SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l7z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		5 / 11 LEU A  59
VAL A  91
GLY A  57
VAL A  78
VAL A  79
 None
 1.07A 1akdA-4l7zA:
undetectable		 1akdA-4l7zA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		5 / 11 ARG A  92
HIS A  37
ALA A  71
PHE A  75
GLY A  74
 None
 1.38A 1cmaA-4l7zA:
undetectable
1cmaB-4l7zA:
undetectable		 1cmaA-4l7zA:
15.57
1cmaB-4l7zA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		5 / 11 LEU A  59
VAL A  91
GLY A  57
VAL A  78
VAL A  79
 None
 1.06A 1phgA-4l7zA:
undetectable		 1phgA-4l7zA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		5 / 12 GLY A 199
GLY A 198
GLN A 221
ASP A 222
PHE A 218
 None
None
TRS  A 500 (-3.7A)
TRS  A 500 (-4.9A)
None
 1.20A 1wg8A-4l7zA:
undetectable		 1wg8A-4l7zA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		5 / 11 LEU A  59
VAL A  91
GLY A  57
VAL A  78
VAL A  79
 None
 1.03A 2a1nA-4l7zA:
undetectable		 2a1nA-4l7zA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		4 / 8 LEU A  59
VAL A  91
GLY A  57
VAL A  78
 None
 0.79A 2a1oA-4l7zA:
undetectable		 2a1oA-4l7zA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		5 / 10 LEU A  59
VAL A  91
GLY A  57
VAL A  78
VAL A  79
 None
 1.06A 2cp4A-4l7zA:
undetectable		 2cp4A-4l7zA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		4 / 5 PHE A 264
ILE A 281
ASN A 291
PHE A 260
 None
 1.35A 3octA-4l7zA:
undetectable		 3octA-4l7zA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		3 / 3 LYS A 123
GLU A 125
TRP A 128
 None
 0.85A 3v4tH-4l7zA:
undetectable		 3v4tH-4l7zA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		3 / 3 LYS A 297
LEU A 294
ALA A 296
 None
 0.64A 4ikiA-4l7zA:
undetectable		 4ikiA-4l7zA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		5 / 12 ILE A 108
ILE A 130
ASP A 129
ILE A 121
ASN A  58
 None
 1.16A 4o1eA-4l7zA:
12.4		 4o1eA-4l7zA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		5 / 9 LEU A  59
VAL A  91
GLY A  57
VAL A  78
VAL A  79
 None
 1.07A 5cp4A-4l7zA:
undetectable		 5cp4A-4l7zA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		5 / 12 GLN A 220
LEU A 223
GLY A 199
HIS A 200
PHE A 218
 None
 1.30A 5m66D-4l7zA:
undetectable		 5m66D-4l7zA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		5 / 12 PHE A  34
PHE A  33
ALA A  81
ILE A 119
LEU A  89
 None
 1.10A 6aybA-4l7zA:
undetectable		 6aybA-4l7zA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		5 / 12 LEU A 156
LEU A 155
GLY A 177
GLY A 270
PRO A 182
 None
 1.11A 6ce2B-4l7zA:
undetectable		 6ce2B-4l7zA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		4 / 6 TRP A 272
LEU A  96
ASP A  61
GLU A  60
 None
 1.49A 6djzC-4l7zA:
undetectable		 6djzC-4l7zA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		5 / 12 GLN A 220
LEU A 223
GLY A 199
HIS A 200
PHE A 218
 None
 1.33A 6exiA-4l7zA:
undetectable		 6exiA-4l7zA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		5 / 12 GLN A 220
LEU A 223
GLY A 199
HIS A 200
PHE A 218
 None
 1.31A 6exiD-4l7zA:
undetectable		 6exiD-4l7zA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4l7z HPCH/HPAI ALDOLASE
(Chloroflexus
aurantiacus) 		5 / 12 ASN A  94
PRO A 122
ILE A 121
VAL A 124
VAL A 133
 None
 1.39A 6j21A-4l7zA:
undetectable		 6j21A-4l7zA:
22.67