SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 4l3w LIPASE
(Rhizopus
microsporus) 		5 / 12 GLY A 182
TYR A 150
TYR A 127
PHE A 212
TYR A 215
 None
 1.19A 1maaC-4l3wA:
undetectable		 1maaC-4l3wA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 4l3w LIPASE
(Rhizopus
microsporus) 		5 / 11 ILE A  94
ARG A 108
VAL A 146
LEU A 185
ALA A 181
 None
 0.99A 1n4hA-4l3wA:
undetectable		 1n4hA-4l3wA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4l3w LIPASE
(Rhizopus
microsporus) 		3 / 3 ARG A 230
VAL A 227
TRP A 251
 EDO  A 305 (-4.0A)
None
None
 1.13A 1qw6A-4l3wA:
undetectable		 1qw6A-4l3wA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4l3w LIPASE
(Rhizopus
microsporus) 		3 / 3 ARG A 230
VAL A 227
TRP A 251
 EDO  A 305 (-4.0A)
None
None
 1.21A 1qwcA-4l3wA:
undetectable		 1qwcA-4l3wA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 4l3w LIPASE
(Rhizopus
microsporus) 		4 / 7 THR A 123
ALA A 137
SER A 142
VAL A 121
 None
 0.83A 1tyrB-4l3wA:
undetectable		 1tyrB-4l3wA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4l3w LIPASE
(Rhizopus
microsporus) 		3 / 3 ARG A 230
VAL A 227
TRP A 251
 EDO  A 305 (-4.0A)
None
None
 1.18A 1vagA-4l3wA:
undetectable		 1vagA-4l3wA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_2
(NEURAMINIDASE)		 4l3w LIPASE
(Rhizopus
microsporus) 		4 / 4 ASP A 231
TRP A 251
ILE A 275
ARG A 230
 None
None
None
EDO  A 305 (-4.0A)
 1.36A 2htqA-4l3wA:
undetectable		 2htqA-4l3wA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 4l3w LIPASE
(Rhizopus
microsporus) 		4 / 8 ALA A  36
VAL A 259
LEU A  44
THR A  45
 None
 0.89A 2it4A-4l3wA:
undetectable		 2it4A-4l3wA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4l3w LIPASE
(Rhizopus
microsporus) 		4 / 5 ALA A  54
ALA A 178
ALA A 181
VAL A 146
 None
 0.92A 2nyrB-4l3wA:
undetectable		 2nyrB-4l3wA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 4l3w LIPASE
(Rhizopus
microsporus) 		5 / 12 ARG A 206
GLU A 267
PHE A 223
ASN A 273
HIS A 235
 None
 1.11A 3bjmB-4l3wA:
4.8		 3bjmB-4l3wA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4l3w LIPASE
(Rhizopus
microsporus) 		5 / 12 GLY A 170
VAL A 202
SER A 250
ILE A 167
ILE A  41
 None
 1.04A 3frqB-4l3wA:
undetectable		 3frqB-4l3wA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4l3w LIPASE
(Rhizopus
microsporus) 		4 / 4 LEU A 173
GLY A 174
GLY A 109
THR A  90
 None
 0.82A 3si7A-4l3wA:
undetectable		 3si7A-4l3wA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4l3w LIPASE
(Rhizopus
microsporus) 		4 / 8 ALA A  99
THR A  53
VAL A  59
PHE A  93
 None
 0.80A 4ltwA-4l3wA:
undetectable		 4ltwA-4l3wA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4l3w LIPASE
(Rhizopus
microsporus) 		4 / 5 GLN A 100
THR A 102
HIS A 224
LEU A  44
 None
None
SO4  A 318 (-4.1A)
None
 1.27A 4lvcA-4l3wA:
undetectable		 4lvcA-4l3wA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4l3w LIPASE
(Rhizopus
microsporus) 		5 / 12 PHE A 107
VAL A 166
ALA A 181
ILE A 199
ILE A 167
 None
 0.98A 4xdrA-4l3wA:
undetectable		 4xdrA-4l3wA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4l3w LIPASE
(Rhizopus
microsporus) 		4 / 5 VAL A 121
ILE A 290
PRO A 205
THR A 106
 None
 1.18A 4ze1A-4l3wA:
undetectable		 4ze1A-4l3wA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l3w LIPASE
(Rhizopus
microsporus) 		3 / 3 ARG A 230
VAL A 227
TRP A 251
 EDO  A 305 (-4.0A)
None
None
 1.26A 5fvoA-4l3wA:
undetectable		 5fvoA-4l3wA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 4l3w LIPASE
(Rhizopus
microsporus) 		5 / 12 HIS A 284
GLY A 203
HIS A 171
VAL A  60
GLY A 175
 None
 1.04A 5hg0B-4l3wA:
undetectable		 5hg0B-4l3wA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4l3w LIPASE
(Rhizopus
microsporus) 		4 / 7 PHE A 113
GLY A 109
GLY A 174
HIS A 171
 None
 0.87A 5n9xA-4l3wA:
undetectable		 5n9xA-4l3wA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 4l3w LIPASE
(Rhizopus
microsporus) 		5 / 12 GLY A 175
ALA A 176
GLY A 182
LEU A 140
VAL A 207
 None
 1.01A 6dh0B-4l3wA:
undetectable		 6dh0B-4l3wA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 4l3w LIPASE
(Rhizopus
microsporus) 		4 / 5 GLY A 182
LEU A 179
TYR A 215
GLN A 187
 None
 1.27A 6ji6A-4l3wA:
undetectable		 6ji6A-4l3wA:
21.85