SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l69'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		6 / 12 LEU A 175
VAL A 198
GLY A 199
GLY A 203
LEU A 222
ALA A 232
 None
 0.61A 2egvA-4l69A:
23.3		 2egvA-4l69A:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 175
GLY A 199
GLY A 203
LEU A 222
ALA A 232
 None
 0.50A 2egvB-4l69A:
23.5		 2egvB-4l69A:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 175
VAL A 198
GLY A 199
GLY A 203
LEU A 222
 None
 0.55A 2egvB-4l69A:
23.5		 2egvB-4l69A:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 238
ALA A 239
VAL A 184
VAL A 220
ILE A 183
 None
 1.07A 2f8gA-4l69A:
undetectable		 2f8gA-4l69A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  11
PRO A  12
ARG A  68
 None
 0.61A 2qd4B-4l69A:
2.6		 2qd4B-4l69A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 175
VAL A 198
GLY A 199
LEU A 222
ALA A 232
 None
 0.59A 2v3kA-4l69A:
8.1		 2v3kA-4l69A:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 198
GLY A 199
GLY A 203
LEU A 222
ALA A 232
 None
 0.76A 2z0yA-4l69A:
19.3		 2z0yA-4l69A:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 198
GLY A 199
GLY A 203
LEU A 222
ALA A 232
 None
 0.76A 2z0yB-4l69A:
18.4		 2z0yB-4l69A:
34.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 240
ALA A 239
ALA A 232
ILE A 186
THR A 244
 None
 1.14A 3czhA-4l69A:
undetectable		 3czhA-4l69A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 238
ALA A 239
VAL A 184
VAL A 220
ILE A 183
 None
 1.05A 3d1zA-4l69A:
undetectable		 3d1zA-4l69A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 238
ALA A 239
VAL A 184
VAL A 220
ILE A 183
 None
 1.06A 3d20A-4l69A:
undetectable		 3d20A-4l69A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 240
ALA A 239
ALA A 232
ILE A 186
THR A 244
 None
 1.12A 3dl9B-4l69A:
undetectable		 3dl9B-4l69A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 243
THR A 244
GLY A 192
ALA A 170
 None
 0.76A 3jusA-4l69A:
undetectable		 3jusA-4l69A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 243
THR A 244
GLY A 192
ALA A 170
 None
 0.76A 3jusA-4l69A:
undetectable		 3jusA-4l69A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 238
ALA A 239
VAL A 184
VAL A 220
ILE A 183
 None
 1.03A 3nu6B-4l69A:
undetectable		 3nu6B-4l69A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 103
VAL A 240
GLY A 238
VAL A 198
VAL A  81
 None
 1.10A 4j5jB-4l69A:
undetectable		 4j5jB-4l69A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 236
LEU A 237
LEU A 196
ILE A 204
GLY A 199
 None
 1.00A 4xi3B-4l69A:
undetectable		 4xi3B-4l69A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 203
LEU A 222
VAL A 226
THR A 229
ALA A 232
 None
 0.66A 5o96A-4l69A:
22.4
5o96B-4l69A:
16.4		 5o96A-4l69A:
29.77
5o96B-4l69A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 175
GLY A 199
GLY A 203
LEU A 222
ALA A 232
 None
 0.57A 5o96A-4l69A:
22.4
5o96B-4l69A:
22.7		 5o96A-4l69A:
29.77
5o96B-4l69A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		6 / 10 LEU A 175
HIS A 176
GLY A 199
GLY A 203
VAL A 226
ALA A 232
 None
 0.63A 5o96C-4l69A:
22.1
5o96D-4l69A:
22.4		 5o96C-4l69A:
29.77
5o96D-4l69A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 175
GLY A 199
GLY A 203
VAL A 226
ALA A 232
 None
 0.67A 5o96E-4l69A:
14.9
5o96F-4l69A:
27.0		 5o96E-4l69A:
29.77
5o96F-4l69A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		6 / 11 GLY A 199
GLU A 201
GLY A 203
ARG A 228
THR A 229
ALA A 232
 None
 1.16A 5o96G-4l69A:
27.3		 5o96G-4l69A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		8 / 11 LEU A 175
GLY A 199
GLU A 201
GLY A 203
LEU A 222
VAL A 226
THR A 229
ALA A 232
 None
 0.72A 5o96G-4l69A:
27.3		 5o96G-4l69A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		7 / 10 LEU A 175
GLY A 199
GLY A 203
LEU A 222
VAL A 226
THR A 229
ALA A 232
 None
 0.74A 5o96G-4l69A:
27.3
5o96H-4l69A:
22.8		 5o96G-4l69A:
29.77
5o96H-4l69A:
29.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		6 / 10 VAL A 198
GLY A 199
GLY A 203
LEU A 222
THR A 229
ALA A 232
 None
 0.66A 5vm8B-4l69A:
28.0		 5vm8B-4l69A:
30.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 212
PHE A 106
LEU A 107
LEU A  85
ALA A  84
 None
 1.21A 5y7pG-4l69A:
undetectable		 5y7pG-4l69A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 237
ALA A  98
PRO A  78
SER A 193
VAL A  82
 None
 1.46A 6b89B-4l69A:
undetectable		 6b89B-4l69A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  44
ARG A  48
VAL A 134
ARG A 246
 None
 1.14A 6fbvD-4l69A:
undetectable		 6fbvD-4l69A:
13.38