SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		4 / 8 ARG A 189
SER A 222
ASN A 154
ASP A 156
 None
 1.07A 1hwiB-4l8kA:
undetectable		 1hwiB-4l8kA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		4 / 8 ARG A 189
SER A 222
ASN A 154
ASP A 156
 None
 1.21A 1hwkA-4l8kA:
undetectable		 1hwkA-4l8kA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		4 / 8 ARG A 189
SER A 222
ASN A 154
ASP A 156
 None
 1.19A 1hwkC-4l8kA:
undetectable		 1hwkC-4l8kA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		4 / 8 ARG A 189
SER A 222
ASN A 154
ASP A 156
 None
 1.17A 1hwkD-4l8kA:
undetectable		 1hwkD-4l8kA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		4 / 7 ASP A  50
ASP A  53
ASP A  52
HIS A 208
 None
 1.42A 1t03A-4l8kA:
undetectable		 1t03A-4l8kA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		5 / 12 GLY A 265
GLY A 266
ASN A 244
PHE A  43
ASP A 245
 None
PO4  A 401 (-3.3A)
None
None
MPD  A 403 (-4.0A)
 1.17A 2c49A-4l8kA:
undetectable		 2c49A-4l8kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		5 / 12 GLY A 177
ASP A 174
GLY A 264
VAL A 233
VAL A 172
 None
 1.00A 2nnkA-4l8kA:
undetectable		 2nnkA-4l8kA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		5 / 12 ASN A 244
GLY A 265
ASP A 245
VAL A 217
PHE A  43
 None
None
MPD  A 403 (-4.0A)
MPD  A 403 (-4.3A)
None
 1.30A 3k13A-4l8kA:
undetectable		 3k13A-4l8kA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		5 / 10 ILE A 300
ILE A 320
ILE A 321
MET A 259
VAL A 247
 None
 1.37A 3ohtA-4l8kA:
1.6
3ohtB-4l8kA:
1.7		 3ohtA-4l8kA:
21.41
3ohtB-4l8kA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		4 / 8 ILE A 308
GLU A 322
ALA A 323
ALA A 324
 None
 0.64A 3r9tA-4l8kA:
7.7		 3r9tA-4l8kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		4 / 7 ILE A 308
GLU A 322
ALA A 323
ALA A 324
 None
 0.66A 3r9tB-4l8kA:
7.7		 3r9tB-4l8kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		5 / 12 GLY A 176
GLY A 178
ASP A 174
SER A 239
GLU A 103
 None
 1.29A 3tkaA-4l8kA:
undetectable		 3tkaA-4l8kA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		5 / 9 ASN A 244
GLY A 265
GLY A 299
SER A 284
GLY A 266
 None
None
None
PO4  A 401 (-2.6A)
PO4  A 401 (-3.3A)
 1.21A 3ztvA-4l8kA:
undetectable		 3ztvA-4l8kA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		5 / 9 GLY A 265
GLY A 299
ARG A 237
GLY A 266
PHE A 298
 None
None
None
PO4  A 401 (-3.3A)
None
 1.42A 4h2fA-4l8kA:
undetectable		 4h2fA-4l8kA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		5 / 10 VAL A 172
TYR A 143
PHE A 246
SER A 145
GLY A 177
 None
 1.23A 4mmdA-4l8kA:
undetectable		 4mmdA-4l8kA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		5 / 12 MET A 180
PHE A 146
VAL A 249
GLY A 265
THR A 263
 MPD  A 403 ( 4.2A)
None
None
None
None
 1.20A 4mubA-4l8kA:
undetectable		 4mubA-4l8kA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		5 / 12 GLY A 265
GLY A 266
ASN A 244
PHE A  43
ASP A 245
 None
PO4  A 401 (-3.3A)
None
None
MPD  A 403 (-4.0A)
 1.26A 4ubeA-4l8kA:
undetectable		 4ubeA-4l8kA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		5 / 12 MET A 180
PHE A 146
VAL A 249
GLY A 265
THR A 263
 MPD  A 403 ( 4.2A)
None
None
None
None
 1.19A 5byjA-4l8kA:
undetectable		 5byjA-4l8kA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4l8k PUTATIVE PEPTIDASE
(Parabacteroides
merdae) 		4 / 5 ASN A 108
TYR A 240
GLY A 265
ASP A 174
 None
MPD  A 402 (-4.0A)
None
None
 1.15A 6gh9A-4l8kA:
undetectable		 6gh9A-4l8kA:
13.01