SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l5o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4l5o PUTATIVE GLUTATHIONE
TRANSFERASE
(Clonorchis
sinensis) 		4 / 7 TYR A   7
GLY A  12
TYR A 111
GLY A 205
 None
 0.80A 11gsB-4l5oA:
25.1		 11gsB-4l5oA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4l5o PUTATIVE GLUTATHIONE
TRANSFERASE
(Clonorchis
sinensis) 		3 / 3 ASP A  37
HIS A  31
ASP A  44
 None
 0.53A 1nw5A-4l5oA:
undetectable		 1nw5A-4l5oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 4l5o PUTATIVE GLUTATHIONE
TRANSFERASE
(Clonorchis
sinensis) 		5 / 12 LEU A 102
ALA A 158
LEU A  19
PRO A  16
LEU A  72
 None
 1.23A 1og5A-4l5oA:
undetectable		 1og5A-4l5oA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4l5o PUTATIVE GLUTATHIONE
TRANSFERASE
(Clonorchis
sinensis) 		4 / 7 GLY A 211
GLY A 212
VAL A 106
LEU A 165
 None
 0.76A 2oa1B-4l5oA:
undetectable		 2oa1B-4l5oA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 4l5o PUTATIVE GLUTATHIONE
TRANSFERASE
(Clonorchis
sinensis) 		4 / 8 ILE A  75
HIS A  79
LEU A  20
GLY A  25
 None
ZN  A 303 (-3.0A)
None
None
 0.90A 2vdbA-4l5oA:
undetectable		 2vdbA-4l5oA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4l5o PUTATIVE GLUTATHIONE
TRANSFERASE
(Clonorchis
sinensis) 		3 / 3 LEU A 123
TYR A 122
GLN A 125
 None
 0.74A 2wekA-4l5oA:
undetectable		 2wekA-4l5oA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4l5o PUTATIVE GLUTATHIONE
TRANSFERASE
(Clonorchis
sinensis) 		4 / 6 GLY A 205
ARG A  18
GLU A 157
ARG A 103
 None
 1.45A 4bqfA-4l5oA:
undetectable		 4bqfA-4l5oA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4l5o PUTATIVE GLUTATHIONE
TRANSFERASE
(Clonorchis
sinensis) 		4 / 6 TRP A  41
ASN A  47
TYR A  57
LEU A  50
 GSH  A 301 (-4.1A)
None
None
None
 1.27A 4f8yA-4l5oA:
undetectable
4f8yB-4l5oA:
undetectable		 4f8yA-4l5oA:
18.07
4f8yB-4l5oA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4l5o PUTATIVE GLUTATHIONE
TRANSFERASE
(Clonorchis
sinensis) 		4 / 7 TYR A  57
LEU A  50
TRP A  41
ASN A  47
 None
None
GSH  A 301 (-4.1A)
None
 1.24A 4f8yC-4l5oA:
undetectable
4f8yD-4l5oA:
undetectable		 4f8yC-4l5oA:
18.07
4f8yD-4l5oA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 4l5o PUTATIVE GLUTATHIONE
TRANSFERASE
(Clonorchis
sinensis) 		4 / 7 ILE A  75
HIS A  79
LEU A  20
GLY A  25
 None
ZN  A 303 (-3.0A)
None
None
 1.04A 4z69A-4l5oA:
undetectable		 4z69A-4l5oA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 4l5o PUTATIVE GLUTATHIONE
TRANSFERASE
(Clonorchis
sinensis) 		4 / 7 VAL A 106
SER A 107
ALA A 110
GLY A 211
 None
 0.64A 5fpdA-4l5oA:
undetectable		 5fpdA-4l5oA:
19.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 4l5o PUTATIVE GLUTATHIONE
TRANSFERASE
(Clonorchis
sinensis) 		4 / 5 GLY A  12
LEU A  13
SER A 107
TYR A 111
 None
GSH  A 301 (-4.4A)
None
None
 0.27A 6ji6A-4l5oA:
33.7		 6ji6A-4l5oA:
59.17