SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l82'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 4l82 RIFEA.00250.A
(Rickettsia
felis) 		5 / 12 ILE A  74
SER A  73
ILE A 117
LEU A  40
VAL A 137
 None
 0.83A 2nnhA-4l82A:
undetectable		 2nnhA-4l82A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4l82 RIFEA.00250.A
(Rickettsia
felis) 		6 / 12 GLY A  34
ILE A  24
ILE A  23
LEU A  32
HIS A  85
ILE A  82
 None
None
None
None
CL  A 202 (-4.4A)
CL  A 202 ( 4.8A)
 1.04A 4azvA-4l82A:
undetectable		 4azvA-4l82A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4l82 RIFEA.00250.A
(Rickettsia
felis) 		5 / 10 TYR A 125
ILE A  24
ILE A  23
LEU A  75
ILE A  50
 None
 1.32A 5vkqA-4l82A:
undetectable
5vkqD-4l82A:
undetectable		 5vkqA-4l82A:
7.03
5vkqD-4l82A:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4l82 RIFEA.00250.A
(Rickettsia
felis) 		5 / 10 ILE A  50
TYR A 125
ILE A  24
ILE A  23
LEU A  75
 None
 1.33A 5vkqA-4l82A:
undetectable
5vkqB-4l82A:
undetectable		 5vkqA-4l82A:
7.03
5vkqB-4l82A:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4l82 RIFEA.00250.A
(Rickettsia
felis) 		5 / 10 ILE A  50
TYR A 125
ILE A  24
ILE A  23
LEU A  75
 None
 1.30A 5vkqC-4l82A:
undetectable
5vkqD-4l82A:
undetectable		 5vkqC-4l82A:
7.03
5vkqD-4l82A:
7.03