c6yB-4l27B:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 THR B 262
THR B 260
PRO B 229
 None
PLP  B 601 (-3.3A)
HEM  B 602 (-4.0A)
 0.88A 1fjaC-4l27B:
undetectable		 1fjaC-4l27B:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 THR B 262
THR B 260
PRO B 229
 None
PLP  B 601 (-3.3A)
HEM  B 602 (-4.0A)
 0.87A 1fjaD-4l27B:
undetectable		 1fjaD-4l27B:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 5 GLY B 256
ILE B 306
VAL B 118
SER B 254
 PLP  B 601 (-3.1A)
PLP  B 601 (-4.7A)
None
PLP  B 601 ( 3.9A)
 0.88A 1rs7A-4l27B:
undetectable		 1rs7A-4l27B:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 6 GLY B 256
ILE B 306
VAL B 118
SER B 254
 PLP  B 601 (-3.1A)
PLP  B 601 (-4.7A)
None
PLP  B 601 ( 3.9A)
 0.96A 1rs7B-4l27B:
undetectable		 1rs7B-4l27B:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 THR B 260
PRO B 229
THR B 262
 PLP  B 601 (-3.3A)
HEM  B 602 (-4.0A)
None
 0.88A 1unmF-4l27B:
undetectable		 1unmF-4l27B:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 ASP B 309
ARG B 196
ASP B  47
 None
 0.89A 1vptA-4l27B:
undetectable		 1vptA-4l27B:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 THR B 260
PRO B 229
THR B 262
 PLP  B 601 (-3.3A)
HEM  B 602 (-4.0A)
None
 0.77A 209dC-4l27B:
undetectable		 209dC-4l27B:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 THR B 262
THR B 260
PRO B 229
 None
PLP  B 601 (-3.3A)
HEM  B 602 (-4.0A)
 0.85A 209dC-4l27B:
undetectable		 209dC-4l27B:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 11 ASN B 380
GLY B 153
THR B 146
ILE B 167
LEU B 181
 None
 1.19A 3bexC-4l27B:
undetectable
3bexD-4l27B:
undetectable		 3bexC-4l27B:
17.80
3bexD-4l27B:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 11 LEU B 181
ASN B 380
GLY B 153
THR B 146
ILE B 167
 None
 1.19A 3bexE-4l27B:
undetectable
3bexF-4l27B:
undetectable		 3bexE-4l27B:
17.80
3bexF-4l27B:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 11 ASN B 380
GLY B 153
THR B 146
ILE B 167
LEU B 181
 None
 1.17A 3bf1E-4l27B:
undetectable
3bf1F-4l27B:
undetectable		 3bf1E-4l27B:
17.80
3bf1F-4l27B:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 9 LEU B 315
THR B 257
GLY B 305
THR B 353
ILE B 373
 None
PLP  B 601 (-3.3A)
PLP  B 601 ( 4.0A)
None
None
 1.36A 3jusB-4l27B:
undetectable		 3jusB-4l27B:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 11 VAL B  90
GLY B 347
TYR B 381
ASN B 380
ILE B 339
 None
 1.44A 3owxA-4l27B:
undetectable
3owxB-4l27B:
undetectable		 3owxA-4l27B:
17.88
3owxB-4l27B:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 ALA B 231
GLY B 263
ILE B 264
THR B 257
ILE B 122
 None
HEM  B 602 ( 4.0A)
None
PLP  B 601 (-3.3A)
None
 0.90A 3tkgC-4l27B:
undetectable		 3tkgC-4l27B:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 SER B 254
LEU B 374
VAL B 372
ALA B 335
CYH B 346
 PLP  B 601 ( 3.9A)
None
None
None
None
 1.35A 3u9fD-4l27B:
undetectable
3u9fE-4l27B:
undetectable		 3u9fD-4l27B:
16.33
3u9fE-4l27B:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 SER B 254
LEU B 374
VAL B 372
ALA B 335
CYH B 346
 PLP  B 601 ( 3.9A)
None
None
None
None
 1.48A 3u9fG-4l27B:
undetectable
3u9fH-4l27B:
undetectable		 3u9fG-4l27B:
16.33
3u9fH-4l27B:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 ASN B 149
ASP B 376
ASN B 380
 PLP  B 601 (-3.5A)
PLP  B 601 (-3.1A)
None
 0.80A 4agaA-4l27B:
undetectable		 4agaA-4l27B:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 5 GLY B 256
ILE B 306
VAL B 118
SER B 254
 PLP  B 601 (-3.1A)
PLP  B 601 (-4.7A)
None
PLP  B 601 ( 3.9A)
 1.09A 4d33B-4l27B:
undetectable		 4d33B-4l27B:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 6 GLY B 256
ILE B 306
VAL B 118
SER B 254
 PLP  B 601 (-3.1A)
PLP  B 601 (-4.7A)
None
PLP  B 601 ( 3.9A)
 1.05A 4d39B-4l27B:
undetectable		 4d39B-4l27B:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 6 GLY B 256
ILE B 306
VAL B 118
SER B 254
 PLP  B 601 (-3.1A)
PLP  B 601 (-4.7A)
None
PLP  B 601 ( 3.9A)
 0.91A 4kcnA-4l27B:
undetectable		 4kcnA-4l27B:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 7 THR B 150
ILE B 122
THR B 260
GLY B 258
 None
None
PLP  B 601 (-3.3A)
PLP  B 601 (-3.5A)
 0.95A 4l39B-4l27B:
undetectable		 4l39B-4l27B:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 ASN B 380
GLY B 153
THR B 146
ILE B 167
LEU B 181
 None
 1.13A 4o5fA-4l27B:
undetectable
4o5fB-4l27B:
undetectable		 4o5fA-4l27B:
20.22
4o5fB-4l27B:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 LEU B 181
ASN B 380
GLY B 153
THR B 146
ILE B 167
 None
 1.12A 4o5fA-4l27B:
1.0
4o5fB-4l27B:
undetectable		 4o5fA-4l27B:
20.22
4o5fB-4l27B:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 GLN B 222
LEU B 220
GLY B 153
ASN B 149
ALA B 155
 None
None
None
PLP  B 601 (-3.5A)
None
 1.38A 4pclB-4l27B:
2.6		 4pclB-4l27B:
18.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 7 PRO B 447
THR B 535
ILE B 537
ASP B 538
 None
 0.80A 4pcuA-4l27B:
58.0		 4pcuA-4l27B:
98.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 11 ALA B 446
PRO B 447
VAL B 533
ILE B 537
ASP B 538
 None
 0.91A 4uuuB-4l27B:
17.6		 4uuuB-4l27B:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 11 PRO B 447
VAL B 533
THR B 535
ILE B 537
ASP B 538
 None
 0.64A 4uuuB-4l27B:
17.6		 4uuuB-4l27B:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 11 SER B 420
LEU B 423
PHE B 443
ALA B 446
PRO B 447
 None
 0.97A 4uuuB-4l27B:
17.6		 4uuuB-4l27B:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 LEU B 181
ASN B 380
GLY B 153
THR B 146
ILE B 167
 None
 1.12A 5b8hA-4l27B:
1.1
5b8hB-4l27B:
undetectable		 5b8hA-4l27B:
21.72
5b8hB-4l27B:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 ASP B 120
ASN B 228
GLN B 222
 None
PLP  B 601 ( 4.9A)
None
 0.64A 5k7uA-4l27B:
undetectable		 5k7uA-4l27B:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 VAL B 533
ALA B 545
LEU B 503
LEU B 499
VAL B 414
 None
 1.15A 5tudA-4l27B:
undetectable		 5tudA-4l27B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 ALA B 158
LEU B 154
VAL B 314
LEU B 136
TYR B 163
 None
None
HEM  B 602 (-4.1A)
None
None
 1.12A 6djzC-4l27B:
undetectable		 6djzC-4l27B:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 6 ILE B 261
LEU B 287
VAL B 320
ARG B 317
 None
 1.17A 6f6jA-4l27B:
undetectable		 6f6jA-4l27B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4l27 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 8 VAL B 118
ASN B 113
GLN B 243
GLU B 239
 None
 1.10A 6hzpA-4l27B:
undetectable		 6hzpA-4l27B:
22.83