SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l60'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  16
GLY A  18
GLY A 218
SER A 219
VAL A  48
 None
 1.02A 1vq1B-4l60A:
undetectable		 1vq1B-4l60A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		5 / 10 ASN A 159
ILE A 158
ILE A 227
LEU A 229
PHE A 237
 None
 1.09A 1z11C-4l60A:
undetectable		 1z11C-4l60A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		5 / 10 ASN A 159
ILE A 158
ILE A 227
LEU A 229
PHE A 237
 None
 1.12A 1z11D-4l60A:
undetectable		 1z11D-4l60A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		6 / 12 ALA A 209
LEU A 250
PHE A 207
ILE A 227
LEU A 229
ILE A 160
 None
 1.39A 2d0kB-4l60A:
undetectable		 2d0kB-4l60A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 236
ALA A 235
ILE A 160
ILE A 128
PHE A 248
 None
 1.19A 2ejtA-4l60A:
undetectable		 2ejtA-4l60A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		5 / 12 PHE A   6
LYS A 242
ILE A  35
PHE A  57
LEU A  79
 None
 1.22A 2lbdA-4l60A:
undetectable		 2lbdA-4l60A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		4 / 4 ARG A 224
GLN A 238
PHE A 237
LEU A 139
 None
 1.12A 3abkC-4l60A:
undetectable		 3abkC-4l60A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 224
GLN A 238
PHE A 237
LEU A 139
 None
 1.13A 3ablC-4l60A:
undetectable
3ablJ-4l60A:
undetectable		 3ablC-4l60A:
21.54
3ablJ-4l60A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 224
GLN A 238
PHE A 237
LEU A 139
 None
 1.14A 3ablP-4l60A:
undetectable
3ablW-4l60A:
undetectable		 3ablP-4l60A:
21.54
3ablW-4l60A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  99
LEU A  50
ILE A  16
SER A  76
LEU A  88
 None
 1.17A 3cd2A-4l60A:
undetectable		 3cd2A-4l60A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  57
GLY A 244
ILE A  15
LEU A  11
 None
 0.82A 4ejjD-4l60A:
undetectable		 4ejjD-4l60A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 160
PHE A 237
PHE A 239
ILE A 182
 None
 0.97A 4qogA-4l60A:
undetectable
4qogB-4l60A:
undetectable		 4qogA-4l60A:
22.70
4qogB-4l60A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 224
GLN A 238
PHE A 237
LEU A 139
 None
 1.07A 5b1bC-4l60A:
undetectable
5b1bJ-4l60A:
undetectable		 5b1bC-4l60A:
21.54
5b1bJ-4l60A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		4 / 5 GLY A  18
ASP A  17
MET A  70
MET A 119
 None
 1.37A 5gwkA-4l60A:
undetectable		 5gwkA-4l60A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		4 / 4 ARG A 224
GLN A 238
PHE A 237
LEU A 139
 None
 1.21A 6nmfC-4l60A:
0.0		 6nmfC-4l60A:
21.54