SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 4l4y TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 12 THR A 306
PHE A  82
VAL A 280
ALA A 294
ALA A 291
 None
 1.18A 1nw5A-4l4yA:
undetectable		 1nw5A-4l4yA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 4l4y TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 11 LEU A 132
VAL A 280
GLY A 281
ALA A 106
LEU A 110
 None
 0.76A 2bxgA-4l4yA:
undetectable		 2bxgA-4l4yA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4l4y TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 11 ASN A 302
GLY A 298
ILE A 244
LYS A 274
LEU A 273
 None
 1.42A 3bexC-4l4yA:
undetectable
3bexD-4l4yA:
undetectable		 3bexC-4l4yA:
19.66
3bexD-4l4yA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4l4y TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 10 LYS A 274
LEU A 273
ASN A 302
GLY A 298
ILE A 244
 None
 1.42A 3bexC-4l4yA:
undetectable
3bexD-4l4yA:
undetectable		 3bexC-4l4yA:
19.66
3bexD-4l4yA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4l4y TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 10 ASN A 302
GLY A 298
ILE A 244
LYS A 274
LEU A 273
 None
 1.41A 3bexE-4l4yA:
undetectable
3bexF-4l4yA:
undetectable		 3bexE-4l4yA:
19.66
3bexF-4l4yA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4l4y TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 11 ASN A 302
GLY A 298
ILE A 244
LYS A 274
LEU A 273
 None
 1.43A 3bf1C-4l4yA:
undetectable
3bf1D-4l4yA:
undetectable		 3bf1C-4l4yA:
19.66
3bf1D-4l4yA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4l4y TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 11 LYS A 274
LEU A 273
ASN A 302
GLY A 298
ILE A 244
 None
 1.38A 3bf1C-4l4yA:
undetectable
3bf1D-4l4yA:
undetectable		 3bf1C-4l4yA:
19.66
3bf1D-4l4yA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 4l4y TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 9 LEU A  84
ILE A 207
GLY A 209
ILE A 210
VAL A  87
 None
 1.07A 3d1yB-4l4yA:
undetectable		 3d1yB-4l4yA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4l4y TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 12 GLY A 103
GLY A 100
ALA A 127
THR A 131
LEU A 135
 None
 1.10A 3dh0B-4l4yA:
4.7		 3dh0B-4l4yA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 4l4y TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		4 / 7 GLY A 298
ASP A 254
ASP A 250
VAL A 241
 None
 0.78A 3t3cA-4l4yA:
undetectable		 3t3cA-4l4yA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4l4y TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 10 LEU A 149
GLY A 123
THR A 128
VAL A 282
ILE A 210
 None
 1.17A 4jx1B-4l4yA:
undetectable		 4jx1B-4l4yA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4l4y TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 12 TYR A 156
GLY A 125
ILE A 207
MET A 129
GLY A 281
 None
 1.25A 4obwA-4l4yA:
5.6		 4obwA-4l4yA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4l4y TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 12 TYR A 156
GLY A 125
ILE A 207
MET A 129
GLY A 281
 None
 1.24A 4obwD-4l4yA:
5.0		 4obwD-4l4yA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 4l4y TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 11 LEU A 120
ALA A 206
ILE A 172
GLY A 267
LEU A 268
 None
 1.15A 4pxmB-4l4yA:
undetectable		 4pxmB-4l4yA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4l4y TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 12 LEU A 120
ALA A 206
ILE A 172
GLY A 267
LEU A 268
 None
 1.15A 5gs4A-4l4yA:
undetectable		 5gs4A-4l4yA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 4l4y TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		4 / 6 THR A 148
LEU A 149
MET A 129
LEU A 265
 None
 1.12A 6mvxA-4l4yA:
undetectable
6mvxB-4l4yA:
undetectable
6mvxC-4l4yA:
undetectable		 6mvxA-4l4yA:
21.17
6mvxB-4l4yA:
21.17
6mvxC-4l4yA:
21.17