SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l7w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4l7w HD DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 11 GLU A 146
ARG A  52
LEU A 149
GLU A 153
ALA A 151
 None
 1.19A 1mjlA-4l7wA:
undetectable
1mjlB-4l7wA:
undetectable		 1mjlA-4l7wA:
16.99
1mjlB-4l7wA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4l7w HD DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLU A 146
ARG A  52
LEU A 149
GLU A 153
GLY A  34
 None
 1.16A 1mjlA-4l7wA:
undetectable
1mjlB-4l7wA:
undetectable		 1mjlA-4l7wA:
16.99
1mjlB-4l7wA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 4l7w HD DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A  34
GLU A 146
ARG A  52
GLU A 153
ALA A 151
 None
 0.90A 1mjqC-4l7wA:
undetectable
1mjqD-4l7wA:
undetectable		 1mjqC-4l7wA:
16.99
1mjqD-4l7wA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 4l7w HD DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A  34
GLU A 146
ARG A  52
GLU A 153
ALA A 151
 None
 0.91A 1mjqI-4l7wA:
undetectable
1mjqJ-4l7wA:
undetectable		 1mjqI-4l7wA:
16.99
1mjqJ-4l7wA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)		 4l7w HD DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 11 ARG A  52
LEU A 164
PHE A 167
TYR A 168
LEU A 157
 None
 1.23A 1mxfD-4l7wA:
undetectable		 1mxfD-4l7wA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4l7w HD DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 TYR A 168
ASP A 143
GLU A  81
GLU A  44
 None
None
MG  A 303 ( 2.4A)
None
 1.27A 3dh0A-4l7wA:
undetectable		 3dh0A-4l7wA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4l7w HD DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 117
LEU A 113
LEU A 112
GLN A  19
VAL A  24
 None
 1.32A 3zqtA-4l7wA:
undetectable		 3zqtA-4l7wA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4l7w HD DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 TRP A  35
TYR A 168
THR A 171
GLN A 144
 None
 1.41A 5tzoA-4l7wA:
undetectable		 5tzoA-4l7wA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4l7w HD DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 TRP A  35
TYR A 168
THR A 171
GLN A 144
 None
 1.31A 5tzoB-4l7wA:
undetectable		 5tzoB-4l7wA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4l7w HD DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 TRP A  35
TYR A 168
THR A 171
GLN A 144
 None
 1.41A 5tzoC-4l7wA:
undetectable		 5tzoC-4l7wA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4l7w HD DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 7 ASP A 143
ARG A  32
GLU A  81
ASP A  86
 None
MG  A 302 ( 4.0A)
MG  A 303 ( 2.4A)
MG  A 301 ( 2.8A)
 1.17A 6mn5E-4l7wA:
undetectable		 6mn5E-4l7wA:
14.87