SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l5f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4l5f HEAVY CHAIN OF E106
ANTIBODY (VH AND CH1
OF IGG2C)
(Mus
musculus) 		5 / 11 TRP H 103
TRP H  98
ILE H  34
LEU H 100
ALA H  99
 None
 1.47A 1jb0B-4l5fH:
undetectable		 1jb0B-4l5fH:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 4l5f HEAVY CHAIN OF E106
ANTIBODY (VH AND CH1
OF IGG2C)
LIGHT CHAIN OF E106
ANTIBODY (KAPPA)
(Mus
musculus) 		4 / 8 LEU L  89
TRP H  47
LEU H 100
TYR L  36
 None
 1.02A 1s1xA-4l5fL:
undetectable		 1s1xA-4l5fL:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 4l5f HEAVY CHAIN OF E106
ANTIBODY (VH AND CH1
OF IGG2C)
LIGHT CHAIN OF E106
ANTIBODY (KAPPA)
(Mus
musculus) 		4 / 6 ASN L  34
SER L  49
ALA H  99
ASP H 101
 None
 1.33A 3aruA-4l5fL:
5.5		 3aruA-4l5fL:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4l5f HEAVY CHAIN OF E106
ANTIBODY (VH AND CH1
OF IGG2C)
LIGHT CHAIN OF E106
ANTIBODY (KAPPA)
(Mus
musculus) 		4 / 8 GLU L  50
ASN H  97
ASN L  34
ILE L  48
 None
 1.29A 3kp6A-4l5fL:
undetectable
3kp6B-4l5fL:
undetectable		 3kp6A-4l5fL:
22.64
3kp6B-4l5fL:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 4l5f LIGHT CHAIN OF E106
ANTIBODY (KAPPA)
(Mus
musculus) 		4 / 6 PHE L  73
PHE L  62
THR L  74
VAL L  19
 None
 1.27A 3lb3A-4l5fL:
undetectable		 3lb3A-4l5fL:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4l5f HEAVY CHAIN OF E106
ANTIBODY (VH AND CH1
OF IGG2C)
(Mus
musculus) 		5 / 11 TRP H 103
TRP H  98
ILE H  34
LEU H 100
ALA H  99
 None
 1.47A 3pcqB-4l5fH:
undetectable		 3pcqB-4l5fH:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4l5f LIGHT CHAIN OF E106
ANTIBODY (KAPPA)
(Mus
musculus) 		4 / 7 PRO L   8
SER L  12
GLU L 105
ASP L 110
 None
 1.06A 4uacA-4l5fL:
undetectable		 4uacA-4l5fL:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4l5f HEAVY CHAIN OF E106
ANTIBODY (VH AND CH1
OF IGG2C)
(Mus
musculus) 		5 / 10 TRP H 103
TRP H  98
ILE H  34
LEU H 100
ALA H  99
 None
 1.42A 4xk8B-4l5fH:
undetectable		 4xk8B-4l5fH:
14.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 4l5f HEAVY CHAIN OF E106
ANTIBODY (VH AND CH1
OF IGG2C)
(Mus
musculus) 		4 / 5 SER H 112
ALA H 114
PHE H 146
LEU H 170
 None
 0.20A 5mthA-4l5fH:
30.1		 5mthA-4l5fH:
75.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4l5f HEAVY CHAIN OF E106
ANTIBODY (VH AND CH1
OF IGG2C)
LIGHT CHAIN OF E106
ANTIBODY (KAPPA)
(Mus
musculus;
Mus
musculus) 		5 / 12 LEU L 160
THR L 178
VAL L 133
SER L 131
THR H 117
 None
 1.40A 5v1tA-4l5fL:
undetectable		 5v1tA-4l5fL:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 4l5f HEAVY CHAIN OF E106
ANTIBODY (VH AND CH1
OF IGG2C)
(Mus
musculus) 		3 / 3 SER H 203
ALA H 198
VAL H 197
 None
 0.54A 5xiwC-4l5fH:
undetectable		 5xiwC-4l5fH:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4l5f HEAVY CHAIN OF E106
ANTIBODY (VH AND CH1
OF IGG2C)
(Mus
musculus) 		5 / 10 TRP H 103
TRP H  98
ILE H  34
LEU H 100
ALA H  99
 None
 1.47A 5zjiB-4l5fH:
undetectable		 5zjiB-4l5fH:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 4l5f LIGHT CHAIN OF E106
ANTIBODY (KAPPA)
(Mus
musculus) 		4 / 6 THR L  97
LEU L  96
MET L  33
THR L  25
 None
 1.19A 6mvxA-4l5fL:
undetectable
6mvxB-4l5fL:
undetectable
6mvxC-4l5fL:
undetectable		 6mvxA-4l5fL:
18.79
6mvxB-4l5fL:
18.79
6mvxC-4l5fL:
18.79