SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 4l5n URACIL-DNA
GLYCOSYLASE
(Human
alphaherpesvirus
1) 		5 / 12 GLY A 133
SER A 102
VAL A 116
LEU A 113
LEU A 117
 None
 1.06A 1mx1F-4l5nA:
undetectable		 1mx1F-4l5nA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4l5n URACIL-DNA
GLYCOSYLASE
EARLY PROTEIN GP1B
(Human
alphaherpesvirus
1;
Bacillus
virus
phi29) 		3 / 3 MET C  14
ASN C  42
GLN A  95
 None
ACT  A 301 ( 4.9A)
None
 1.04A 1xoqB-4l5nC:
undetectable		 1xoqB-4l5nC:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 4l5n URACIL-DNA
GLYCOSYLASE
(Human
alphaherpesvirus
1) 		5 / 10 TYR A  90
PHE A 225
LEU A 135
LEU A 145
ILE A  84
 None
 1.06A 2bxeB-4l5nA:
undetectable		 2bxeB-4l5nA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4l5n URACIL-DNA
GLYCOSYLASE
(Human
alphaherpesvirus
1) 		3 / 3 ILE A  84
PHE A 225
HIS A 210
 None
 0.76A 3h0aA-4l5nA:
undetectable		 3h0aA-4l5nA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4l5n URACIL-DNA
GLYCOSYLASE
(Human
alphaherpesvirus
1) 		4 / 8 LEU A 187
ILE A 173
VAL A 169
GLY A  86
 None
ACT  A 304 ( 4.5A)
None
None
 0.90A 4eq4B-4l5nA:
undetectable		 4eq4B-4l5nA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4l5n URACIL-DNA
GLYCOSYLASE
EARLY PROTEIN GP1B
(Human
alphaherpesvirus
1;
Bacillus
virus
phi29) 		4 / 8 HIS A 191
ASP C  35
ALA A 158
SER C  32
 None
ACT  A 301 (-4.8A)
ACT  A 301 ( 3.8A)
None
 1.05A 4k0bB-4l5nA:
undetectable		 4k0bB-4l5nA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 4l5n EARLY PROTEIN GP1B
URACIL-DNA
GLYCOSYLASE
(Bacillus
virus
phi29;
Human
alphaherpesvirus
1) 		4 / 6 HIS A  91
HIS A  92
TYR C  24
GLU C  26
 None
 1.02A 4pahA-4l5nA:
undetectable		 4pahA-4l5nA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 4l5n EARLY PROTEIN GP1B
URACIL-DNA
GLYCOSYLASE
(Bacillus
virus
phi29;
Human
alphaherpesvirus
1) 		4 / 6 LEU C  50
HIS A  91
HIS A  92
TYR C  24
 None
 1.10A 4pahA-4l5nC:
undetectable		 4pahA-4l5nC:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4l5n URACIL-DNA
GLYCOSYLASE
(Human
alphaherpesvirus
1) 		3 / 3 PRO A  93
VAL A 152
HIS A 160
 None
 0.80A 4pevC-4l5nA:
2.9		 4pevC-4l5nA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4l5n EARLY PROTEIN GP1B
URACIL-DNA
GLYCOSYLASE
(Bacillus
virus
phi29;
Human
alphaherpesvirus
1) 		4 / 8 ILE C  47
PHE C  36
LEU C  50
LEU A 214
 None
 0.88A 4qopC-4l5nC:
undetectable		 4qopC-4l5nC:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4l5n URACIL-DNA
GLYCOSYLASE
(Human
alphaherpesvirus
1) 		4 / 5 LEU A  99
VAL A  83
TYR A  74
ARG A 167
 None
 1.08A 4r7iA-4l5nA:
undetectable		 4r7iA-4l5nA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 4l5n URACIL-DNA
GLYCOSYLASE
(Human
alphaherpesvirus
1) 		4 / 6 LEU A 206
LEU A 226
VAL A 227
PHE A 225
 None
 1.23A 4uswA-4l5nA:
undetectable		 4uswA-4l5nA:
19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4l5n URACIL-DNA
GLYCOSYLASE
(Human
alphaherpesvirus
1) 		4 / 8 GLN A  87
PHE A 101
SER A 112
HIS A 210
 ACT  A 301 (-3.6A)
None
None
None
 0.77A 4wryA-4l5nA:
28.0		 4wryA-4l5nA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4l5n URACIL-DNA
GLYCOSYLASE
(Human
alphaherpesvirus
1) 		4 / 8 GLY A  86
GLN A  87
PHE A 101
SER A 112
 None
ACT  A 301 (-3.6A)
None
None
 0.75A 4wryA-4l5nA:
28.0		 4wryA-4l5nA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4l5n URACIL-DNA
GLYCOSYLASE
(Human
alphaherpesvirus
1) 		5 / 8 GLY A  86
GLN A  87
TYR A  90
PHE A 101
ASN A 147
 None
ACT  A 301 (-3.6A)
None
None
None
 0.75A 4wryA-4l5nA:
28.0		 4wryA-4l5nA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4l5n URACIL-DNA
GLYCOSYLASE
(Human
alphaherpesvirus
1) 		5 / 8 GLY A  86
GLN A  87
PHE A 101
SER A 112
ASN A 147
 None
ACT  A 301 (-3.6A)
None
None
None
 0.80A 4wrzA-4l5nA:
27.4		 4wrzA-4l5nA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4l5n URACIL-DNA
GLYCOSYLASE
(Human
alphaherpesvirus
1) 		5 / 8 GLY A  86
GLN A  87
TYR A  90
PHE A 101
ASN A 147
 None
ACT  A 301 (-3.6A)
None
None
None
 0.76A 4wrzA-4l5nA:
27.4		 4wrzA-4l5nA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4l5n URACIL-DNA
GLYCOSYLASE
(Human
alphaherpesvirus
1) 		5 / 7 GLY A  86
GLN A  87
TYR A  90
PHE A 101
ASN A 147
 None
ACT  A 301 (-3.6A)
None
None
None
 0.83A 4ws0A-4l5nA:
28.0		 4ws0A-4l5nA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4l5n URACIL-DNA
GLYCOSYLASE
(Human
alphaherpesvirus
1) 		5 / 8 GLY A  86
GLN A  87
TYR A  90
PHE A 101
ASN A 147
 None
ACT  A 301 (-3.6A)
None
None
None
 0.83A 4ws1A-4l5nA:
28.0		 4ws1A-4l5nA:
37.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4l5n EARLY PROTEIN GP1B
URACIL-DNA
GLYCOSYLASE
(Bacillus
virus
phi29;
Human
alphaherpesvirus
1) 		4 / 4 HIS A  91
HIS A  92
TYR C  24
GLU C  26
 None
 1.03A 5pahA-4l5nA:
undetectable		 5pahA-4l5nA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4l5n EARLY PROTEIN GP1B
URACIL-DNA
GLYCOSYLASE
(Bacillus
virus
phi29;
Human
alphaherpesvirus
1) 		4 / 6 HIS A  91
HIS A  92
TYR C  24
GLU C  26
 None
 1.04A 6pahA-4l5nA:
undetectable		 6pahA-4l5nA:
22.51