SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4l59 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN 3
(Homo
sapiens) 		3 / 3 VAL A 266
LYS A 265
HIS A 538
 None
 0.71A 3elzA-4l59A:
undetectable		 3elzA-4l59A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		 4l59 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN 3
(Homo
sapiens) 		5 / 12 SER A 420
CYH A 416
PHE A 401
TYR A 414
ALA A 391
 None
 1.19A 4hwkC-4l59A:
undetectable		 4hwkC-4l59A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		 4l59 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN 3
(Homo
sapiens) 		5 / 11 SER A 420
CYH A 416
PHE A 401
TYR A 414
ALA A 391
 None
 1.19A 4hwkD-4l59A:
undetectable		 4hwkD-4l59A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 4l59 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN 3
(Homo
sapiens) 		5 / 12 SER A 420
CYH A 416
PHE A 401
TYR A 414
ALA A 391
 None
 1.19A 4j7xA-4l59A:
undetectable		 4j7xA-4l59A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4l59 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN 3
(Homo
sapiens) 		4 / 6 PHE A 387
ARG A 434
THR A 435
ILE A 437
 None
 1.35A 5ih0A-4l59A:
undetectable		 5ih0A-4l59A:
19.34