SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l7v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
11 / 12 GLY A  83
GLY A  85
GLU A 104
ILE A 106
LEU A 109
ASP A 131
GLY A 132
THR A 148
ALA A 149
VAL A 200
LEU A 202
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-2.7A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.0A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.1A)
None
SAH  A 301 (-4.3A)
0.40A 1jg2A-4l7vA:
27.8
1jg2A-4l7vA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
5 / 12 LEU A 159
GLY A 132
ALA A 151
VAL A 172
LEU A 202
None
SAH  A 301 (-3.4A)
None
None
SAH  A 301 (-4.3A)
0.99A 1jg2A-4l7vA:
27.8
1jg2A-4l7vA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
10 / 11 GLY A  83
GLY A  85
GLU A 104
ARG A 105
ILE A 106
LEU A 109
ASP A 131
GLY A 132
THR A 148
LEU A 202
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-2.7A)
ACT  A 303 ( 2.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.0A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
0.33A 1jg3A-4l7vA:
27.7
1jg3A-4l7vA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
10 / 11 GLY A  83
GLY A  85
GLU A 104
ARG A 105
ILE A 106
LEU A 109
ASP A 131
GLY A 132
THR A 148
LEU A 202
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-2.7A)
ACT  A 303 ( 2.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.0A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
0.32A 1jg3B-4l7vA:
27.7
1jg3B-4l7vA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
6 / 12 GLY A  85
GLY A 132
THR A 148
ALA A 149
VAL A 200
LEU A 202
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.1A)
None
SAH  A 301 (-4.3A)
0.38A 1jg4A-4l7vA:
28.0
1jg4A-4l7vA:
36.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
8 / 8 GLU A  81
GLY A  83
SER A  86
GLU A 104
ARG A 105
ILE A 106
LEU A 109
ASP A 131
SAH  A 301 ( 4.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-2.6A)
SAH  A 301 (-2.7A)
ACT  A 303 ( 2.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.0A)
0.43A 1jg4A-4l7vA:
28.0
1jg4A-4l7vA:
36.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
5 / 12 GLU A  81
GLY A  83
GLY A  85
LEU A 109
ASP A 131
SAH  A 301 ( 4.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.0A)
0.49A 1qaoA-4l7vA:
9.5
1qaoA-4l7vA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
4 / 7 LEU A 146
VAL A 147
THR A 148
VAL A 197
None
None
SAH  A 301 (-3.4A)
None
0.97A 2qblA-4l7vA:
undetectable
2qblA-4l7vA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
4 / 5 LEU A  24
GLN A  16
THR A  14
THR A  68
None
1.34A 2zj0B-4l7vA:
3.5
2zj0B-4l7vA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
4 / 4 LEU A  24
GLN A  16
THR A  14
THR A  68
None
1.45A 2zj0D-4l7vA:
5.6
2zj0D-4l7vA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
4 / 5 VAL A  79
VAL A 100
THR A 148
THR A  77
None
None
SAH  A 301 (-3.4A)
None
1.18A 3bjwA-4l7vA:
undetectable
3bjwA-4l7vA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
4 / 5 VAL A  79
VAL A 100
THR A 148
THR A  77
None
None
SAH  A 301 (-3.4A)
None
1.12A 3bjwG-4l7vA:
undetectable
3bjwG-4l7vA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
4 / 5 VAL A  79
VAL A 100
THR A 148
THR A  77
None
None
SAH  A 301 (-3.4A)
None
1.14A 3bjwD-4l7vA:
undetectable
3bjwD-4l7vA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
5 / 11 GLU A  81
GLY A  83
GLY A  85
GLU A 104
ASP A 131
SAH  A 301 ( 4.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-2.7A)
SAH  A 301 (-4.0A)
0.58A 3dxyA-4l7vA:
8.3
3dxyA-4l7vA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
5 / 11 GLY A  83
GLY A  85
GLU A 104
LEU A 109
ASP A 131
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-2.7A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.0A)
0.73A 3grvA-4l7vA:
12.2
3grvA-4l7vA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
6 / 12 GLU A  81
GLY A  83
GLY A  85
GLU A 104
LEU A 109
ASP A 131
SAH  A 301 ( 4.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-2.7A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.0A)
0.80A 3gryA-4l7vA:
12.0
3gryA-4l7vA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
4 / 4 LEU A 158
ALA A 151
VAL A 172
PRO A 171
None
1.16A 3gv1B-4l7vA:
undetectable
3gv1B-4l7vA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
5 / 9 LEU A  96
ALA A  26
LEU A  24
THR A  68
LEU A  93
None
1.40A 4ltwA-4l7vA:
undetectable
4ltwA-4l7vA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
3 / 3 ASP A   7
HIS A  28
LYS A   5
None
0.85A 4qzuD-4l7vA:
undetectable
4qzuD-4l7vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
5 / 11 LEU A  30
TYR A  88
ILE A 122
GLU A  81
LEU A  96
None
None
None
SAH  A 301 ( 4.6A)
None
1.40A 4yvpA-4l7vA:
undetectable
4yvpA-4l7vA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
4 / 5 SER A 157
ARG A 105
GLY A  83
GLU A 104
None
ACT  A 303 ( 2.4A)
SAH  A 301 (-3.3A)
SAH  A 301 (-2.7A)
1.15A 5btiA-4l7vA:
undetectable
5btiB-4l7vA:
undetectable
5btiA-4l7vA:
20.13
5btiB-4l7vA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
5 / 7 GLY A  83
GLY A  85
SER A  86
GLU A 104
ASP A 131
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-2.6A)
SAH  A 301 (-2.7A)
SAH  A 301 (-4.0A)
0.71A 5ergB-4l7vA:
12.5
5ergB-4l7vA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
5 / 12 VAL A  64
GLU A  81
GLY A  83
TYR A  88
ALA A 149
None
SAH  A 301 ( 4.6A)
SAH  A 301 (-3.3A)
None
SAH  A 301 ( 4.1A)
1.16A 5n5dA-4l7vA:
12.0
5n5dA-4l7vA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
4 / 5 VAL A 125
THR A 127
VAL A  64
LEU A  71
None
0.85A 6bqgA-4l7vA:
undetectable
6bqgA-4l7vA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio
cholerae)
5 / 12 GLU A  81
ILE A  82
GLY A  83
GLY A  85
LEU A 109
SAH  A 301 ( 4.6A)
SAH  A 301 ( 4.7A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.6A)
0.55A 6iftA-4l7vA:
10.2
6iftA-4l7vA:
21.07