SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 4l63 ECXA
(Escherichia
coli) 		4 / 8 SER A 111
SER A 133
ASN A 132
THR A 125
 None
 1.10A 1ig3A-4l63A:
undetectable
1ig3B-4l63A:
undetectable		 1ig3A-4l63A:
21.53
1ig3B-4l63A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 4l63 ECXA
(Escherichia
coli) 		4 / 5 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.16A 1os2A-4l63A:
11.6		 1os2A-4l63A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 4l63 ECXA
(Escherichia
coli) 		4 / 4 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.17A 1os2D-4l63A:
11.7		 1os2D-4l63A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 4l63 ECXA
(Escherichia
coli) 		5 / 10 THR A 176
HIS A 179
GLU A 180
HIS A 183
HIS A 189
 None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.36A 1r55A-4l63A:
6.3		 1r55A-4l63A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 4l63 ECXB
(Escherichia
coli) 		5 / 12 ILE B  24
VAL B  50
ASP B  70
ALA B  74
THR B  78
 None
 1.10A 1r9oA-4l63B:
undetectable		 1r9oA-4l63B:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 4l63 ECXA
(Escherichia
coli) 		5 / 8 PHE A 112
SER A 111
ILE A  47
THR A 125
THR A 135
 None
 0.91A 1sbrA-4l63A:
undetectable		 1sbrA-4l63A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 4l63 ECXA
(Escherichia
coli) 		4 / 8 SER A 111
ILE A  44
THR A 125
THR A 135
 None
 0.94A 1sbrA-4l63A:
undetectable		 1sbrA-4l63A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 4l63 ECXA
(Escherichia
coli) 		5 / 7 PHE A 112
SER A 111
ILE A  47
THR A 125
THR A 135
 None
 0.95A 1sbrB-4l63A:
undetectable		 1sbrB-4l63A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 4l63 ECXA
(Escherichia
coli) 		4 / 7 SER A 111
ILE A  44
THR A 125
THR A 135
 None
 0.94A 1sbrB-4l63A:
undetectable		 1sbrB-4l63A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 4l63 ECXA
(Escherichia
coli) 		4 / 4 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.16A 1uttA-4l63A:
11.7		 1uttA-4l63A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 4l63 ECXA
(Escherichia
coli) 		4 / 4 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.16A 1utzA-4l63A:
11.6		 1utzA-4l63A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 4l63 ECXA
(Escherichia
coli) 		4 / 4 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.18A 1utzB-4l63A:
11.6		 1utzB-4l63A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4l63 ECXA
(Escherichia
coli) 		4 / 6 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.17A 1y93A-4l63A:
11.5		 1y93A-4l63A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4l63 ECXA
(Escherichia
coli) 		4 / 4 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.14A 2hu6A-4l63A:
11.7		 2hu6A-4l63A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 4l63 ECXA
(Escherichia
coli) 		6 / 9 LEU A 122
THR A 176
HIS A 179
GLU A 180
HIS A 183
HIS A 189
 None
None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.37A 2jihA-4l63A:
6.7		 2jihA-4l63A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 4l63 ECXA
(Escherichia
coli) 		6 / 8 LEU A 122
THR A 176
HIS A 179
GLU A 180
HIS A 183
HIS A 189
 None
None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.52A 2jihB-4l63A:
6.8		 2jihB-4l63A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4l63 ECXA
(Escherichia
coli) 		4 / 6 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.14A 2ow9A-4l63A:
11.4		 2ow9A-4l63A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 4l63 ECXA
(Escherichia
coli) 		4 / 4 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.15A 2ow9B-4l63A:
11.5		 2ow9B-4l63A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 4l63 ECXA
(Escherichia
coli) 		4 / 4 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.15A 2ozrC-4l63A:
11.6		 2ozrC-4l63A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 4l63 ECXA
(Escherichia
coli) 		4 / 4 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.23A 2ozrD-4l63A:
11.6		 2ozrD-4l63A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 4l63 ECXA
(Escherichia
coli) 		4 / 4 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.30A 2ozrE-4l63A:
11.1		 2ozrE-4l63A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 4l63 ECXA
(Escherichia
coli) 		3 / 3 HIS A 179
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.20A 2ozrF-4l63A:
11.5		 2ozrF-4l63A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4l63 ECXA
(Escherichia
coli) 		4 / 8 PHE A 112
ILE A 177
GLY A 182
ILE A 217
 None
 0.98A 2qwxA-4l63A:
2.2
2qwxB-4l63A:
undetectable		 2qwxA-4l63A:
21.91
2qwxB-4l63A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4l63 ECXA
(Escherichia
coli) 		4 / 8 ASN A  60
ILE A  77
ASP A  81
ARG A  84
 None
 1.03A 2v57A-4l63A:
1.5		 2v57A-4l63A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4l63 ECXA
(Escherichia
coli) 		4 / 8 ASN A  60
ILE A  77
ASP A  81
ARG A  84
 None
 1.03A 2v57C-4l63A:
1.4		 2v57C-4l63A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4l63 ECXA
(Escherichia
coli) 		5 / 12 PHE A 142
ILE A 137
THR A 125
LEU A 219
ILE A 217
 None
 1.27A 3em0B-4l63A:
undetectable		 3em0B-4l63A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4l63 ECXA
(Escherichia
coli) 		6 / 9 LEU A 122
THR A 176
HIS A 179
GLU A 180
HIS A 183
HIS A 189
 None
None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.34A 3hy7A-4l63A:
7.1		 3hy7A-4l63A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4l63 ECXA
(Escherichia
coli) 		5 / 9 HIS A 189
GLU A 192
HIS A 183
ILE A 217
LEU A 219
 ZN  A 301 (-3.3A)
None
ZN  A 301 (-3.4A)
None
None
 1.20A 3hy7B-4l63A:
7.0		 3hy7B-4l63A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4l63 ECXA
(Escherichia
coli) 		6 / 9 LEU A 122
THR A 176
HIS A 179
GLU A 180
HIS A 183
HIS A 189
 None
None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.41A 3hy7B-4l63A:
7.0		 3hy7B-4l63A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4l63 ECXA
(Escherichia
coli) 		4 / 5 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.13A 3kecA-4l63A:
11.5		 3kecA-4l63A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4l63 ECXA
(Escherichia
coli) 		3 / 3 HIS A 179
GLU A 180
HIS A 183
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
 0.10A 3kecB-4l63A:
11.3		 3kecB-4l63A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4l63 ECXA
(Escherichia
coli) 		4 / 5 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.12A 3likA-4l63A:
11.8		 3likA-4l63A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4l63 ECXA
(Escherichia
coli) 		4 / 4 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.12A 3lilA-4l63A:
11.9		 3lilA-4l63A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4l63 ECXA
(Escherichia
coli) 		4 / 5 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.16A 3ljgA-4l63A:
12.0		 3ljgA-4l63A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4l63 ECXA
(Escherichia
coli) 		4 / 5 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.15A 3lkaA-4l63A:
11.6		 3lkaA-4l63A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 4l63 ECXA
(Escherichia
coli) 		5 / 10 ASP A 128
ILE A  47
GLY A  49
VAL A  51
ILE A 184
 None
 1.01A 3oxvB-4l63A:
undetectable		 3oxvB-4l63A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4l63 ECXA
ECXB
(Escherichia
coli;
Escherichia
coli) 		4 / 4 LEU A 276
GLY A 275
GLY A 273
THR B  78
 None
 0.93A 3si7A-4l63A:
undetectable		 3si7A-4l63A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 4l63 ECXB
(Escherichia
coli) 		4 / 5 PHE B  42
ALA B  75
THR B  71
LEU B  85
 None
 1.10A 3t3zC-4l63B:
undetectable		 3t3zC-4l63B:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 4l63 ECXA
(Escherichia
coli) 		5 / 7 TYR A  54
VAL A 110
PHE A 112
VAL A  83
ILE A  95
 None
 1.34A 3zjqB-4l63A:
undetectable		 3zjqB-4l63A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4l63 ECXA
(Escherichia
coli) 		4 / 6 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.19A 4a7bA-4l63A:
11.3		 4a7bA-4l63A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4l63 ECXA
(Escherichia
coli) 		4 / 7 THR A 114
LEU A  75
LYS A  72
ASN A 143
 None
 1.09A 4ib4A-4l63A:
undetectable		 4ib4A-4l63A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4l63 ECXA
(Escherichia
coli) 		4 / 8 PHE A 112
ILE A 177
GLY A 182
ILE A 217
 None
 0.97A 4qogA-4l63A:
undetectable
4qogB-4l63A:
undetectable		 4qogA-4l63A:
21.91
4qogB-4l63A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4l63 ECXB
(Escherichia
coli) 		4 / 6 ASN B  44
TYR B  18
LEU B  20
PHE B  48
 None
 1.25A 4twdB-4l63B:
undetectable
4twdC-4l63B:
undetectable		 4twdB-4l63B:
15.81
4twdC-4l63B:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4l63 ECXB
(Escherichia
coli) 		4 / 7 ALA B  46
ILE B  40
LEU B  85
PHE B  48
 None
 1.13A 4uymB-4l63B:
undetectable		 4uymB-4l63B:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4l63 ECXA
(Escherichia
coli) 		4 / 8 SER A 216
SER A 246
ALA A 206
SER A 270
 None
 0.88A 5l5fY-4l63A:
undetectable
5l5fZ-4l63A:
undetectable		 5l5fY-4l63A:
20.93
5l5fZ-4l63A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 4l63 ECXA
(Escherichia
coli) 		5 / 10 TYR A  34
TYR A  42
ILE A  47
ILE A  44
ILE A 184
 None
 1.48A 5mzrA-4l63A:
undetectable		 5mzrA-4l63A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4l63 ECXA
(Escherichia
coli) 		4 / 4 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.15A 5n5jA-4l63A:
11.7		 5n5jA-4l63A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4l63 ECXA
(Escherichia
coli) 		4 / 5 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.15A 5n5kA-4l63A:
11.5		 5n5kA-4l63A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4l63 ECXA
(Escherichia
coli) 		4 / 8 ILE A 126
THR A 125
THR A 115
SER A 121
 None
 0.95A 6c06C-4l63A:
undetectable		 6c06C-4l63A:
undetectable