SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 LEU A  44
LEU A 181
LEU A 167
GLY A 135
 None
 1.01A 1a4lC-4l6uA:
undetectable		 1a4lC-4l6uA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 8 VAL A 292
ALA A 322
TRP A 216
PHE A 316
 None
 1.13A 1dmiA-4l6uA:
undetectable
1dmiB-4l6uA:
undetectable		 1dmiA-4l6uA:
21.27
1dmiB-4l6uA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 117
ALA A  30
MET A  37
LEU A 133
THR A 119
 None
 1.46A 1ya3B-4l6uA:
undetectable		 1ya3B-4l6uA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 117
ALA A  30
MET A  37
LEU A 133
THR A 119
 None
 1.45A 2oaxC-4l6uA:
undetectable		 2oaxC-4l6uA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 VAL A  75
VAL A 125
ALA A 129
SER A 132
LEU A 133
 None
 0.92A 3hs6A-4l6uA:
undetectable		 3hs6A-4l6uA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 8 SER A  45
PHE A  64
SER A 132
LEU A 126
 None
 1.05A 3m0wE-4l6uA:
undetectable
3m0wF-4l6uA:
undetectable
3m0wG-4l6uA:
undetectable
3m0wH-4l6uA:
undetectable		 3m0wE-4l6uA:
14.72
3m0wF-4l6uA:
14.72
3m0wG-4l6uA:
14.72
3m0wH-4l6uA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 117
ALA A  30
MET A  37
LEU A 133
THR A 119
 None
 1.38A 3vhuA-4l6uA:
undetectable		 3vhuA-4l6uA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 LEU A 116
LEU A 133
LEU A 158
SER A 157
 None
 0.98A 3vhuA-4l6uA:
undetectable		 3vhuA-4l6uA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 8 ARG A 106
GLU A  84
GLU A  27
ARG A  29
 None
 1.23A 4bqfB-4l6uA:
undetectable		 4bqfB-4l6uA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 PHE A 297
ALA A  43
LEU A 136
SER A  47
GLY A 141
 None
 0.98A 4dm8B-4l6uA:
undetectable		 4dm8B-4l6uA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 SER A 295
LYS A 280
ARG A 293
LEU A 213
 None
 1.27A 4ifxA-4l6uA:
0.5		 4ifxA-4l6uA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 SER A 295
LYS A 280
ARG A 293
LEU A 213
 None
 1.28A 4ig1A-4l6uA:
undetectable		 4ig1A-4l6uA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 188
ILE A 155
LEU A  10
GLY A 135
ILE A 134
 None
 1.20A 4o1eA-4l6uA:
undetectable		 4o1eA-4l6uA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 8 LEU A 167
MET A  37
LEU A  10
ILE A 283
 None
 0.91A 4ok1A-4l6uA:
undetectable		 4ok1A-4l6uA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 10 CYH A 130
LEU A 158
LEU A 164
LEU A 181
LEU A 167
 None
 1.24A 4p65A-4l6uA:
undetectable
4p65B-4l6uA:
undetectable
4p65F-4l6uA:
undetectable
4p65H-4l6uA:
undetectable		 4p65A-4l6uA:
8.94
4p65B-4l6uA:
7.14
4p65F-4l6uA:
7.14
4p65H-4l6uA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 SER A 295
LYS A 280
ARG A 293
LEU A 213
 None
 1.30A 4xdtA-4l6uA:
undetectable		 4xdtA-4l6uA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 4 LEU A 153
ILE A  13
GLY A 141
ILE A 283
 None
 0.62A 5dzk3-4l6uA:
undetectable
5dzkm-4l6uA:
undetectable		 5dzk3-4l6uA:
0.83
5dzkm-4l6uA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 ILE A  13
GLY A 141
ILE A 283
LEU A 153
 None
 0.65A 5dzkB-4l6uA:
undetectable
5dzkI-4l6uA:
undetectable
5dzkW-4l6uA:
undetectable		 5dzkB-4l6uA:
19.88
5dzkI-4l6uA:
19.03
5dzkW-4l6uA:
0.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 ILE A  13
GLY A 141
ILE A 283
LEU A 153
 None
 0.62A 5dzki-4l6uA:
undetectable
5dzkj-4l6uA:
undetectable
5dzkx-4l6uA:
undetectable		 5dzki-4l6uA:
19.03
5dzkj-4l6uA:
19.03
5dzkx-4l6uA:
0.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 4 ILE A  13
GLY A 141
ILE A 283
LEU A 153
 None
 0.76A 5dzkl-4l6uA:
undetectable
5dzkz-4l6uA:
undetectable		 5dzkl-4l6uA:
19.03
5dzkz-4l6uA:
0.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 GLU A 124
VAL A 125
ASP A 122
LEU A 158
ALA A 129
 None
 1.29A 5syeB-4l6uA:
undetectable		 5syeB-4l6uA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 PHE A 114
GLY A 141
GLY A 151
ALA A 150
LEU A  36
 None
 1.13A 6b3aA-4l6uA:
undetectable		 6b3aA-4l6uA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 PHE A 114
GLY A 141
GLY A 151
ALA A 150
LEU A  36
 None
 1.13A 6b3bA-4l6uA:
undetectable		 6b3bA-4l6uA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 9 VAL A 292
HIS A 291
GLY A 217
ILE A 313
ARG A 293
 None
 1.22A 6c2mC-4l6uA:
undetectable		 6c2mC-4l6uA:
13.07