SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l62'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)
4l62 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa)
5 / 12 TYR A 162
SER A 111
TYR A  62
PHE A  63
TYR A  66
None
1.22A 1maaC-4l62A:
undetectable
1maaC-4l62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)
4l62 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa)
5 / 11 TYR A  62
LEU A 125
GLU A 113
VAL A 114
LEU A 166
None
1.25A 1mrqA-4l62A:
undetectable
1mrqA-4l62A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)
4l62 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa)
5 / 10 LEU A  85
GLY A 138
ASP A  71
GLY A 131
ILE A 133
None
0.94A 1t7iA-4l62A:
undetectable
1t7iA-4l62A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
4l62 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa)
4 / 7 VAL A 114
SER A 118
LEU A 106
THR A 124
None
1.08A 2f78A-4l62A:
undetectable
2f78A-4l62A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)
4l62 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa)
5 / 12 LEU A  85
GLY A 138
ASP A  71
GLY A 131
ILE A 133
None
0.83A 3jvyB-4l62A:
undetectable
3jvyB-4l62A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)
4l62 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa)
3 / 3 ASP A  14
ARG A  18
ARG A  64
None
0.76A 3k37A-4l62A:
undetectable
3k37A-4l62A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)
4l62 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa)
5 / 10 LEU A  85
GLY A 138
ASP A  71
GLY A 131
ILE A 133
None
0.96A 3oy4B-4l62A:
undetectable
3oy4B-4l62A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)
4l62 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa)
5 / 10 LEU A  85
GLY A 138
ASP A  71
GLY A 131
ILE A 133
None
0.99A 4njtB-4l62A:
undetectable
4njtB-4l62A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)
4l62 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa)
5 / 9 LEU A  85
GLY A 138
ASP A  71
GLY A 131
ILE A 133
None
0.97A 4q1wA-4l62A:
undetectable
4q1wA-4l62A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)
4l62 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa)
5 / 10 LEU A  85
GLY A 138
ASP A  71
GLY A 131
ILE A 133
None
0.93A 4q1yA-4l62A:
undetectable
4q1yA-4l62A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)
4l62 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa)
3 / 5 GLY A  27
GLY A  29
GLU A  32
None
0.52A 4z2eA-4l62A:
undetectable
4z2eD-4l62A:
undetectable
4z2eA-4l62A:
17.00
4z2eD-4l62A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)
4l62 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa)
5 / 10 ASP A  71
LEU A  67
LEU A 136
LEU A 140
ALA A 158
None
1.19A 4zbrA-4l62A:
5.1
4zbrA-4l62A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4l62 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa)
4 / 5 ARG A 122
MET A 121
THR A 124
LEU A  59
None
1.40A 5w97J-4l62A:
undetectable
5w97J-4l62A:
17.54