SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FE2_A_LAXA700_1 (PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1)	4l5t	INTERFERON-ACTIVABLE PROTEIN 202 (Mus musculus)	6 / 10	VAL A 368 VAL A 406 VAL A 399 VAL A 397 ILE A 356 LEU A 416	None	1.46A	1fe2A-4l5tA: undetectable	1fe2A-4l5tA: 14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA3_A_STRA1001_1 (MINERALOCORTICOID RECEPTOR)	4l5t	INTERFERON-ACTIVABLE PROTEIN 202 (Mus musculus)	5 / 12	LEU A 367 LEU A 324 ALA A 325 MET A 281 THR A 433	None	1.48A	1ya3A-4l5tA: undetectable	1ya3A-4l5tA: 22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LB0_B_ACTB401_0 (UNCHARACTERIZED PROTEIN)	4l5t	INTERFERON-ACTIVABLE PROTEIN 202 (Mus musculus)	4 / 5	VAL A 286 LEU A 314 VAL A 332 PHE A 306	None	1.02A	4lb0B-4l5tA: undetectable	4lb0B-4l5tA: 19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R29_D_SAMD301_1 (UNCHARACTERIZED PROTEIN)	4l5t	INTERFERON-ACTIVABLE PROTEIN 202 (Mus musculus)	3 / 3	ARG A 376 GLU A 427 TYR A 375	None	1.02A	4r29D-4l5tA: undetectable	4r29D-4l5tA: 22.95

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FE2_A_LAXA700_1","PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1","4l5t","INTERFERON-ACTIVABLE PROTEIN 202","Mus musculus",6,"VAL A 368;VAL A 406;VAL A 399;VAL A 397;ILE A 356;LEU A 416","None","1.46A","1fe2A-4l5tA:undetectable","1fe2A-4l5tA:14.93"],["1YA3_A_STRA1001_1","MINERALOCORTICOID RECEPTOR","4l5t","INTERFERON-ACTIVABLE PROTEIN 202","Mus musculus",5,"LEU A 367;LEU A 324;ALA A 325;MET A 281;THR A 433","None","1.48A","1ya3A-4l5tA:undetectable","1ya3A-4l5tA:22.68"],["4LB0_B_ACTB401_0","UNCHARACTERIZED PROTEIN","4l5t","INTERFERON-ACTIVABLE PROTEIN 202","Mus musculus",4,"VAL A 286;LEU A 314;VAL A 332;PHE A 306","None","1.02A","4lb0B-4l5tA:undetectable","4lb0B-4l5tA:19.88"],["4R29_D_SAMD301_1","UNCHARACTERIZED PROTEIN","4l5t","INTERFERON-ACTIVABLE PROTEIN 202","Mus musculus",3,"ARG A 376;GLU A 427;TYR A 375","None","1.02A","4r29D-4l5tA:undetectable","4r29D-4l5tA:22.95"]]