SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 9 CYH A 117
LEU A 164
ALA A 167
LEU A 168
LEU A 127
 None
 1.24A 1hwiA-4l4xA:
undetectable		 1hwiA-4l4xA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4l4x AMPHI
(Streptomyces
nodosus) 		4 / 4 ASP A  94
LEU A  85
LEU A 111
LEU A  86
 None
 1.34A 1u18A-4l4xA:
undetectable		 1u18A-4l4xA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 12 ALA A 318
SER A 309
LEU A 307
LEU A 348
HIS A 304
 None
NDP  A 601 (-2.4A)
None
None
None
 0.94A 1ya4A-4l4xA:
2.7		 1ya4A-4l4xA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 12 GLY A 284
ARG A 310
ARG A 311
ALA A 366
ALA A 388
 NDP  A 601 (-3.3A)
NDP  A 601 (-3.1A)
NDP  A 601 (-3.9A)
NDP  A 601 (-4.1A)
NDP  A 601 ( 3.9A)
 1.00A 2bm9E-4l4xA:
4.9		 2bm9E-4l4xA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 12 GLY A 284
ARG A 310
ASP A 338
ALA A 366
ALA A 388
 NDP  A 601 (-3.3A)
NDP  A 601 (-3.1A)
NDP  A 601 (-3.4A)
NDP  A 601 (-4.1A)
NDP  A 601 ( 3.9A)
 0.95A 2bm9E-4l4xA:
4.9		 2bm9E-4l4xA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 12 GLY A 284
ARG A 310
ARG A 311
ALA A 366
ALA A 388
 NDP  A 601 (-3.3A)
NDP  A 601 (-3.1A)
NDP  A 601 (-3.9A)
NDP  A 601 (-4.1A)
NDP  A 601 ( 3.9A)
 0.94A 2br4B-4l4xA:
5.2		 2br4B-4l4xA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 12 GLY A 284
ARG A 310
ASP A 338
ALA A 366
ALA A 388
 NDP  A 601 (-3.3A)
NDP  A 601 (-3.1A)
NDP  A 601 (-3.4A)
NDP  A 601 (-4.1A)
NDP  A 601 ( 3.9A)
 0.90A 2br4C-4l4xA:
2.3		 2br4C-4l4xA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 12 GLY A 284
ARG A 310
ARG A 311
ALA A 366
ALA A 388
 NDP  A 601 (-3.3A)
NDP  A 601 (-3.1A)
NDP  A 601 (-3.9A)
NDP  A 601 (-4.1A)
NDP  A 601 ( 3.9A)
 1.09A 2br4E-4l4xA:
2.4		 2br4E-4l4xA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 12 GLY A 284
ARG A 310
ARG A 311
ALA A 366
ALA A 388
 NDP  A 601 (-3.3A)
NDP  A 601 (-3.1A)
NDP  A 601 (-3.9A)
NDP  A 601 (-4.1A)
NDP  A 601 ( 3.9A)
 0.87A 2br4F-4l4xA:
2.3		 2br4F-4l4xA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 12 GLY A 284
ARG A 310
ASP A 338
ALA A 366
ALA A 388
 NDP  A 601 (-3.3A)
NDP  A 601 (-3.1A)
NDP  A 601 (-3.4A)
NDP  A 601 (-4.1A)
NDP  A 601 ( 3.9A)
 0.85A 2br4F-4l4xA:
2.3		 2br4F-4l4xA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 12 LEU A 156
VAL A 162
ALA A 163
LEU A 164
VAL A 201
 None
 1.10A 2c12C-4l4xA:
undetectable		 2c12C-4l4xA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 11 GLN A 166
VAL A 162
ALA A 163
LEU A 160
LEU A 379
 None
 1.34A 2c12F-4l4xA:
undetectable		 2c12F-4l4xA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 12 LEU A 410
PHE A 408
ILE A 339
PRO A 196
VAL A 193
 None
None
NDP  A 601 (-4.2A)
None
None
 1.25A 2po7B-4l4xA:
3.0		 2po7B-4l4xA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 12 ALA A 431
ALA A 184
THR A 181
VAL A 219
GLY A 218
 None
 1.29A 2ve3B-4l4xA:
undetectable		 2ve3B-4l4xA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 10 THR A 207
SER A 412
SER A 449
GLY A 203
ALA A 428
 None
 1.46A 2x2iB-4l4xA:
undetectable		 2x2iB-4l4xA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 4l4x AMPHI
(Streptomyces
nodosus) 		3 / 3 GLY A 473
TYR A 507
SER A 472
 None
 0.68A 2xatA-4l4xA:
undetectable		 2xatA-4l4xA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 4l4x AMPHI
(Streptomyces
nodosus) 		3 / 3 ARG A 215
VAL A 201
THR A 161
 None
 0.72A 3cyxA-4l4xA:
undetectable		 3cyxA-4l4xA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 4l4x AMPHI
(Streptomyces
nodosus) 		3 / 3 GLU A 303
GLY A 278
THR A 279
 None
 0.56A 3iazA-4l4xA:
undetectable		 3iazA-4l4xA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 12 GLN A 166
VAL A 158
LEU A 154
GLY A 203
ALA A 428
 None
 1.13A 3kk6A-4l4xA:
undetectable		 3kk6A-4l4xA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4l4x AMPHI
(Streptomyces
nodosus) 		4 / 8 LEU A 222
VAL A 237
LEU A 238
ALA A 100
 None
 0.92A 3uniB-4l4xA:
undetectable		 3uniB-4l4xA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 9 THR A 283
LEU A 400
LEU A 396
VAL A 306
VAL A 308
 None
 1.24A 4c9kB-4l4xA:
undetectable		 4c9kB-4l4xA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 11 LEU A  80
LEU A 101
LEU A 238
ALA A 230
LEU A 234
 None
 1.17A 4wg0F-4l4xA:
undetectable
4wg0G-4l4xA:
undetectable
4wg0H-4l4xA:
undetectable		 4wg0F-4l4xA:
2.14
4wg0G-4l4xA:
2.14
4wg0H-4l4xA:
2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 11 LEU A  80
LEU A 101
LEU A 238
ALA A 230
LEU A 234
 None
 1.16A 4wg0H-4l4xA:
undetectable
4wg0I-4l4xA:
undetectable
4wg0J-4l4xA:
undetectable		 4wg0H-4l4xA:
2.14
4wg0I-4l4xA:
2.14
4wg0J-4l4xA:
2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 11 ALA A 230
LEU A 234
LEU A 238
LEU A  80
LEU A 101
 None
 1.19A 4wg0G-4l4xA:
undetectable
4wg0H-4l4xA:
undetectable
4wg0I-4l4xA:
undetectable		 4wg0G-4l4xA:
2.14
4wg0H-4l4xA:
2.14
4wg0I-4l4xA:
2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 11 LEU A  80
LEU A 101
LEU A 238
ALA A 230
LEU A 234
 None
 1.14A 4wg0J-4l4xA:
undetectable
4wg0K-4l4xA:
undetectable
4wg0L-4l4xA:
undetectable		 4wg0J-4l4xA:
2.14
4wg0K-4l4xA:
2.14
4wg0L-4l4xA:
2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 11 ALA A 230
LEU A 234
LEU A 238
LEU A  80
LEU A 101
 None
 1.19A 4wg0I-4l4xA:
undetectable
4wg0J-4l4xA:
undetectable
4wg0K-4l4xA:
undetectable		 4wg0I-4l4xA:
2.14
4wg0J-4l4xA:
2.14
4wg0K-4l4xA:
2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l4x AMPHI
(Streptomyces
nodosus) 		4 / 7 VAL A 502
TRP A 504
HIS A 508
GLU A 505
 None
 1.30A 5ad9A-4l4xA:
undetectable
5ad9B-4l4xA:
undetectable		 5ad9A-4l4xA:
20.27
5ad9B-4l4xA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4l4x AMPHI
(Streptomyces
nodosus) 		4 / 5 GLU A 331
THR A 330
HIS A 364
LEU A 281
 None
 1.17A 5axaA-4l4xA:
5.2		 5axaA-4l4xA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4l4x AMPHI
(Streptomyces
nodosus) 		4 / 5 GLU A 331
THR A 330
HIS A 364
LEU A 281
 None
 1.21A 5axaC-4l4xA:
5.1		 5axaC-4l4xA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 11 TYR A 507
TYR A 511
GLY A 419
GLY A 421
ALA A 415
 None
 1.33A 5e3iB-4l4xA:
undetectable		 5e3iB-4l4xA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 12 LEU A 305
LEU A 325
ALA A 298
ARG A 295
LEU A 490
 None
 1.17A 5h8tA-4l4xA:
undetectable		 5h8tA-4l4xA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4l4x AMPHI
(Streptomyces
nodosus) 		4 / 4 LEU A 334
GLY A 312
SER A 309
SER A 286
 None
None
NDP  A 601 (-2.4A)
NDP  A 601 (-3.3A)
 1.25A 5uunA-4l4xA:
undetectable		 5uunA-4l4xA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 4l4x AMPHI
(Streptomyces
nodosus) 		4 / 7 GLY A 240
GLN A 247
TRP A 178
ASP A 245
 None
 1.20A 5vlmG-4l4xA:
undetectable		 5vlmG-4l4xA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 9 ALA A 143
ALA A  89
LEU A 111
CYH A 117
LEU A  86
 None
 1.35A 6ay6A-4l4xA:
undetectable		 6ay6A-4l4xA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4l4x AMPHI
(Streptomyces
nodosus) 		5 / 11 ALA A 302
LEU A 483
TRP A 274
ALA A 298
LEU A 325
 None
 1.28A 6dk1B-4l4xA:
undetectable		 6dk1B-4l4xA:
19.04