SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A  31
ALA A  13
GLN A  12
LEU A  16
LEU A 114
 None
 1.29A 1g5yB-4l4wA:
undetectable		 1g5yB-4l4wA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A  85
THR A 210
VAL A 198
 None
 1.01A 1hxbA-4l4wA:
undetectable		 1hxbA-4l4wA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A   8
LEU A 114
GLU A  51
MET A  55
 None
 1.21A 2kuhA-4l4wA:
undetectable		 2kuhA-4l4wA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		4 / 6 TRP A 264
GLU A 201
ALA A  99
ALA A  78
 None
 1.16A 2zgwB-4l4wA:
undetectable		 2zgwB-4l4wA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A  72
LEU A  20
ASN A  59
VAL A 115
LEU A   8
 None
 1.07A 3a51C-4l4wA:
undetectable		 3a51C-4l4wA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  16
GLY A  21
ALA A  22
VAL A  68
ILE A  72
 None
 0.99A 3cyxA-4l4wA:
undetectable		 3cyxA-4l4wA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		4 / 6 VAL A 115
VAL A 106
ILE A  72
ARG A  95
 None
 1.13A 3mssA-4l4wA:
undetectable		 3mssA-4l4wA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		4 / 6 VAL A 115
VAL A 106
ILE A  72
ARG A  95
 None
 1.14A 3mssC-4l4wA:
undetectable		 3mssC-4l4wA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  16
GLY A  21
ALA A  22
VAL A  68
ILE A  72
 None
 1.06A 3oxxC-4l4wA:
undetectable		 3oxxC-4l4wA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		4 / 6 VAL A 115
VAL A 106
ILE A  72
ARG A  95
 None
 1.06A 3pyyA-4l4wA:
undetectable		 3pyyA-4l4wA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  64
VAL A  58
GLN A  12
 None
 0.53A 5qgjA-4l4wA:
undetectable		 5qgjA-4l4wA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  64
VAL A  58
GLN A  12
 None
 0.58A 5qgmA-4l4wA:
undetectable		 5qgmA-4l4wA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  64
VAL A  58
GLN A  12
 None
 0.49A 5qgnA-4l4wA:
undetectable		 5qgnA-4l4wA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  64
VAL A  58
GLN A  12
 None
 0.58A 5qgyA-4l4wA:
undetectable		 5qgyA-4l4wA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  64
VAL A  58
GLN A  12
 None
 0.60A 5qgzA-4l4wA:
undetectable		 5qgzA-4l4wA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  64
VAL A  58
GLN A  12
 None
 0.59A 5qh0A-4l4wA:
undetectable		 5qh0A-4l4wA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  64
VAL A  58
GLN A  12
 None
 0.59A 5qh2A-4l4wA:
undetectable		 5qh2A-4l4wA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  64
VAL A  58
GLN A  12
 None
 0.59A 5qh3A-4l4wA:
undetectable		 5qh3A-4l4wA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  64
VAL A  58
GLN A  12
 None
 0.54A 5qh5A-4l4wA:
undetectable		 5qh5A-4l4wA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  64
VAL A  58
GLN A  12
 None
 0.57A 5qh6A-4l4wA:
undetectable		 5qh6A-4l4wA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  64
VAL A  58
GLN A  12
 None
 0.57A 5qh7A-4l4wA:
undetectable		 5qh7A-4l4wA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  64
VAL A  58
GLN A  12
 None
 0.65A 5qhaA-4l4wA:
undetectable		 5qhaA-4l4wA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4l4w ESPG3
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  64
VAL A  58
GLN A  12
 None
 0.58A 5qhhA-4l4wA:
undetectable		 5qhhA-4l4wA:
24.11