SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l7m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		4 / 7 LEU A  41
THR A  49
LEU A  51
LEU A  57
 None
 0.88A 1gtiB-4l7mA:
undetectable		 1gtiB-4l7mA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		5 / 10 ALA A 116
LEU A  77
SER A 140
LEU A 139
VAL A 138
 None
 1.07A 2bxgB-4l7mA:
2.1		 2bxgB-4l7mA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		5 / 11 LEU A  41
LEU A  57
ALA A  53
ALA A  83
VAL A  79
 None
 1.20A 3e22B-4l7mA:
2.6		 3e22B-4l7mA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		5 / 11 LEU A  41
LEU A  57
ALA A  53
ALA A  83
VAL A  79
 None
 1.18A 3e22D-4l7mA:
undetectable		 3e22D-4l7mA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		5 / 12 LEU A 120
LEU A 142
VAL A 103
ILE A  81
LEU A  77
 None
 1.02A 3fl9B-4l7mA:
undetectable		 3fl9B-4l7mA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		5 / 10 LEU A 120
LEU A 142
VAL A 103
ILE A  81
LEU A  77
 None
 1.16A 3fl9E-4l7mA:
undetectable		 3fl9E-4l7mA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		4 / 4 LYS A 226
SER A 261
LEU A 230
SER A 233
 None
 1.35A 3ik6H-4l7mA:
0.0		 3ik6H-4l7mA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		4 / 5 LYS A 226
SER A 261
LEU A 230
SER A 233
 None
 1.32A 3iluH-4l7mA:
undetectable		 3iluH-4l7mA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		4 / 6 LEU A  57
LEU A  61
LEU A  77
LEU A  73
 None
 0.89A 3q1eA-4l7mA:
undetectable
3q1eC-4l7mA:
undetectable		 3q1eA-4l7mA:
17.56
3q1eC-4l7mA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		4 / 6 LEU A  77
LEU A  73
LEU A  57
LEU A  61
 None
 0.86A 3q1eA-4l7mA:
undetectable
3q1eC-4l7mA:
undetectable		 3q1eA-4l7mA:
17.56
3q1eC-4l7mA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		5 / 12 LEU A 102
ALA A  98
LEU A  57
ALA A  42
ALA A  83
 None
 1.17A 3ut5D-4l7mA:
2.5		 3ut5D-4l7mA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		4 / 8 PHE A  80
LEU A  39
ILE A  38
ILE A  60
 None
 0.80A 4em2A-4l7mA:
undetectable		 4em2A-4l7mA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		5 / 9 ALA A 117
ALA A 116
SER A 140
LEU A 139
VAL A 138
 None
 1.08A 4or0A-4l7mA:
2.6		 4or0A-4l7mA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		3 / 3 ASP A 147
ASN A 176
PHE A 171
 None
 0.73A 5dsgB-4l7mA:
undetectable		 5dsgB-4l7mA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		4 / 6 PHE A 113
SER A 148
MET A 177
LEU A 114
 None
 1.34A 5dzke-4l7mA:
undetectable
5dzks-4l7mA:
undetectable		 5dzke-4l7mA:
21.50
5dzks-4l7mA:
0.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		5 / 12 LEU A 114
ALA A 117
LEU A 142
ILE A 155
LEU A 208
 None
 1.15A 5ljcA-4l7mA:
undetectable		 5ljcA-4l7mA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		4 / 7 GLY A 185
HIS A 186
ASP A 147
ASP A 183
 None
 0.87A 5nnwD-4l7mA:
undetectable		 5nnwD-4l7mA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermococcus
onnurineus) 		5 / 11 GLY A 185
LYS A 215
SER A 218
SER A 181
ASN A 179
 None
 1.24A 5x6yA-4l7mA:
undetectable		 5x6yA-4l7mA:
16.67