SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4l3n S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		3 / 3 SER A 426
THR A 574
PHE A 446
 None
 0.64A 2x91A-4l3nA:
undetectable		 2x91A-4l3nA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4l3n S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 12 ILE A 480
PHE A 571
ILE A 433
LEU A 417
LEU A 414
 None
 1.02A 3s79A-4l3nA:
undetectable		 3s79A-4l3nA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4l3n S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		3 / 3 GLN A 576
THR A 477
ASN A 475
 None
 0.90A 3v4tE-4l3nA:
undetectable		 3v4tE-4l3nA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4l3n S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 12 VAL A 420
LEU A 388
LEU A 414
LYS A 413
ILE A 573
 None
None
None
NAG  A1001 (-2.9A)
None
 1.08A 4ky8A-4l3nA:
undetectable		 4ky8A-4l3nA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4l3n S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 12 VAL A 420
LEU A 388
LEU A 414
LYS A 413
ILE A 573
 None
None
None
NAG  A1001 (-2.9A)
None
 1.09A 4ky8D-4l3nA:
undetectable		 4ky8D-4l3nA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4l3n S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 12 VAL A 420
LEU A 388
LEU A 414
LYS A 413
ILE A 573
 None
None
None
NAG  A1001 (-2.9A)
None
 1.07A 4ky8E-4l3nA:
undetectable		 4ky8E-4l3nA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 4l3n S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 12 ILE A 480
PHE A 571
ILE A 433
LEU A 417
LEU A 414
 None
 1.02A 5jkvA-4l3nA:
undetectable		 5jkvA-4l3nA:
17.30