SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 8 GLU A 410
ARG A 413
ARG A 414
LEU A 166
 None
 0.72A 1cmaA-4l6rA:
undetectable
1cmaB-4l6rA:
undetectable		 1cmaA-4l6rA:
13.35
1cmaB-4l6rA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 6 TRP A1007
ASN A1006
LEU A1003
PHE A1065
 None
 1.42A 1ru9H-4l6rA:
undetectable
1ru9L-4l6rA:
undetectable		 1ru9H-4l6rA:
19.86
1ru9L-4l6rA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 5 LEU A1010
TRP A1007
ASN A1006
LEU A1003
 None
 1.48A 1ruaH-4l6rA:
undetectable
1ruaL-4l6rA:
undetectable		 1ruaH-4l6rA:
19.86
1ruaL-4l6rA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 6 TRP A1007
ASN A1006
LEU A1003
PHE A1065
 None
 1.45A 1rukH-4l6rA:
undetectable
1rukL-4l6rA:
undetectable		 1rukH-4l6rA:
19.86
1rukL-4l6rA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 4 PRO A1046
LEU A1106
ILE A1102
ARG A1098
 None
 1.45A 3w1wA-4l6rA:
undetectable		 3w1wA-4l6rA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ARG A 173
GLU A 406
ASN A 174
 None
 0.87A 4imaD-4l6rA:
undetectable		 4imaD-4l6rA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ARG A 173
GLU A 406
ASN A 174
 None
 0.88A 4ip7D-4l6rA:
undetectable		 4ip7D-4l6rA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ALA A 237
TYR A 239
GLY A 393
PHE A 184
GLY A 234
 None
 1.38A 4mmfA-4l6rA:
1.3		 4mmfA-4l6rA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 5 ASN A 174
LEU A 163
SER A 167
LEU A 411
 None
 1.30A 4n09C-4l6rA:
undetectable		 4n09C-4l6rA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 4 ASN A 174
LEU A 163
SER A 167
LEU A 411
 None
 1.24A 5kb5A-4l6rA:
undetectable		 5kb5A-4l6rA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA
(Escherichia
coli;
Homo
sapiens) 		3 / 3 PHE A 303
ARG A 308
GLN A 232
 None
 0.98A 6g1pB-4l6rA:
undetectable		 6g1pB-4l6rA:
22.47