SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 12 ILE A 160
SER A 150
MET A 129
LEU A 176
TYR A 226
 None
 1.42A 1fm6X-4l5iA:
undetectable		 1fm6X-4l5iA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 12 THR A 306
PHE A  82
VAL A 280
ALA A 294
ALA A 291
 None
 1.29A 1nw5A-4l5iA:
undetectable		 1nw5A-4l5iA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 11 LEU A 132
VAL A 280
GLY A 281
ALA A 106
LEU A 110
 None
 0.88A 2bxgA-4l5iA:
undetectable		 2bxgA-4l5iA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 11 LEU A 315
ALA A 311
ILE A 314
VAL A  87
ILE A 301
 None
 1.09A 3b2rB-4l5iA:
undetectable		 3b2rB-4l5iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 9 LEU A  84
ILE A 207
GLY A 209
ILE A 210
VAL A  87
 None
 1.08A 3d1yB-4l5iA:
undetectable		 3d1yB-4l5iA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 12 GLY A 103
GLY A 100
ALA A 127
THR A 131
LEU A 135
 None
 1.12A 3dh0B-4l5iA:
4.3		 3dh0B-4l5iA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		4 / 7 LEU A 268
LEU A 110
VAL A 208
LEU A 163
 None
 0.94A 3g8iA-4l5iA:
undetectable		 3g8iA-4l5iA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 9 PHE A 249
GLY A 209
ALA A 283
THR A 306
ILE A 314
 None
 1.43A 3jusB-4l5iA:
undetectable		 3jusB-4l5iA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 10 LEU A 120
ILE A 171
VAL A 169
GLY A 161
LEU A 146
 None
 0.76A 3ogqA-4l5iA:
undetectable		 3ogqA-4l5iA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		4 / 8 HIS A 108
ILE A 104
ILE A  90
ARG A  88
 None
 0.97A 3sfeB-4l5iA:
undetectable
3sfeC-4l5iA:
undetectable		 3sfeB-4l5iA:
20.96
3sfeC-4l5iA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		6 / 12 LEU A 265
THR A 220
ILE A 221
ILE A 266
ALA A 174
PHE A 124
 None
 1.40A 3vw1D-4l5iA:
2.1		 3vw1D-4l5iA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 12 GLY A 242
ALA A 240
PHE A 249
LEU A 270
ILE A 259
 None
 1.12A 4hytA-4l5iA:
2.3		 4hytA-4l5iA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 12 GLY A 242
ALA A 240
PHE A 249
LEU A 270
ILE A 259
 None
 1.14A 4hytC-4l5iA:
undetectable		 4hytC-4l5iA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 10 LEU A 149
GLY A 123
THR A 128
VAL A 282
ILE A 210
 None
 1.14A 4jx1B-4l5iA:
undetectable		 4jx1B-4l5iA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 10 TYR A 156
TYR A 226
GLY A 123
SER A 155
ASP A 243
 None
 1.35A 4mmcA-4l5iA:
undetectable		 4mmcA-4l5iA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 11 LEU A 120
ALA A 206
ILE A 172
GLY A 267
LEU A 268
 None
 1.18A 4pxmB-4l5iA:
undetectable		 4pxmB-4l5iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 12 LEU A 120
ALA A 206
ILE A 172
GLY A 267
LEU A 268
 None
 1.17A 5gs4A-4l5iA:
undetectable		 5gs4A-4l5iA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		6 / 12 GLY A 105
VAL A 305
ALA A 303
LEU A 120
LEU A 113
ILE A 207
 None
 0.99A 5hieA-4l5iA:
undetectable		 5hieA-4l5iA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 12 THR A 220
GLY A 285
ALA A 283
THR A 306
SER A 214
 None
 1.21A 5lf3N-4l5iA:
undetectable		 5lf3N-4l5iA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		5 / 12 LEU A 132
ILE A 160
GLY A 125
LEU A 245
ILE A 207
 None
 1.11A 5m24A-4l5iA:
undetectable		 5m24A-4l5iA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		4 / 4 GLY A 281
ALA A 283
MET A 296
THR A 310
 None
 1.23A 5n0sB-4l5iA:
undetectable		 5n0sB-4l5iA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 4l5i TRANSCRIPTIONAL
REGULATOR LSRR
(Escherichia
coli) 		4 / 6 THR A 148
LEU A 149
MET A 129
LEU A 265
 None
 1.16A 6mvxA-4l5iA:
undetectable
6mvxB-4l5iA:
undetectable
6mvxC-4l5iA:
undetectable		 6mvxA-4l5iA:
23.21
6mvxB-4l5iA:
23.21
6mvxC-4l5iA:
23.21