SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		4 / 8 THR A  15
TRP A  10
LEU A 217
MET A 213
 None
 1.40A 1uw6A-4l35A:
undetectable
1uw6B-4l35A:
undetectable		 1uw6A-4l35A:
21.34
1uw6B-4l35A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		4 / 8 THR A  15
TRP A  10
LEU A 217
MET A 213
 None
 1.42A 1uw6D-4l35A:
undetectable
1uw6E-4l35A:
undetectable		 1uw6D-4l35A:
21.34
1uw6E-4l35A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		4 / 8 THR A  15
TRP A  10
LEU A 217
MET A 213
 None
 1.42A 1uw6G-4l35A:
undetectable
1uw6H-4l35A:
undetectable		 1uw6G-4l35A:
21.34
1uw6H-4l35A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		4 / 8 THR A  15
TRP A  10
LEU A 217
MET A 213
 None
 1.41A 1uw6P-4l35A:
undetectable
1uw6Q-4l35A:
undetectable		 1uw6P-4l35A:
21.34
1uw6Q-4l35A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		4 / 8 TRP A  10
LEU A 217
MET A 213
THR A  15
 None
 1.40A 1uw6P-4l35A:
undetectable
1uw6T-4l35A:
undetectable		 1uw6P-4l35A:
21.34
1uw6T-4l35A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		4 / 8 TYR A  77
ARG A  80
ARG A  74
ARG A 138
 None
 1.46A 2vxaA-4l35A:
undetectable
2vxaC-4l35A:
undetectable
2vxaE-4l35A:
undetectable		 2vxaA-4l35A:
15.48
2vxaC-4l35A:
15.48
2vxaE-4l35A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		4 / 8 ARG A  74
TYR A  77
ARG A  80
ARG A 138
 None
 1.44A 2vxaB-4l35A:
undetectable
2vxaC-4l35A:
undetectable
2vxaG-4l35A:
undetectable		 2vxaB-4l35A:
15.48
2vxaC-4l35A:
15.48
2vxaG-4l35A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		4 / 8 ARG A  74
TYR A  77
ARG A  80
ARG A 138
 None
 1.46A 2vxaH-4l35A:
undetectable
2vxaI-4l35A:
undetectable
2vxaJ-4l35A:
undetectable		 2vxaH-4l35A:
15.48
2vxaI-4l35A:
15.48
2vxaJ-4l35A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		4 / 8 ARG A 138
TYR A  77
ARG A  80
ARG A  74
 None
 1.47A 2vxaD-4l35A:
undetectable
2vxaJ-4l35A:
undetectable
2vxaL-4l35A:
undetectable		 2vxaD-4l35A:
15.48
2vxaJ-4l35A:
15.48
2vxaL-4l35A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		4 / 8 ARG A 138
ARG A  74
TYR A  77
ARG A  80
 None
 1.46A 2vxaH-4l35A:
undetectable
2vxaJ-4l35A:
undetectable
2vxaK-4l35A:
undetectable		 2vxaH-4l35A:
15.48
2vxaJ-4l35A:
15.48
2vxaK-4l35A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		4 / 8 ARG A 138
ARG A  74
TYR A  77
ARG A  80
 None
 1.45A 2vxaA-4l35A:
undetectable
2vxaK-4l35A:
undetectable
2vxaL-4l35A:
undetectable		 2vxaA-4l35A:
15.48
2vxaK-4l35A:
15.48
2vxaL-4l35A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		3 / 3 TRP A 193
VAL A 188
TRP A 142
 RET  A 301 (-4.2A)
None
RET  A 301 (-4.5A)
 1.32A 2xdcC-4l35A:
undetectable
2xdcD-4l35A:
undetectable		 2xdcC-4l35A:
6.06
2xdcD-4l35A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		3 / 3 TRP A 193
VAL A 188
TRP A 142
 RET  A 301 (-4.2A)
None
RET  A 301 (-4.5A)
 1.35A 2y6nE-4l35A:
undetectable
2y6nF-4l35A:
undetectable		 2y6nE-4l35A:
6.06
2y6nF-4l35A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		5 / 10 LEU A 160
VAL A 164
VAL A 233
THR A 171
PHE A 223
 None
 1.48A 3tbgC-4l35A:
1.5		 3tbgC-4l35A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		4 / 5 LEU A 153
LEU A 187
THR A 146
TRP A 142
 None
None
RET  A 301 (-4.0A)
RET  A 301 (-4.5A)
 1.41A 4do3A-4l35A:
undetectable		 4do3A-4l35A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		4 / 6 GLU A 198
TYR A  77
ILE A 205
THR A 209
 None
 1.37A 4qwpA-4l35A:
undetectable		 4qwpA-4l35A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		4 / 5 GLU A 198
TYR A  77
ILE A 205
THR A 209
 None
 1.38A 4qwpB-4l35A:
1.0		 4qwpB-4l35A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		4 / 4 TYR A  41
GLY A 232
SER A 230
LEU A 234
 None
 1.31A 5bphC-4l35A:
undetectable		 5bphC-4l35A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		5 / 12 VAL A 185
LEU A 228
VAL A 221
GLY A 224
LEU A 181
 None
 1.36A 5iktB-4l35A:
undetectable		 5iktB-4l35A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		5 / 12 ALA A 101
TYR A  41
ILE A  26
GLY A  21
PHE A  40
 None
 1.36A 5jlcA-4l35A:
1.0		 5jlcA-4l35A:
20.94