SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4l8j PUTATIVE EFFLUX
TRANSPORTER
(Bacteroides
eggerthii) 		4 / 7 VAL A 179
LEU A  59
ALA A  85
LEU A  70
 None
 0.84A 1pthA-4l8jA:
undetectable		 1pthA-4l8jA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4l8j PUTATIVE EFFLUX
TRANSPORTER
(Bacteroides
eggerthii) 		4 / 7 VAL A 179
LEU A  59
ALA A  85
LEU A  70
 None
 0.85A 1pthB-4l8jA:
undetectable		 1pthB-4l8jA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4l8j PUTATIVE EFFLUX
TRANSPORTER
(Bacteroides
eggerthii) 		5 / 12 ALA A 155
LEU A  59
ILE A 178
ARG A  62
LEU A  70
 None
 0.95A 1xdkF-4l8jA:
undetectable		 1xdkF-4l8jA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4l8j PUTATIVE EFFLUX
TRANSPORTER
(Bacteroides
eggerthii) 		6 / 12 PRO A 257
VAL A  51
THR A 218
PHE A 220
ILE A 243
PHE A 212
 None
 1.34A 2v95A-4l8jA:
undetectable		 2v95A-4l8jA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 4l8j PUTATIVE EFFLUX
TRANSPORTER
(Bacteroides
eggerthii) 		3 / 3 VAL A  54
GLU A 226
GLU A 225
 None
 0.73A 5jsdB-4l8jA:
undetectable
5jsdC-4l8jA:
undetectable		 5jsdB-4l8jA:
19.30
5jsdC-4l8jA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4l8j PUTATIVE EFFLUX
TRANSPORTER
(Bacteroides
eggerthii) 		4 / 8 ASN A  69
GLN A  66
ILE A  67
GLY A  65
 None
 0.90A 5nzxA-4l8jA:
undetectable		 5nzxA-4l8jA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4l8j PUTATIVE EFFLUX
TRANSPORTER
(Bacteroides
eggerthii) 		4 / 7 ASN A  69
GLN A  66
ILE A  67
GLY A  65
 None
 0.90A 5nzyA-4l8jA:
undetectable		 5nzyA-4l8jA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 4l8j PUTATIVE EFFLUX
TRANSPORTER
(Bacteroides
eggerthii) 		4 / 8 GLY A  65
ASN A 173
ALA A  60
PHE A  61
 None
 0.89A 5xu8A-4l8jA:
undetectable		 5xu8A-4l8jA:
23.24