SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4l4i RYANODINE RECEPTOR 2
(Mus
musculus) 		5 / 12 TYR A 356
GLY A 286
GLY A 230
GLY A 231
LEU A  62
 None
 1.21A 1qzzA-4l4iA:
undetectable		 1qzzA-4l4iA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4l4i RYANODINE RECEPTOR 2
(Mus
musculus) 		5 / 6 VAL A 300
THR A 301
GLU A 492
LEU A 274
ARG A 272
 None
 1.47A 1s8fB-4l4iA:
undetectable		 1s8fB-4l4iA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4l4i RYANODINE RECEPTOR 2
(Mus
musculus) 		4 / 6 PHE A 145
ALA A 144
LEU A 143
SER A 136
 None
 0.98A 1sbrA-4l4iA:
undetectable
1sbrB-4l4iA:
undetectable		 1sbrA-4l4iA:
16.27
1sbrB-4l4iA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4l4i RYANODINE RECEPTOR 2
(Mus
musculus) 		5 / 12 LEU A 436
LEU A 447
GLY A 519
ALA A 515
ALA A 512
 None
 1.15A 2br4A-4l4iA:
undetectable		 2br4A-4l4iA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4l4i RYANODINE RECEPTOR 2
(Mus
musculus) 		5 / 12 LEU A 436
LEU A 447
GLY A 519
ALA A 515
ALA A 512
 None
 1.15A 2br4D-4l4iA:
undetectable		 2br4D-4l4iA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4l4i RYANODINE RECEPTOR 2
(Mus
musculus) 		5 / 12 LEU A 436
LEU A 447
GLY A 519
ALA A 515
ALA A 512
 None
 1.14A 2br4E-4l4iA:
undetectable		 2br4E-4l4iA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4l4i RYANODINE RECEPTOR 2
(Mus
musculus) 		3 / 3 ARG A 298
SER A  63
TYR A 305
 None
 1.03A 2q2hA-4l4iA:
undetectable
2q2hB-4l4iA:
undetectable		 2q2hA-4l4iA:
12.39
2q2hB-4l4iA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4l4i RYANODINE RECEPTOR 2
(Mus
musculus) 		5 / 12 VAL A 452
ASN A 427
ARG A 504
LEU A 497
LEU A 533
 None
 1.39A 4kuoA-4l4iA:
undetectable		 4kuoA-4l4iA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4l4i RYANODINE RECEPTOR 2
(Mus
musculus) 		4 / 5 ILE A 419
ARG A 414
ASP A 458
VAL A 498
 None
GOL  A 601 (-3.3A)
GOL  A 601 (-4.5A)
None
 1.21A 4nkxD-4l4iA:
undetectable		 4nkxD-4l4iA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4l4i RYANODINE RECEPTOR 2
(Mus
musculus) 		4 / 6 THR A 302
THR A 301
HIS A 261
LEU A 316
 None
 1.07A 4pgfA-4l4iA:
undetectable		 4pgfA-4l4iA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4l4i RYANODINE RECEPTOR 2
(Mus
musculus) 		4 / 6 CYH A  47
LEU A  37
HIS A 193
LEU A 192
 None
 0.88A 5hpuC-4l4iA:
undetectable
5hpuD-4l4iA:
undetectable		 5hpuC-4l4iA:
2.95
5hpuD-4l4iA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4l4i RYANODINE RECEPTOR 2
(Mus
musculus) 		4 / 8 GLN A 225
ILE A 229
ASP A 232
GLY A 226
 None
 1.01A 5hwaA-4l4iA:
undetectable		 5hwaA-4l4iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4l4i RYANODINE RECEPTOR 2
(Mus
musculus) 		5 / 10 ALA A 215
VAL A  20
ILE A 119
ILE A 162
VAL A 175
 None
 1.22A 5nukA-4l4iA:
undetectable		 5nukA-4l4iA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 4l4i RYANODINE RECEPTOR 2
(Mus
musculus) 		5 / 12 LEU A 228
LEU A 277
LEU A 297
ILE A 363
ALA A 330
 None
 1.15A 5v0vA-4l4iA:
2.1		 5v0vA-4l4iA:
22.45