SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l87'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 7 SER A 374
SER A 330
TYR A 410
LEU A 290
 None
 1.13A 1ibgL-4l87A:
undetectable		 1ibgL-4l87A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ARG A 317
ASP A 378
ASN A 363
 PO4  A 502 ( 3.8A)
MG  A 503 (-3.9A)
None
 0.96A 1nbhA-4l87A:
undetectable		 1nbhA-4l87A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ARG A 317
ASP A 378
ASN A 363
 PO4  A 502 ( 3.8A)
MG  A 503 (-3.9A)
None
 0.95A 1nbhD-4l87A:
undetectable		 1nbhD-4l87A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 9 LEU A 355
ALA A 206
LEU A 207
ALA A 211
PHE A 351
 None
 1.17A 2vcvD-4l87A:
undetectable		 2vcvD-4l87A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 9 LEU A 355
ALA A 206
LEU A 207
ALA A 211
PHE A 351
 None
 1.20A 2vcvH-4l87A:
2.8		 2vcvH-4l87A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 9 LEU A 355
ALA A 206
LEU A 207
ALA A 211
PHE A 351
 None
 1.21A 2vcvI-4l87A:
2.6		 2vcvI-4l87A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ASN A 397
SER A 396
PHE A 341
ASN A 363
 None
 1.19A 2wekA-4l87A:
undetectable		 2wekA-4l87A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ASN A 397
SER A 396
PHE A 341
ASN A 363
 None
 1.25A 2wekB-4l87A:
undetectable		 2wekB-4l87A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ILE A 276
TYR A 224
MET A 229
ILE A 269
 None
 1.04A 3eteA-4l87A:
undetectable
3eteE-4l87A:
undetectable		 3eteA-4l87A:
21.35
3eteE-4l87A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 5 ILE A 276
TYR A 224
MET A 229
ILE A 269
 None
 1.05A 3eteB-4l87A:
undetectable
3eteC-4l87A:
undetectable		 3eteB-4l87A:
21.35
3eteC-4l87A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 7 MET A 229
ILE A 269
ILE A 276
TYR A 224
 None
 1.05A 3eteD-4l87A:
undetectable
3eteF-4l87A:
undetectable		 3eteD-4l87A:
21.35
3eteF-4l87A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ALA A 439
ILE A 440
ASN A 443
PRO A 453
 None
 0.57A 3fxrA-4l87A:
2.2		 3fxrA-4l87A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 6 THR A 347
ARG A 218
LEU A 215
GLY A 216
ALA A 348
 None
 1.37A 3huoA-4l87A:
undetectable		 3huoA-4l87A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 SER A 241
ALA A 373
GLN A  23
TYR A 401
ILE A 135
 None
 1.45A 4iilA-4l87A:
undetectable		 4iilA-4l87A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 6 TYR A 220
GLU A 350
THR A 346
LEU A 215
 None
 1.31A 4qzuC-4l87A:
undetectable		 4qzuC-4l87A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 6 LEU A 215
LEU A 212
ILE A 324
MET A 430
 None
 0.98A 4ww7A-4l87A:
undetectable		 4ww7A-4l87A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 10 ARG A 302
GLU A 304
PHE A 321
GLU A 391
ARG A 435
 SSA  A 501 (-2.4A)
SSA  A 501 (-3.4A)
SSA  A 501 (-3.5A)
MG  A 503 (-3.3A)
SSA  A 501 (-4.0A)
 0.89A 6bniA-4l87A:
10.3		 6bniA-4l87A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 10 ARG A 302
GLU A 304
PHE A 321
GLU A 391
ARG A 435
 SSA  A 501 (-2.4A)
SSA  A 501 (-3.4A)
SSA  A 501 (-3.5A)
MG  A 503 (-3.3A)
SSA  A 501 (-4.0A)
 0.92A 6bniB-4l87A:
12.0		 6bniB-4l87A:
10.86