SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l4q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 9 LEU A 327
ASP A 331
ILE A 346
THR A 391
ILE A 390
 None
 1.20A 1hzeA-4l4qA:
undetectable
1hzeB-4l4qA:
undetectable		 1hzeA-4l4qA:
12.10
1hzeB-4l4qA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 9 THR A 391
ILE A 390
LEU A 327
ASP A 331
ILE A 346
 None
 1.19A 1hzeA-4l4qA:
undetectable
1hzeB-4l4qA:
undetectable		 1hzeA-4l4qA:
12.10
1hzeB-4l4qA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A  40
ALA A  42
ALA A 122
ASP A  39
ILE A  37
 None
 1.16A 1nt2A-4l4qA:
undetectable		 1nt2A-4l4qA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 6 GLY A 139
GLN A 140
VAL A 107
ALA A  96
 None
 0.90A 1p6kA-4l4qA:
undetectable		 1p6kA-4l4qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.85A 1p7lC-4l4qA:
27.9		 1p7lC-4l4qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.48A 1p7lC-4l4qA:
27.9		 1p7lC-4l4qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.84A 1p7lD-4l4qA:
28.0		 1p7lD-4l4qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.46A 1p7lD-4l4qA:
28.0		 1p7lD-4l4qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.83A 1rg9A-4l4qA:
27.9		 1rg9A-4l4qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.47A 1rg9A-4l4qA:
27.9		 1rg9A-4l4qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.84A 1rg9B-4l4qA:
27.9		 1rg9B-4l4qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.42A 1rg9B-4l4qA:
27.9		 1rg9B-4l4qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.86A 1rg9C-4l4qA:
27.9		 1rg9C-4l4qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.42A 1rg9C-4l4qA:
27.9		 1rg9C-4l4qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.85A 1rg9D-4l4qA:
27.9		 1rg9D-4l4qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.39A 1rg9D-4l4qA:
27.9		 1rg9D-4l4qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 6 PRO A  34
GLY A  32
ILE A 202
GLY A  30
 None
 0.84A 1usqC-4l4qA:
undetectable		 1usqC-4l4qA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 6 PRO A  34
GLY A  32
ILE A 202
GLY A  30
 None
 0.80A 1usqE-4l4qA:
undetectable		 1usqE-4l4qA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 4 GLY A 245
SER A 249
ILE A 178
HIS A 250
 None
 1.31A 1yajJ-4l4qA:
undetectable		 1yajJ-4l4qA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 110
ALA A 114
LEU A  92
ILE A 138
ALA A  44
 None
 0.86A 2aclG-4l4qA:
undetectable		 2aclG-4l4qA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.87A 2obvA-4l4qA:
28.2		 2obvA-4l4qA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.52A 2obvA-4l4qA:
28.2		 2obvA-4l4qA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 5 ILE A 346
LEU A 324
ASP A 384
ALA A 360
 None
 0.96A 2opxA-4l4qA:
undetectable		 2opxA-4l4qA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.82A 2p02A-4l4qA:
28.1		 2p02A-4l4qA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.58A 2p02A-4l4qA:
28.1		 2p02A-4l4qA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 7 ASN A 294
LEU A 296
TYR A 169
VAL A  26
 None
 1.10A 2uz2A-4l4qA:
undetectable		 2uz2A-4l4qA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 5 VAL A  18
THR A 175
THR A  16
ARG A  15
 None
 1.19A 3bjwA-4l4qA:
undetectable		 3bjwA-4l4qA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 282
GLY A  72
SER A 278
THR A 277
LEU A 126
 None
 1.10A 3uboB-4l4qA:
undetectable		 3uboB-4l4qA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 9 LEU A  92
SER A 136
VAL A 107
LEU A  49
ALA A 114
 None
 1.50A 3uncA-4l4qA:
0.8		 3uncA-4l4qA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 282
GLY A  72
SER A 278
THR A 277
LEU A 126
 None
 1.09A 4e3aA-4l4qA:
undetectable		 4e3aA-4l4qA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 11 ILE A 202
ILE A 217
ALA A 238
ILE A 221
VAL A 198
 None
 1.11A 4h1nA-4l4qA:
undetectable		 4h1nA-4l4qA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		7 / 8 HIS A  33
PRO A  34
ASP A 201
ALA A 218
TYR A 271
SER A 278
ASP A 283
 None
 0.84A 4k0bB-4l4qA:
55.7		 4k0bB-4l4qA:
51.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		7 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
ALA A 218
TYR A 271
SER A 278
 None
 0.52A 4k0bB-4l4qA:
55.7		 4k0bB-4l4qA:
51.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 282
GLY A  72
SER A 278
THR A 277
LEU A 126
 None
 1.08A 4k8pA-4l4qA:
undetectable		 4k8pA-4l4qA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 282
GLY A  72
SER A 278
THR A 277
LEU A 126
 None
 1.08A 4k8pB-4l4qA:
undetectable		 4k8pB-4l4qA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 282
GLY A  72
SER A 278
THR A 277
LEU A 126
 None
 1.09A 4k8tA-4l4qA:
undetectable		 4k8tA-4l4qA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 282
GLY A  72
SER A 278
THR A 277
LEU A 126
 None
 1.10A 4k8tB-4l4qA:
undetectable		 4k8tB-4l4qA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 282
GLY A  72
SER A 278
THR A 277
LEU A 126
 None
 1.10A 4k93A-4l4qA:
undetectable		 4k93A-4l4qA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 282
GLY A  72
SER A 278
THR A 277
LEU A 126
 None
 1.09A 4k93B-4l4qA:
undetectable		 4k93B-4l4qA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 282
GLY A  72
SER A 278
THR A 277
LEU A 126
 None
 1.08A 4k9cB-4l4qA:
undetectable		 4k9cB-4l4qA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 282
GLY A  72
SER A 278
THR A 277
LEU A 126
 None
 1.09A 4k9iA-4l4qA:
undetectable		 4k9iA-4l4qA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 282
GLY A  72
SER A 278
THR A 277
LEU A 126
 None
 1.10A 4k9iB-4l4qA:
undetectable		 4k9iB-4l4qA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.88A 4kttA-4l4qA:
25.8		 4kttA-4l4qA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.42A 4kttA-4l4qA:
25.8		 4kttA-4l4qA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.87A 4kttC-4l4qA:
26.0		 4kttC-4l4qA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.42A 4kttC-4l4qA:
26.0		 4kttC-4l4qA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 HIS A  33
PRO A  34
ASP A 201
LYS A 203
ASP A 283
 None
 1.01A 4ktvA-4l4qA:
26.1
4ktvB-4l4qA:
28.2		 4ktvA-4l4qA:
25.06
4ktvB-4l4qA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_C_ADNC403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 11 HIS A  33
PRO A  34
ASP A 201
LYS A 203
ASP A 283
 None
 0.97A 4ktvC-4l4qA:
26.0
4ktvD-4l4qA:
27.9		 4ktvC-4l4qA:
25.06
4ktvD-4l4qA:
25.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  62
ARG A  95
ASP A 162
ASN A 312
 None
 1.01A 4l7iA-4l4qA:
55.8		 4l7iA-4l4qA:
51.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		7 / 8 HIS A  33
PRO A  34
ASP A 201
ALA A 218
TYR A 271
SER A 278
ASP A 283
 None
 0.82A 4l7iB-4l4qA:
55.6		 4l7iB-4l4qA:
51.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		7 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
ALA A 218
TYR A 271
SER A 278
 None
 0.48A 4l7iB-4l4qA:
55.6		 4l7iB-4l4qA:
51.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 282
GLY A  72
SER A 278
THR A 277
LEU A 126
 None
 1.09A 4lbxA-4l4qA:
undetectable		 4lbxA-4l4qA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 282
GLY A  72
SER A 278
THR A 277
LEU A 126
 None
 1.09A 4lbxB-4l4qA:
undetectable		 4lbxB-4l4qA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 282
GLY A  72
SER A 278
THR A 277
LEU A 126
 None
 1.10A 4lc4B-4l4qA:
undetectable		 4lc4B-4l4qA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.89A 4ndnA-4l4qA:
4.4		 4ndnA-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.51A 4ndnA-4l4qA:
4.4		 4ndnA-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 7 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.83A 4ndnC-4l4qA:
25.9		 4ndnC-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 7 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.50A 4ndnC-4l4qA:
25.9		 4ndnC-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 7 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.52A 4odjA-4l4qA:
28.4		 4odjA-4l4qA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 6 LEU A 172
GLU A 341
ILE A 178
HIS A 250
 None
 0.98A 4xi3C-4l4qA:
undetectable		 4xi3C-4l4qA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.86A 5a1iA-4l4qA:
28.3		 5a1iA-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.54A 5a1iA-4l4qA:
28.3		 5a1iA-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 7 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.86A 5a1iA-4l4qA:
28.3		 5a1iA-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 7 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.54A 5a1iA-4l4qA:
28.3		 5a1iA-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.58A 5t8sB-4l4qA:
28.3		 5t8sB-4l4qA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.84A 6fbnB-4l4qA:
25.4		 6fbnB-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.61A 6fbnB-4l4qA:
25.4		 6fbnB-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.53A 6fboA-4l4qA:
28.3		 6fboA-4l4qA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.87A 6fcbA-4l4qA:
28.3		 6fcbA-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.54A 6fcbA-4l4qA:
28.3		 6fcbA-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.51A 6fcdA-4l4qA:
28.3		 6fcdA-4l4qA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 7 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.88A 6g6rA-4l4qA:
28.4		 6g6rA-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 7 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.56A 6g6rA-4l4qA:
28.4		 6g6rA-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 4l4q S-ADENOSYLMETHIONINE
SYNTHASE
(Thermococcus
kodakarensis) 		4 / 8 ALA A 111
LEU A  49
ALA A  96
GLU A  98
 None
 0.64A 6mdqA-4l4qA:
undetectable		 6mdqA-4l4qA:
10.80